Tara C. Marcink

A fusion protein’s weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein

Maximilian Crosby, Ariel J. Kuhn, Gillian Zipursky, Tara C. Marcink et autres

ABSTRACT Human parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusion (F) glycoproteins, which together form the fusion/entry …

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BPS2026 – Induction of host membrane curvature by the HPIV3 fusion peptide reveals a mechanical role in pre-fusion membrane destabilization

Melanie A. Brunet, Laura J. S. Lopes, Wenjing Cheng, Tara C. Marcink et autres

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Data from: A fusion protein’s weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein

Maximilian Crosby, Ariel J. Kuhn, Tara C. Marcink, Samuel H. Gellman et autres

Human parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusion (F) glycoproteins, which together form the fusion/entry complex. …

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Enhancing the solubility of SARS-CoV-2 inhibitors to increase future prospects for clinical development

Ariel J. Kuhn, Victor K. Outlaw, Tara C. Marcink, Zhen Yu et autres

ABSTRACT SARS-CoV-2 poses an ongoing threat to human health as variants continue to emerge. Several effective vaccines are available, but a diminishing number of Americans receive the updated vaccines (only 22% received the 2023 update). Public hesitancy towards vaccines and common occurrence …

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How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody

Tara C. Marcink, Gillian Zipursky, Elizabeth B. Sobolik, Kate Golub et autres

Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populations. There are no approved vaccines or therapeutics for HPIV3. Neutralizing …

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Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry

Kyle N. Stearns, George D. Lampe, Rachel Hanan, Tara C. Marcink et autres

ABSTRACT Human parainfluenza virus 3 (HPIV3) infection is driven by the coordinated action of viral surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion protein (F). Receptor-engaged HN activates F to insert into the target cell membrane and drive virion-cell membrane fusion. For F to …

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A neutralizing antibody prevents postfusion transition of measles virus fusion protein

Dawid S. Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky et autres

Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the general population declines and as populations of immunocompromised individuals, who cannot be vaccinated, increase. There are no approved therapeutics for MeV. Neutralizing antibodies targeting viral fusion …

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Host Cell Membrane Capture by the SARS-CoV-2 Spike Protein Fusion Intermediate

Rui Su, Jin Zeng, Tara C. Marcink, Matteo Porotto et autres

Cell entry by SARS-CoV-2 is accomplished by the S2 subunit of the spike S protein on the virion surface by capture of the host cell membrane and fusion with the viral envelope. Capture and fusion require the prefusion S2 to transit to …

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Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

Tara C. Marcink, Gillian Zipursky, Wenjing Cheng, Kyle N. Stearns et autres

Paramyxoviruses-including important pathogens like parainfluenza, measles, and Nipah viruses-use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use cryo-electron tomography to visualize the fusion complex of human parainfluenza virus …

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Paramyxoviruses: Parainfluenza Viruses

Tara C. Marcink, Janet A. Englund, Anne Moscona

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Intermediates in SARS-CoV-2 spike–mediated cell entry

Tara C. Marcink, Tom Kicmal, Emily Armbruster, Zhening Zhang et autres

SARS-CoV-2 cell entry is completed after viral spike (S) protein-mediated membrane fusion between viral and host cell membranes. Stable prefusion and postfusion S structures have been resolved by cryo-electron microscopy and cryo-electron tomography, but the refolding intermediates on the fusion pathway are …

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Cryo-ET tilt series of HPIV3 clinical isolates in the presence of an F neutralizing Fab

Tara C. Marcink, W Cheng, Matteo Porotto, des Georges A et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.