Eduardo R. Butelman

Examining the impact of maternal oxycodone self-administration during gestation in a translational model

Eduardo R. Butelman, Y T Huang

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The quantitative economon model as a novel computational tool for addiction research.

Jeremy Matthew Haynes, Joel Correa da Rosa, Eduardo R. Butelman, Steven R. Hursh et autres

exchanged, and demand increases on the subsequent encounter due to deprivation. Using a computational implementation of the quantitative economon model, we simulated transaction patterns maintained by four hypothetical situations with high or low levels of deprivation crossed with high or low levels …

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Dynamic Alterations in the Blood Transcriptome Characterize Drug Use Behavior and Co‐Morbidities in Cocaine Use Disorder: A Preliminary Study

Chinwe A. Nwaneshiudu, Kiran Girdhar, Steven P. Kleopoulos, Zhiping Shao et autres

Individuals with cocaine use disorder (CUD) who attempt abstinence experience craving and relapse that can benefit from multimodal treatment monitoring. Longitudinal studies linking behavioral manifestations in CUD to the blood transcriptome are not only limited but also computationally complex. Therefore, we developed …

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The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions

Ahmet O. Ceceli, Yuefeng Huang, Greg Kronberg, Natalie E. McClain et autres

Originally postulated in 2001, the impaired response inhibition and salience attribution (iRISA) model of addiction highlights the prefrontal cortex (especially the orbitofrontal, dorsolateral, anterior cingulate, and inferior frontal regions) as central to drug addiction symptomatology. Accordingly, drug cues assume a heightened salience …

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Psychiatric comorbidities in substance use disorders: Sex-based differences in a national real-world clinic sample

Eduardo R. Butelman, Yuefeng Huang, Rita Z. Goldstein, Nelly Alia‐Klein

Abstract Objective Substance use disorders (SUD) are associated with risk of psychiatric comorbidities, with inconsistent sex differences, across studies. The objective of this study is to determine odds of psychiatric comorbidities based on sex, in persons with either primary opioid, alcohol or …

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Quantitative Economon Model of Transactions for Drugs and Other Commodities

Jeremy Matthew Haynes, Joel Corrêa da Rosa, Eduardo R. Butelman, Steven R. Hursh et autres

Background: An economon is a dyadic economic unit of two participants who exchange mutually reinforcing commodities (e.g., addictive drugs for money). A human economon often consists of a buyer providing money to a supplier, while the supplier reciprocally provides some commodity to …

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Sex and Hormonal Effects on Drug Cue Reactivity and Its Regulation in Human Addiction

Yuefeng Huang, Eduardo R. Butelman, Ahmet O. Ceceli, Greg Kronberg et autres

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Sex disparities in outcome of medication-assisted therapy of opioid use disorder: Nationally representative outpatient clinic data

Eduardo R. Butelman, Yuefeng Huang, A.H. Mcfarlane, Carolann Slattery et autres

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Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction

Yuefeng Huang, Eduardo R. Butelman, Ahmet O. Ceceli, Greg Kronberg et autres

Objective: To study the sex and hormonal effects on cortico-striatal engagement during drug cue-reactivity and its regulation focusing on drug reappraisal. Methods: Forty-nine men (age=41.96±9.71) with heroin use disorder (HUD) and 32 age-matched women (age=38.85±9.84) with HUD (n=16) or cocaine use disorder …

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Sex disparities in outcome of medication-assisted therapy of opioid use disorder: Nationally representative study

Eduardo R. Butelman, Yuefeng Huang, A.H. Mcfarlane, Carolann Slattery et autres

Abstract Question The opioid epidemic causes massive morbidity, and males have substantially greater overdose mortality rates than females. It is unclear whether there are sex-related disparities at different stages in the trajectory of opioid use disorders, in “real world” settings. Goal To …

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Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder

Chinwe A. Nwaneshiudu, Kiran Kumar Girdhar, Steven P. Kleopoulos, John F. Fullard et autres

Background-: Individuals with cocaine use disorder (CUD) who attempt abstinence experience craving and relapse, which poses challenges in treatment. Longitudinal studies linking behavioral manifestations in CUD to the blood transcriptome in living individuals are limited. Therefore, we investigated the connection between drug …

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IN MEMORIAM MARY JEANNE KREEK

Eduardo R. Butelman

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