Iain A. S. Drummond

Injury-induced Cxcl11 and neutrophil signaling drive zebrafish kidney regeneration by generating a nephrogenic niche of Fgf and Wnt expression

Olaleye Olajuyin, Heiko Joachim Schenk, William G. B. Sampson, Omodasola Adekeye et autres

Abstract Adult zebrafish regenerate their kidneys after injury by activating quiescent renal stem cells, however the injury signals that activate kidney stem cells are not known. We show here that an innate immune, cytokine response after tubule injury is required and sufficient …

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Reciprocal inhibition of Wnt signaling pathways pattern the interconnection of epithelial tubules in the regenerating zebrafish kidney

Caramai N. Kamei, William G. B. Sampson, Carolin Albertz, Oliver Aries et autres

In the adult zebrafish kidney, nephrogenesis occurs as a regenerative response to injury and provides a model to explore cell signaling pathways required for nephron formation and engraftment. Differentiating kidney tubules interconnect with collecting system epithelia to generate a pathway for fluid …

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Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction

Ilaria R Merutka, K. Ettinger, Melissa Chernick, Ramya T. Kolli et autres

Chronic kidney disease (CKD) affects ∼15% of US adults and over 840 million people worldwide. Environmental contaminants, including pesticides and metals, are increasingly recognized as disease contributors, yet mechanisms and consequences of long-term, low-level mixture exposures remain poorly defined. Our prior work …

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#355 “Bringing the world in”—experiences of an art programme in renal dialysis units

Alice Radley, Iain A. S. Drummond, A. Sergeant, Katie Gallacher et autres

Abstract Background and Aims The transition from end-stage-kidney disease to haemodialysis (HD) forces patients to re-evaluate their personal relationships, role within their community and self-identity. Symptom burden, particularly fatigue, can erode autonomy and isolate patients from their support networks. Many patients feel …

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Age-Dependent Response to AKI in African Turquoise Killifish

Tom Jannek Boewer, Anastasia Paulmann, Matthew D. Cox, Jan Hegermann et autres

Background: Acute kidney injury (AKI) is common, but outcomes and resolution vary markedly by age. Age-dependent regenerative capacity post-AKI is poorly understood, in part due to a lack of suitable models. We propose the short-lived African turquoise killifish (ATK, Nothobranchius furzeri) as …

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Sterile Inflammation Plays a Crucial Role in Adult Zebrafish Kidney Regeneration

Olaleye Olajuyin, Heiko Joachim Schenk, William Sampson, Caramai N. Kamei et autres

Background: Kidney disease affects over 35 million Americans and has become a significant global health challenge. The shortage of organ donors, combined with the rising number of patients waiting for transplants, has intensified the search for alternative therapies. Zebrafish have a remarkable …

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Distinct Role of Ptprq in Maintaining the Glomerular Filtration Barrier Integrity of the Kidneys

Omodasola Adekeye, Blanca de Juan Mora, William Sampson, Caramai N. Kamei et autres

Background: The glomerulus depends on the integrity of podocyte foot processes and slit diaphragms to maintain selective permeability. Disruption of this architecture results in proteinuria, a significant factor in the progression of end-stage kidney disease. Through transcriptomic profiling, we identified ptprq as …

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Multiple Wnt Signaling Pathways Direct Epithelial Tubule Interconnection in Regenerating Zebrafish Kidneys

Iain A. S. Drummond, Caramai N. Kamei, William Sampson, Samuel M. Hughes et autres

Background: Epithelial tubule fusion is fundamental for kidney morphogenesis. Differentiating nephron tubules interconnect with collecting system epithelia to generate a lumenal pathway for fluid excretion. In the adult zebrafish kidney, nephrogenesis and nephron fusion occurs as a regenerative response to injury and …

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Multiple Wnt signaling pathways direct epithelial tubule interconnection in the regenerating zebrafish kidney

Caramai N. Kamei, William Sampson, Carolin Albertz, Oliver Aries et autres

Summary Epithelial tubule fusion is fundamental for kidney morphogenesis. Differentiating nephron tubules interconnect with collecting system epithelia to generate a lumenal pathway for fluid excretion. In the adult zebrafish kidney, nephrogenesis occurs as a regenerative response to injury and provides a model …

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Kidney development, injury and regeneration—Zebrafish

Heiko Joachim Schenk, Iain A. S. Drummond

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Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

Isabel A. López-García, Sunhee Oh, Christopher P. Chaney, Jun Tsunezumi et autres

The formation of functional epithelial tubules is critical for the development and maintenance of many organ systems. While the mechanisms of tubule formation by epithelial cells are well studied, the process of tubule anastomosis-where tubules connect to form a continuous network-remains poorly …

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Retinol Binding Protein 4 Is a Marker for Proteinuria in Humans and Zebrafish

Jan René Haak, Cathiana Kolb, Lena Pollinger, Melanie Grosch et autres

Background: A clinical hallmark of glomerular kidney diseases is proteinuria. In humans, proteinuria is described as the urinary albumin-creatine-ratio. The zebrafish is a widely used model in kidney research. However, up to date proteinuria detection in zebrafish requires transgenic lines, because the …

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