Kevin W. Huggins

Epigenetic and microbiome responses to greens supplementation in obese older adults: results from a randomized crossover-controlled trial

Laura A. Robinson, Aidan M. Cavanah, Sarah Lennon, Madison L. Mattingly et autres

Aging is influenced by genetic, environmental, and lifestyle factors. Preliminary studies suggest that fruit and vegetable-based dietary supplements may reduce inflammation and oxidative stress, key factors in aging. Greens-based supplements typically contain concentrated extracts of leafy greens, fruits, vegetables, and bioactive phytochemicals, …

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Advances in GLP-1 receptor agonists delivery systems for obesity and diabetes

Mehrnaz Abbasi, Kai Sun, Kevin W. Huggins, Braeden Heath et autres

Obesity and diabetes are chronic metabolic diseases affecting millions worldwide. Current treatments, including lifestyle changes, medications, and surgery, face challenges like poor adherence and side effects. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are recommended innovative medications for these conditions, with studies showing significant …

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Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Dakota Tiede, Daniel L. Plotkin, Mason C. McIntosh, John Max Michel et autres

Introduction We sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of untrained adults (n = 119, 62M/57F, 26.0 …

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Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Dakota Tiede, Daniel L. Plotkin, Mason C. McIntosh, John Max Michel et autres

ABSTRACT We sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of untrained adults (n=119, 62M/57F, 26.0±4.7 kg/m 2 …

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Fecal Microbiota and Associated Metabolites Are Minimally Affected by Ten Weeks of Resistance Training in Younger and Older Adults

Anthony Agyin-Birikorang, Sarah Lennon, Kristen S. Smith, William Van Der Pol et autres

Preclinical evidence suggests that short chain fatty acids (SCFAs) produced by gut microbiota may impact body composition and muscle growth. While aging is implicated in negative alterations to the gut microbiome, exercise may mitigate these changes. Limited human evidence indicates that resistance …

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Neuroprotective Effect of Stearidonic Acid on Amyloid β-Induced Neurotoxicity in Rat Hippocampal Cells

Yueru Li, Wencong Lai, Zheng Chen, Jeganathan Ramesh Babu et autres

Dietary intake of omega-3 fatty acids found in fish has been reported to reduce the risk of Alzheimer's Disease (AD). Stearidonic acid (SDA), a plant-based omega-3 fatty acid, has been targeted as a potential surrogate for fish-based fatty acids. However, its role …

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Exploring the Effects of Six Weeks of Resistance Training on the Fecal Microbiome of Older Adult Males: Secondary Analysis of a Peanut Protein Supplemented Randomized Controlled Trial

Johnathon H. Moore, Kristen S. Smith, Dongquan Chen, Donald A. Lamb et autres

The bacteria inhabiting the gastrointestinal tract contribute to numerous host functions and can be altered by lifestyle factors. We aimed to determine whether a 6-week training intervention altered fecal microbiome diversity and/or function in older males. Fecal samples were collected prior to …

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Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults

Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn et autres

The aim of this study was to investigate the effects of resistance training (RT) on the redox status of skeletal muscle in older adults. Thirteen males aged 64 ± 9 years performed full-body RT 2x/week for 6 weeks. Muscle biopsies were obtained …

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The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals

Donald A. Lamb, Johnathon H. Moore, Morgan A. Smith, Christopher G. Vann et autres

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The Effects of Resistance Training With or Without Peanut Protein Supplementation on Skeletal Muscle and Strength Adaptations in Older Individuals

Donald A. Lamb, Johnathon H. Moore, Morgan A. Smith, Christopher G. Vann et autres

Abstract Several studies suggest resistance training (RT) with protein supplementation has positive effects on strength and muscle mass in older individuals. However, to date, no study has examined the effects of RT with a high-protein, defatted peanut powder (PP) supplement on these …

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Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

Paulo H. C. Mesquita, Donald A. Lamb, Hailey A. Parry, Johnathon H. Moore et autres

We investigated the acute and chronic effects of resistance training (RT) on skeletal muscle markers of mitochondrial content and remodeling in older, untrained adults. Sixteen participants (n = 6 males, n = 10 females; age = 59 ± 4 years) completed 10 …

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Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

Donald A. Lamb, Johnathon H. Moore, Paulo H. C. Mesquita, Morgan A. Smith et autres

, NADH, and global SIRT activity are positively affected by resistance training in middle-aged, untrained individuals. Whether these adaptations facilitated mitochondrial biogenesis remains to be determined.

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