Erna Snellman

UVA1 exposures change gene expression and circadian time-related protein CRY2 in human skin

Annina Haapasalo, Olivia Liong, Juha Jernman, Lasse Ylianttila et autres

The molecular effects involved in the cellular response to ultraviolet A1 (UVA1) exposures in human skin are incompletely understood. We examined the molecular mechanisms underlying the physiological effects of low-dose UVA1 exposures in human skin in vivo by observing especially the contribution …

fi (code pays fourni par la source)

Infrared-A (IR-A) modulates the p53 pathway and diurnal clock in human skin and subcutaneous adipose tissue in vivo

Iina-Maria Häggqvist, Juha Jernman, Erna Snellman, Petri Kärhä et autres

Infrared-A (IR-A) radiation is thought to protect the skin from damage due to ultraviolet radiation and alter its carcinogenic potential, possibly by preventing keratinocyte apoptosis via p53 pathway modulation. Solar radiation, including IR-A, is a major factor in contributing to the entrainment …

fi (code pays fourni par la source)

Long-term outcome of photodynamic therapy with hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate for low-risk Basal Cell Carcinomas

Mari Salmivuori, M Grönroos, Taneli Tani, Janne Räsänen et autres

BACKGROUND: Non-surgical treatments are cost-effective options for low-risk basal cell carcinomas (BCCs) i.e. superficial or small nodular BCCs located outside the high-risk locations. Hexyl aminolevulinate (HAL) and 5-aminolevulinic acid nanoemulsion (BF-200 ALA) with enhanced penetration depth enables the use of lower concentrations …

fi, se (code pays fourni par la source)

158 Five-year Long-term Results on Photodynamic Therapy of Superficial Basal Cell Carcinoma with Hexyl amonilevulinate, 5-aminolevulinic acid nanoemulsion and Methyl aminolevulinate

Mari Salmivuori, M Grönroos, Tadaaki Tani, Janne Räsänen et autres

fi, se (code pays fourni par la source)

Infrared-A to improve mood: an exploratory study of water-filtered infrared-A (wIRA) exposure

Iina-Maria Häggqvist, Petri Kärhä, Hannu Kautiainen, Erna Snellman et autres

Abstract Diurnal preference to eveningness might predispose to depression. There is preliminary evidence of infrared-A (IR-A) induced whole-body hyperthermia (WBH) in the treatment of depression. In this exploratory study with 19 adults, we investigated the effects of a 20-min exposure of water-filtered …

fi (code pays fourni par la source)

Influence of ultraviolet A1 exposures on mood states: a randomized controlled study

Hannu Haapasalo, Rafael Pasternack, Hannu Kautiainen, Lasse Ylianttila et autres

We investigated the effects of daily ultraviolet A1 (UV-A1, 340-400 nm) exposures on mood states (#R19055, approval on 21 October 2020). Based on our earlier findings of the influence of diurnal preference on mood, we investigated further whether diurnal preference plays a …

fi (code pays fourni par la source)

Narrow-band UVB radiation triggers diverse changes in the gene expression and induces the accumulation of M1 macrophages in human skin

Piia Karisola, Veera Nikkola, Heli Joronen, Lasse Ylianttila et autres

BACKGROUND: The underlying molecular mechanisms that determine the biological effects of UVB radiation exposure on human skin are still only partially comprehended. OBJECTIVES: Our goal is to examine the human skin transcriptome and related molecular mechanisms following a single exposure to UVB …

fi, se (code pays fourni par la source)

Long-Term Outcome of Photodynamic Therapy with Hexyl Aminolevulinate, 5-Aminolevulinic Acid Nanoemulsion and Methyl Aminolevulinate for Low-Risk Basal Cell Carcinomas

Mari Salmivuori, M Grönroos, Taneli Tani, Janne Räsänen et autres

fi, se (code pays fourni par la source)

Melatonin immunoreactivity of epidermal skin is higher in the evening than morning but does not account for erythema sensitivity

Veera Nikkola, Riitta Huotari‐Orava, Heli Joronen, M Grönroos et autres

The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin immunoreactivities in the morning differed from …

fi (code pays fourni par la source)

Diurnal Preference Contributes to Maximal UVB Sensitivity by the Hour of the Day in Human Skin In Vivo

Annina Raita, Iina-Maria Häggqvist, Heli Joronen, Veera Nikkola et autres

There is a functional circadian clock in most of the skin’s cell types (Plikus et al., 2015Plikus M.V. Van Spyk E.N. Pham K. Geyfman M. Kumar V. Takahashi J.S. et al.The circadian clock in skin: implications for adult stem cells, tissue regeneration, …

fi (code pays fourni par la source)

Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma

Niina Korhonen, Leea Ylitalo, Tiina Luukkaala, J Itkonen et autres

The incidence of keratinocyte carcinomas is increasing worldwide and currently there is no standardised strategy for the follow-up of patients with multiple tumours. The objective of this study was to assess the prevalence of premalignant lesions, i.e., actinic keratosis and Bowen's disease, …

fi (code pays fourni par la source)

Hexyl aminolevulinate, 5‐aminolevulinic acid nanoemulsion and methyl aminolevulinate in photodynamic therapy of non‐aggressive basal cell carcinomas: A non‐sponsored, randomized, prospective and double‐blinded trial

Mari Salmivuori, M Grönroos, Taneli Tani, Ilkka Pölönen et autres

BACKGROUND: In the photodynamic therapy (PDT) of non-aggressive basal cell carcinomas (BCCs), 5-aminolevulinic acid nanoemulsion (BF-200ALA) has shown non-inferior efficacy when compared with methyl aminolevulinate (MAL), a widely used photosensitizer. Hexyl aminolevulinate (HAL) is an interesting alternative photosensitizer. To our knowledge, this …

fi, se (code pays fourni par la source)