J. Max Michel

Emerging mechanisms associated with disuse-induced skeletal muscle atrophy

J. Max Michel, David C. Hughes, Christopher G. Vann, Michael D. Roberts

ABSTRACT Skeletal muscle atrophy resulting from disuse represents a significant clinical challenge, characterized by reduced myofiber and muscle tissue size, net protein loss, and functional decline. Although several reviews have covered this topic in depth, we aimed to discuss the emerging mechanisms …

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Large increases in resistance training volume do not impair skeletal muscle hypertrophy or anabolic–catabolic molecular signalling in trained individuals

Julio Benvenutti Bueno Camargo, Diego Bittencourt, J. Max Michel, Deivid Gomes Silva et autres

ABSTRACT Skeletal muscle hypertrophy results from the integrated regulation of anabolic and proteolytic processes in response to mechanical loading. Although increases in resistance training (RT) volume are used to increase mechanical stress, it remains uncertain whether large and abrupt volume progressions could …

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Skeletal muscle myosin heavy chain fragmentation following exercise may be linked to post‐exercise inflammation and remodelling

Dakota Tiede, Diego Bittencourt, J. Max Michel, Daniel L. Plotkin et autres

Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHC frag ) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, …

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Limited effects of dietary nitrate supplementation with resistance training on skeletal muscle and vascular outcomes in middle-aged and older adults

Mason C. McIntosh, Breanna J. Mueller, Dakota Tiede, Derick A. Anglin et autres

Results from this study suggest that 12 wk of dietary nitrate supplementation does not significantly alter skeletal muscle hypertrophic, strength, or vascular outcomes in previously untrained middle-aged and older adults who performed resistance training.

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Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Dakota Tiede, Daniel L. Plotkin, Mason C. McIntosh, J. Max Michel et autres

Introduction We sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of untrained adults (n = 119, 62M/57F, 26.0 …

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EFFECTS OF LEG IMMOBILIZATION AND RECOVERY RESISTANCE TRAINING ON SKELETAL MUSCLE IN TRAINED VERSUS UNTRAINED ADULTS

J. Max Michel, Joshua S. Godwin, Daniel L. Plotkin, Mason C. McIntosh et autres

PURPOSE: We sought to examine how resistance training (RT) status in young healthy individuals, either well resistance trained (T, n = 10) or untrained (UT, n = 11), affected molecular markers with leg immobilization followed by recovery RT. METHODS: All participants underwent …

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Is there a volume saturation point for muscle hypertrophy in resistance-trained individuals? A narrative review

Julio Camargo, Diego Bittencourt, Deivid Gomes da Silva, João Guilherme Almeida Bergamasco et autres

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Effects of 12-Week Dietary Nitrate Supplementation with Resistance Training on Skeletal Muscle and Vascular Outcomes and in Older Adults

Mason C. McIntosh, Breanna J. Mueller, Dakota Tiede, Derick Anglin et autres

Increasing dietary nitrate (NO3-) through beetroot juice (BRJ) supplementation elicits acute ergogenic benefits. However, it is unknown whether chronic NO3- supplementation can enhance resistance training (RT) adaptations in middle-aged and older individuals. Therefore, we sought to determine whether 12 weeks of combined …

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Disuse and subsequent recovery resistance training affect skeletal muscle angiogenesis-related markers regardless of prior resistance training experience

Mason C. McIntosh, J. Max Michel, Joshua S. Godwin, Daniel L. Plotkin et autres

138: 450-467, 2025, we sought to examine how limb immobilization and recovery resistance training affect molecular outcomes related to angiogenesis in younger adults with or without a prior training history. Regardless of resistance training history, the molecular responses are largely similar between …

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Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

Dakota Tiede, Daniel L. Plotkin, Mason C. McIntosh, J. Max Michel et autres

ABSTRACT We sought to determine if pre-intervention bone characteristics measured by dual-energy x-ray absorptiometry (DXA) were associated with changes in bone-free lean tissue mass following a period of resistance training in a large cohort of untrained adults (n=119, 62M/57F, 26.0±4.7 kg/m 2 …

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Resistance exercise and mechanical overload upregulate vimentin for skeletal muscle remodeling

Joshua S. Godwin, J. Max Michel, Cleiton Augusto Libardi, Andreas N. Kavazis et autres

Our highly integrative approach suggests that skeletal muscle vimentin seems to function as a mechanosensitive protein that becomes enriched in the extracellular matrix following MOV. Satellite cells may play a role in regulating their expression, and an exaggerated regenerative response occurs when …

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Skeletal muscle atrophy induced by aging and disuse atrophy are strongly associated with the upregulation of the endoplasmic stress protein CHOP in rats

J. Max Michel, Joshua S. Godwin, Nathan R. Kerr, Thomas E. Childs et autres

BACKGROUND: While canonical anabolic and proteolytic pathways have been well examined in the context of skeletal muscle proteostasis, the roles of endoplasmic reticulum stress (ERS) and the induced unfolded protein response (UPR) are underappreciated. Thus, we aimed to determine whether aging and/or …

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