Shihomi Kuwano

BATF3 regulates differentiation of CD8 + T lymphocytes and memory differentiation program

Koji Umemura, Yasuhiro Kojima, Jakrawadee Julamanee, Yusuke Okuno et autres

CD8 + T lymphocytes differentiate from effector to memory cells after antigen clearance, with prolonged IL-2 production characterizing functional cytotoxic T lymphocytes (CTLs). To identify transcription factors associated with sustained IL-2 production, we compared influenza virus–specific and cytomegalovirus-specific CTLs, identifying Basic Leucine …

jp, gb, th (code pays fourni par la source)

CD79A/CD40 intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis

Yuki Takeuchi, Seitaro Terakura, Kohei Ishigiwa, Jakrawadee Julamanee et autres

BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy targeting CD19 has transformed the treatment of hematologic malignancies. The costimulatory domain (CSD) of CAR constructs plays a crucial role in determining T cell metabolism, persistence, and antitumor function. We previously developed a novel CSD …

jp, th (code pays fourni par la source)

Robust CAR T‐cell expansion and superior outcomes in DLBCL patients in complete response at infusion

Ryo Hanajiri, Hiroya Wakabayashi, Kohei Ishigiwa, Fumiya Ohara et autres

Historically, the presence of measurable disease has been considered essential to stimulate CAR T-cell expansion and persistence. However, the kinetics of CAR T cells in patients achieving complete response (CR) before infusion remain poorly understood. This study aimed to evaluate the outcomes …

jp (code pays fourni par la source)

Adjustment of low-dose ATG exposure improves outcomes in allogeneic hematopoietic stem cell transplantation: a prospective multicenter study

Shihomi Kuwano, Seitaro Terakura, Kanae Imai, Shiho Hirano et autres

BACKGROUND AIMS: Antithymocyte globulin (ATG) has been used to prevent the incidence of graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Low-dose ATG can suppress GVHD without increasing the risk of infectious complications. However, the relationship between ATG …

jp (code pays fourni par la source)

Simple and early prediction of severe CAR-T-related adverse events after Axi-cel infusion by initial high fever

Hiroya Wakabayashi, Seitaro Terakura, Kohei Ishigiwa, Fumiya Ohara et autres

jp (code pays fourni par la source)

Analysis of Metabolic Mechanism of CD19CAR-T with CD79A/CD40 Co-Stimulatory Domain Based on Comparison with Established CAR-Ts

Yuki Takeuchi, Seitaro Terakura, Shiho Hirano, Hirofumi Yokota et autres

Introduction: Anti-CD19 chimeric antigen receptor T cell (CD19CAR-T) therapy has achieved significant clinical outcomes and changed treatment strategy in B-cell malignancies. However, recurrence after CAR-T therapy remains a major obstacle due to poor peak expansion and short persistence of CAR-T cells. We …

jp, th (code pays fourni par la source)

Clinical Benefit of Low-Dose Antithymocyte Globulin-Thymoglobulin as Graft-versus-Host Disease Prophylaxis in Patients Receiving Allogeneic Peripheral Blood Stem Cell Transplantation from HLA-Identical Donors

Yuki Takeuchi, Kotaro Miyao, Shuto Negishi, Fumiya Ohara et autres

Graft-versus-host disease (GVHD) is a major complication of allogeneic peripheral blood stem cell transplantation (PBSCT). Previous randomized studies have already shown that the use of several types of antihuman T lymphocyte immune globulin (ATG) as GVHD prophylaxis can reduce the incidence of …

jp (code pays fourni par la source)

Feasibility of trimethoprim/sulfamethoxazole desensitization therapy in hematological diseases

Shuto Negishi, Kotaro Miyao, Fumiya Ohara, Kenta Motegi et autres

jp (code pays fourni par la source)