Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder
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Le résumé fourni par la source
Background-: Individuals with cocaine use disorder (CUD) who attempt abstinence experience craving and relapse, which poses challenges in treatment. Longitudinal studies linking behavioral manifestations in CUD to the blood transcriptome in living individuals are limited. Therefore, we investigated the connection between drug use behaviors during abstinence with blood transcriptomics. Methods-: We conducted a comprehensive longitudinal study involving 12 subjects (9 males, 3 females) with CUD and RNA sequencing on blood collected at a drug-free baseline, and 3, 6 & 9 months thereafter. We categorized subjects into 2 responder groups (high-low) based on scores of drug use variables, and 3 responder groups (low-intermediate-high) on days of abstinence. We investigated differential expression and gene-transcript associations across responder groups at each time point. Lastly, we examined genes that are both co-expressed and showed dynamic expression with time. Results-: Genes with significant transcript associations between high and. intermediate days of abstinence at 9 months were notably enriched for cannabis use disorder, drinks weekly, and coronary artery disease risk genes. Time-specific gene co-expression analysis prioritized transcripts related to immune processes, cell cycle, RNA-protein synthesis, and second messenger signaling for days of abstinence. Conclusion-: We demonstrate that abstinence reflects robust changes in drug use behaviors and the blood transcriptome in CUD. We also highlight the importance of longitudinal studies to capture complex biological processes during abstinence in CUD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dynamic alterations in gene co-expression networks and gene-transcript associations characterize co-morbidities in cocaine use disorder
- Date Crossref
- 11/07/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Allen Institute for Brain Science pays non établi dans la noticeStructure de recherche
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Icahn School of Medicine at Mount Sinai Center for Disease Neurogenomics pays non établi dans la noticeUniversité ou école supérieure
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James J. Peters VA Medical Center Center for Precision Medicine and Translational Therapeutics pays non établi dans la noticeÉtablissement de santé
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Education and Clinical Centers Mental Illness Research pays non établi dans la noticeOrganisme public
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Mental Illness Research Education and Clinical Center (MIRECC) pays non établi dans la noticeÉtablissement de santé
Allen Institute for Brain Science, Center for Disease Neurogenomics — Icahn School of Medicine at Mount Sinai et Center for Precision Medicine and Translational Therapeutics — James J. Peters VA Medical Center, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.