Gillian Zipursky

A fusion protein’s weak link: functional constraints revealed by inhibitory peptide interaction with the parainfluenza fusion protein

Maximilian Crosby, Ariel J. Kuhn, Gillian Zipursky, Tara C. Marcink et autres

ABSTRACT Human parainfluenza viruses (HPIVs) cause significant respiratory illnesses including croup and pneumonia. HPIV infection begins with fusion of viral and host cell membranes, driven by the coordinated actions of the attachment (HN) and fusion (F) glycoproteins, which together form the fusion/entry …

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Structural and mechanistic basis for antibody neutralization of the measles fusion protein

Dawid S. Zyla, Roberta Della Marca, Davide Lacarbonara, Gele Niemeyer et autres

Measles virus (MeV) is a highly contagious viral pathogen and remains a major global health threat. Resurgent infections, driven by insufficient vaccine coverage, waning herd immunity, and the vulnerability of immunocompromised individuals, highlight the urgent need for effective countermeasures. Monoclonal antibodies (mAbs) …

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Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo

Dawid S. Zyla, Gillian Zipursky, Roberta Della Marca, Davide Lacarbonara et autres

Abstract Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity and mortality in populations with low vaccination coverage. Infection typically leads to immune amnesia and, in rare cases, fatal neurological disease. While current live-attenuated vaccines are highly effective, they …

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Post-covid changes in the epidemiology of pediatric shoulder dislocations: A 10-year national database analysis

Matthew S. Miyasaka, Auston R Locke, Niklas H Koehne, Gillian Zipursky et autres

Background: Previous studies have suggested that inactivity during the COVID-19 pandemic led to higher incidences of injury post-pandemic. This study aims to explore 10-year trends in pediatric shoulder dislocations presenting to United States emergency departments (EDs). Methods: The National Electronic Injury Surveillance …

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How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody

Tara C. Marcink, Gillian Zipursky, Elizabeth B. Sobolik, Kate Golub et autres

Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading cause of illness in pediatric, older, and immunocompromised populations. There are no approved vaccines or therapeutics for HPIV3. Neutralizing …

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A neutralizing antibody prevents postfusion transition of measles virus fusion protein

Dawid S. Zyla, Roberta Della Marca, Gele Niemeyer, Gillian Zipursky et autres

Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the general population declines and as populations of immunocompromised individuals, who cannot be vaccinated, increase. There are no approved therapeutics for MeV. Neutralizing antibodies targeting viral fusion …

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Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Aya A. Osman, Nicholas L. Mervosh, Ana Nicolle Strat, Tanner J. Euston et autres

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Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

Tara C. Marcink, Gillian Zipursky, Wenjing Cheng, Kyle N. Stearns et autres

Paramyxoviruses-including important pathogens like parainfluenza, measles, and Nipah viruses-use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use cryo-electron tomography to visualize the fusion complex of human parainfluenza virus …

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Intermediates in SARS-CoV-2 spike–mediated cell entry

Tara C. Marcink, Tom Kicmal, Emily Armbruster, Zhening Zhang et autres

SARS-CoV-2 cell entry is completed after viral spike (S) protein-mediated membrane fusion between viral and host cell membranes. Stable prefusion and postfusion S structures have been resolved by cryo-electron microscopy and cryo-electron tomography, but the refolding intermediates on the fusion pathway are …

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Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Aya A. Osman, Nicholas L. Mervosh, Ana Nicolle Strat, Tanner J. Euston et autres

Abstract Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder with complex pathophysiology including both genetic and environmental factors. Recent evidence demonstrates the gut microbiome and its resultant metabolome can influence brain and behavior and have been implicated in ASD. To investigate …

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The Neurobiology of Borderline Personality Disorder

M. Mercedes Pérez-Rodríguez, Andrea Bulbena‐Cabré, Anahita Bassir Nia, Gillian Zipursky et autres

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A systematic review of left unilateral electroconvulsive therapy

Charles H. Kellner, Kate G. Farber, Xi Chen, Anita Mehrotra et autres

OBJECTIVE: To systematically review the published clinical trials, case series, and case reports on left unilateral (LUL) electrode placement for clinical electroconvulsive therapy (ECT). METHOD: PubMed, Ovid Medline, and the Cochrane Library were searched for articles concerning LUL ECT. Number of patients, …

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