Abhinav Sharma

Integrated Cardiopulmonary Profile as an Additive Signal in Patients Evaluated for Suspected Newly Detected Atrial Fibrillation

Nilima Rajpal Kundnani, Abhinav Sharma, Ciprian Ilie Rosca, Milan Daniel Velimirovici et autres

BACKGROUND: Atrial fibrillation (AF) is associated with atrial remodelling, hemodynamic stress, and complex cardiopulmonary interactions. While natriuretic peptides and echocardiographic abnormalities are established markers of AF-related substrate, the contribution of spirometry changes, as a landmark of pulmonary impairment, remains less clearly defined. …

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Pharmacogenetic Variability and Quality of Life in Adolescent Patients with Schizophrenia: The Impact of Metabolizer Status, Symptom Severity, and Adverse Reactions to Antipsychotic Treatment

Bianca Oana Bucatos, A.M. Romoșan, Liana Dehelean, Radu Stefan Romosan et autres

Background: Schizophrenia in adolescence disrupts neurodevelopment and long-term functioning. While symptom reduction remains a primary treatment goal, quality of life (QoL) represents a critical, patient-centered outcome. Pharmacogenetic variability, particularly in CYP2D6 metabolism of second-generation antipsychotics, may influence tolerability and subjective well-being beyond …

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Sleep Disruption, Psychological Stress, and Preeclampsia in High-Risk Pregnancies During the COVID-19 Era

Nilima Rajpal Kundnani, Abhinav Sharma, Amalia Cornea, Victor Bogdan Buciu et autres

BACKGROUND: Sleep disturbance and psychosocial stress are emerging contributors to hypertensive disorders of pregnancy. The present cohort was recruited during the COVID-19 period, a time marked by substantial changes in prenatal care delivery, social support, and daily routines, which may have influenced …

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Structured Functional Assessment Pathway and Pharmacological Optimization During Cardiovascular Rehabilitation in Chronic Heart Failure: A Retrospective Tertiary Center Study

Miruna Popovici, Abhinav Sharma, Gabriel Florin Răzvan Mogoș, Nilima Rajpal Kundnani et autres

INTRODUCTION: Optimization of guideline-directed medical therapy in chronic heart failure remains challenging in real-world practice, particularly outside settings with routine cardiopulmonary exercise testing. In this context, cardiovascular rehabilitation can improve functional capacity, symptoms, and quality of life, while structured follow-up may also …

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Impact of Early Diagnosis and Immunosuppressive Therapy on Giant Cell Myocarditis Outcomes: A Review

Nilima Rajpal Kundnani, Abhijit Kumar, Abhinav Sharma, Berceanu Vaduva Marcel Mihai et autres

BACKGROUND: Giant cell myocarditis (GCM) is a rare condition with an incompletely understood immune pathogenesis, characterized by inflammatory damage to the myocardium and the presence of multinucleated giant cells on histopathological examination. The frequently fulminant and severe course requires rapid intervention for …

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Genus Klebsiella: Infections Encountered in a General Surgery Department and Antimicrobial Drugs Susceptibility Patterns

Sergiu-Ciprian Matei, Justin Horia Lăpușan, Ana‐Maria Ungureanu, Edida Maghet et autres

Klebsiella species, particularly Klebsiella pneumoniae, are among the most frequently isolated Gram-negative pathogens in surgical departments, associated with a growing trend in multidrug resistance. To identify the types of infections caused by Klebsiella spp. in a general surgery department and to analyze …

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Early-Life β-Lactam Exposure and the Developing Microbiome: Clinical Relevance and Controversies

Nilima Rajpal Kundnani, Abhinav Sharma, Mihaela Codrina Levai, Lucretia Marin-Bancila et autres

Antibiotic-induced dysbiosis has been increasingly implicated in a range of pediatric outcomes, yet the concept remains variably defined and often inconsistently applied. The purpose of this review is to provide an overview and critical evaluation of the available data regarding the effects …

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Cardio-Vasculo-Renal Benefits of SGLT2 Inhibitors in Heart Failure: A Retrospective Study from a Lower-Resource Tertiary Center

Olivia-Maria Bodea, Gabriel Florin Răzvan Mogoș, Nilima Rajpal Kundnani, Abhinav Sharma et autres

Background and Objectives: Heart failure frequently coexists with CKD, compounding prognosis via cardio-renal interplay. Sodium glucose cotransporter 2 (SGLT2) inhibitors have demonstrated cardiovascular and renal benefits in randomized trials, but data remain limited in real-world lower-resource settings. Materials and Methods: We conducted …

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Inflammation and the Need for Biology-Driven Care in Heart Failure

Abhinav Sharma, Virginia Anagnostopoulou, Anique Ducharme

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Impact of Atrial Fibrillation Type on Quality of Life and Clinical Parameters in Patients with Diabetes Mellitus

Paul Gabriel Ciubotaru, Nilima Rajpal Kundnani, Lucretia Marin-Bancila, Daniel Dumitru Nisulescu et autres

Background: Atrial fibrillation (AF) is a prevalent condition with a major influence on patients’ quality of life, especially when blood glucose and heart rate are disrupted and systemic inflammation is present. Objective: This study aimed to compare Kansas City Cardiomyopathy Questionnaire (KCCQ) …

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Venous Manifestations of Gastric Cancer: Bilateral Varicose Veins as a Rare Initial Presentation—A Narrative Review

Anna Laura Maiozzi, Silvia Maccioni, Livia Stanga, Lucretia Marin-Bancila et autres

Background: Varicose veins (VVs) are an overlying manifestation of chronic venous disease, commonly occurring in the lower extremities. While typically linked to primary venous insufficiency, they can occasionally be secondary to systemic disease, e.g., malignancies, by various mechanisms such as tumor compression, …

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Diagnostic Accuracy of AI-Assisted Focused Cardiac Ultrasound (FOCUS) in Primary Care

Mihai Sorin Iacob, Nilima Rajpal Kundnani, Abhinav Sharma, Andreea Valentina Iacob et autres

Background: Focused cardiac ultrasound (FOCUS) can augment the cardiac exam in primary care but is operator-dependent. We evaluated the diagnostic performance of artificial intelligence-assisted FOCUS (AI-FOCUS) performed by family physicians against cardiologist-performed echocardiography. Methods: This research is a prospective cross-sectional study in …

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