Isabel A. López-García

Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

Isabel A. López-García, Sunhee Oh, Christopher P. Chaney, Jun Tsunezumi et autres

The formation of functional epithelial tubules is critical for the development and maintenance of many organ systems. While the mechanisms of tubule formation by epithelial cells are well studied, the process of tubule anastomosis-where tubules connect to form a continuous network-remains poorly …

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Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

Isabel A. López-García, Sunhee Oh, Christopher P. Chaney, Jun Tsunezumi et autres

SUMMARY The formation of functional epithelial tubules is a central feature of many organ systems. Although the process of tubule formation by epithelial cells is well-studied, the way in which tubules connect with each other (i.e. anastomose) to form functional networks both …

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Life cycle assessment of biofuels

Paris A. Fokaides, Elias A. Christoforou, Isabel A. López-García, Guillermo Garcia‐Garcia

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Kctd13 deletion reduces synaptic transmission via increased RhoA

Christine Ochoa Escamilla, Irina Filonova, Angela K. Walker, Zhong Xuan et autres

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Development of a stretch‐induced neurotrauma model for medium‐throughput screening in vitro: identification of rifampicin as a neuroprotectant

Isabel A. López-García, Domokos Gerő, Bartosz Szczęsny, Petra Szoleczky et autres

BACKGROUND AND PURPOSE: We hypothesized that an in vitro, stretch-based model of neural injury may be useful to identify compounds that decrease the cellular damage in neurotrauma. EXPERIMENTAL APPROACH: , for the screen. The model induced marked alterations in gene expression and …

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Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

Nadiya Druzhyna, Bartosz Szczęsny, Gábor Oláh, Katalin Módis et autres

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Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress

Gábor Oláh, Bartosz Szczęsny, Attila Brunyánszki, Isabel A. López-García et autres

Poly(ADP-ribose) polymerase 1 (PARP-1), the major isoform of the poly (ADP-ribose) polymerase family, is a constitutive nuclear and mitochondrial protein with well-recognized roles in various essential cellular functions such as DNA repair, signal transduction, apoptosis, as well as in a variety of …

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