Nobuhiko Imahashi

Are matched-related donors always the best choice? A retrospective study exploring the potential of umbilical cord blood

Nobuhiko Imahashi, Takaaki Konuma, Shinichi Kobayashi, Mizuki Watanabe et autres

jp (code pays fourni par la source)

Corrigendum to scoring system for optimal cord blood unit selection for single cord blood transplantation cytotherapy 26 (2024) 286-298

Mizuki Watanabe, Nobuhiko Imahashi, Seitaro Terakura, Sachiko Seo et autres

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Adjustment of low-dose ATG exposure improves outcomes in allogeneic hematopoietic stem cell transplantation: a prospective multicenter study

Shihomi Kuwano, Seitaro Terakura, Kanae Imai, Shiho Hirano et autres

BACKGROUND AIMS: Antithymocyte globulin (ATG) has been used to prevent the incidence of graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Low-dose ATG can suppress GVHD without increasing the risk of infectious complications. However, the relationship between ATG …

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Successful treatment of smoldering multiple myeloma-associated type I cryoglobulinemia with bortezomib and autologous peripheral blood stem cell transplantation

Daiki Hirano, Hiroatsu Iida, Akari Iwakoshi, Akiyo Sunohara et autres

A 52-year-old male developed multiple skin ulcers/purpura in the bilateral lower limbs. A detailed examination led to a diagnosis of type I cryoglobulinemia-related skin lesions, with smoldering multiple myeloma (SMM) as a background disease. After 5 years, dermal symptoms became severe. Although …

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MO12-6 Efficacy and safety of venetoclax and azacytidine for acute myeloid leukemia: a retrospective, single-center study

Yoshiharu Yamaguchi, Daiki Hirano, R. Minami, Satoshi Hirano et autres

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Long-Term Outcome of Eltrombopag With First-Line Immunosuppressive Therapy for Newly Diagnosed Severe Aplastic Anemia

Hirofumi Yokota, Kotaro Miyao, Masashi Sawa, Seitaro Terakura et autres

Background: To investigate whether the addition of eltrombopag (EPAG) to rabbit anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) for newly diagnosed severe aplastic anemia (SAA) improves outcomes and affects the cumulative incidence of clonal evolution (CE), we conducted a multicenter retrospective analysis. Methods: …

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Comparison of fludarabine‐based conditioning regimens in adult cord blood transplantation for myeloid malignancy: A retrospective, registry‐based study

Naoki Kurita, Nobuhiko Imahashi, Shigeru Chiba, Masatsugu Tanaka et autres

Abstract Fludarabine/busulfan and fludarabine/melphalan are viable options as conditioning regimens. However, the optimal fludarabine‐based conditioning in cord blood transplantation (CBT) remains unclear. Therefore, this retrospective, registry‐based study aimed to analyze the impact of five fludarabine‐containing conditioning regimens on 1395 adult patients (median …

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Scoring system for optimal cord blood unit selection for single cord blood transplantation

Mizuki Watanabe, Takaaki Konuma, Nobuhiko Imahashi, Seitaro Terakura et autres

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Effect of Conditioning Regimens and Graft-versus-Host Disease Prophylaxis on the Outcomes of Umbilical Cord Blood Transplantation Performed with Cyclophosphamide/Total Body Irradiation-Based Regimens

Nobuhiko Imahashi, Naoki Kurita, Takaaki Konuma, Satoshi Takahashi et autres

Umbilical cord blood (UCB) is a valuable alternative donor source for allogeneic hematopoietic stem cell transplantation. Various conditioning regimens and graft-versus-host disease (GVHD) prophylaxis regimens aimed at improving the outcomes of umbilical cord blood transplantation (UCBT) have been explored; however, the differences …

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Clonal hematopoiesis of a novel dic(18;20) clone following allogeneic hematopoietic stem cell transplantation

Makoto Ito, Nobuaki Fukushima, Tomoki Fujii, Masaya Numata et autres

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[Diffuse large B-cell lymphoma expressing high-level glyceraldehyde 3-phosphate dehydrogenase complicated with hypoglycemia].

Shiho Hirano, Akari Iwakoshi, Nobuhiko Imahashi, Akihiro Sakai et autres

A 69-year-old male patient was referred to our hospital for further examination of hypoglycemia, splenomegaly, and para-aortic lymphadenopathy. The patient was diagnosed with diffuse large B-cell lymphoma (DLBCL) by para-aortic lymph node biopsy. Hypoglycemia was refractory to glucose supplementation but improved shortly …

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Activated B cells suppress T-cell function through metabolic competition

Nobuhiko Imahashi, Rafet Başar, Yuefan Huang, Fang Wang et autres

BACKGROUND: B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell activating signals. However, the mechanisms by which activated B cells mediate T-cell suppression are not fully understood. METHODS: We investigated …

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