Shangha Pan

Corrigendum to “The PGC1α/NRF1-MPC1 axis suppresses tumor progression and enhances the sensitivity to sorafenib/doxorubicin treatment in hepatocellular carcinoma” [Free Radic. Biol. Med. 163 (2021) 141–152]

Chaoqun Wang, Liqian Dong, Xiaozhuang Li, Yao Li et autres

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1891P Tislelizumab-based first-line therapy in advanced NSCLC: A real-world study

Tien‐Min Gabriel Chu, Ke Huang, Shangha Pan, Hai Lu et autres

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Retraction Note to: KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling

Jihua Han, Fengyue Wang, Yaliang Lan, Jiabei Wang et autres

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Arsenic trioxide preconditioning attenuates hepatic ischemia- reperfusion injury in mice: Role of ERK/AKT and autophagy

Chaoqun Wang, Hongjun Yu, Shounan Lu, Shanjia Ke et autres

BACKGROUND: Arsenic trioxide (ATO) is indicated as a broad-spectrum medicine for a variety of diseases, including cancer and cardiac disease. While the role of ATO in hepatic ischemia/reperfusion injury (HIRI) has not been reported. Thus, the purpose of this study was to …

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P3.03I.11 The ATXN3-USP25-TRMT1 Axis Regulates tRNAm2,2G Modification and Promotes Osimertinib Resistance in Lung Cancer

Tianqing Chu, Jing Li, Ke Huang, Shangha Pan et autres

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1953P The ATXN3-USP25-TRMT1 axis regulates tRNAm2,2G modification and promotes osimertinib resistance in lung cancer

Tianqing Chu, Jing Li, Ke Huang, Shangha Pan et autres

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Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming Xie, Tiemin Pei, Jiabei Wang et autres

The Editors-in-Chief have retracted this article after concerns were raised about the data reported. Specifically: In Figure 3B, the top SMMC7721 panels appear to overlap. The bottom shCon panel of SMMC7721 panel of this figure also appears to overlap with the shZEB1 …

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circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer

Zhongjie Zhao, Wenbo Yang, Rui Kong, Yangyang Zhang et autres

BACKGROUND: Among digestive tract tumours, pancreatic ductal adenocarcinoma (PDAC) shows the highest mortality trend. Moreover, although PDAC metastasis remains a leading cause of cancer-related deaths, the biological mechanism is poorly understood. Recent evidence demonstrates that circular RNAs (circRNAs) play important roles in …

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Nitrogen-Doped Carbon Dots with Oxidation Stress Protective Effects for Reactive Oxygen Species Scavenging on Hepatic Ischemia–Reperfusion Injury

Dong Chen, Chaoqun Wang, Hongjun Yu, Guanxiong Liu et autres

Hepatic ischemia–reperfusion injury (HIRI), which is a common pathophysiological process that occurs in hepatectomy, affects the survival and prognosis of patients. In this study, we synthesized chitosan-derived nitrogen-doped carbon dots (CNDs) with reactive oxygen species (ROS) scavenging capabilities and applied them in …

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Data from Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

Bo Zhai, Fengli Hu, Xian Li Jiang, Jun Xu et autres

Abstract Sorafenib is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), but the acquired resistance to sorafenib results in limited benefits. Activation of Akt is thought to be responsible for mediating the acquired resistance to sorafenib. The present study aims …

Supplementary Figure 4 from Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

Bo Zhai, Fengli Hu, Xian Li Jiang, Jun Xu et autres

PDF file - 327K, Supplementary Fig. S4.Akt inhibition or depletion synergizes with sorafenib to inhibit cell growth by regulating autophagic and apoptotic pathways in sorafenib-resistant HCC cells.

Supplementary Figure 5 from Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

Bo Zhai, Fengli Hu, Xian Jiang, Jun Xu et autres

PDF file - 225K, Supplementary Fig. S5.Interactions of Akt, autophagic and apoptotic pathways in sorafenib-resistant HCC cells.(A) Immunoblots of lysates of HepG2-SR and Huh7-SR cells following incubation with sorafenib (10 μM), GDC0068 (5 μM) or in combination for 48 h.