Vrinda Gote

Systematic AI-Driven Drug Repurposing via Clinical Trial Data Mining: A Framework and Six Cross-Therapeutic Case Studies

Vrinda Gote

ABSTRACT Drug repurposing — the application of approved or shelved compounds to new therapeutic indications — offers a cost- and time-efficient alternative to de novo drug discovery. However, the systematic identification of repurposing candidates from the rapidly expanding body of clinical trial …

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Novel non-aqueous rotavirus vaccine: Formulated for thermostability and easy administration

John W. Langston, M. Carroll, Mary Whalen, Timothy M. Jaw et autres

Rotavirus vaccination has greatly reduced the number of deaths caused by the virus, lowering childhood mortality by an estimated 37% globally. Although low- and middle-income countries (LMIC) demonstrate reduced efficacy than high-income countries, the vaccines still make a significant impact in these …

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Novel non-aqueous rotavirus vaccine: Formulated for thermostability and easy administration

John W. Langston, M. Carroll, Mary M. Whalen, Timothy M. Jaw et autres

Rotavirus vaccination has greatly reduced the number of deaths caused by the virus, lowering childhood mortality by an estimated 37% globally. Although low- and middle-income countries (LMIC) demonstrate reduced efficacy than high-income countries, the vaccines still make a significant impact in these …

Novel non-aqueous rotavirus vaccine: Formulated for thermostability and easy administration

John W. Langston, M. Carroll, Mary M. Whalen, Timothy M. Jaw et autres

Rotavirus vaccination has greatly reduced the number of deaths caused by the virus, lowering childhood mortality by an estimated 37% globally. Although low- and middle-income countries (LMIC) demonstrate reduced efficacy than high-income countries, the vaccines still make a significant impact in these …

From Prediction to Synthesis: Generative AI Architectures and Digital Twins for the Future of Vaccines and Immuno-Oncology

Vrinda Gote

Artificial intelligence (AI) and machine learning (ML) have progressively reshaped vaccinology, enabling the transition from empirical antigen discovery toward computa-tionally guided reverse vaccinology. As the field enters 2026, a further conceptual shift is emerging: the use of generative AI not only to …

A Comprehensive Review of mRNA Vaccines

Vrinda Gote, Pradeep Kumar Bolla, Nagavendra Kommineni, Arun Butreddy et autres

mRNA vaccines have been demonstrated as a powerful alternative to traditional conventional vaccines because of their high potency, safety and efficacy, capacity for rapid clinical development, and potential for rapid, low-cost manufacturing. These vaccines have progressed from being a mere curiosity to …

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Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Vrinda Gote, Anantha Ram Nookala, Pradeep Kumar Bolla, Dhananjay Pal

Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for cancer relapse is the development of multidrug resistance (MDR) hampering the treatment and …

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Octreotide-Targeted Lcn2 siRNA PEGylated Liposomes as a Treatment for Metastatic Breast Cancer

Vrinda Gote, Dhananjay Pal

Lcn2 overexpression in metastatic breast cancer (MBC) can lead to cancer progression by inducing the epithelial-to-mesenchymal transition and enhancing tumor angiogenesis. In this study, we engineered a PEGylated liposomal system encapsulating lipocalin 2 (Lcn2) small interfering RNA (Lcn2 siRNA) for selective targeting …

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Hyaluronic Acid-Targeted Stimuli-Sensitive Nanomicelles Co-Encapsulating Paclitaxel and Ritonavir to Overcome Multi-Drug Resistance in Metastatic Breast Cancer and Triple-Negative Breast Cancer Cells

Vrinda Gote, Amar Deep Sharma, Dhananjay Pal

Active targeting and overcoming multi-drug resistance (MDR) can be some of the important attributes of targeted therapy for metastatic breast cancer (MBC) and triple-negative breast cancer (TNBC) treatment. In this study, we constructed a hyaluronic acid (HA)-decorated mixed nanomicelles-encapsulating chemotherapeutic agent paclitaxel …

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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents

Vrinda Gote

Title from PDF of title page viewed May 25, 2021

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

Vrinda Gote, Abhirup Mandal, Meshal Alshamrani, Dhananjay Pal

Neovascular age-related macular degeneration (AMD) is characterized by an increase in reactive oxygen species (ROS) and pro-inflammatory cytokines in the retinal pigment epithelium cells. The primary purpose of this study was the development of a clear, tacrolimus nanomicellar formulation (TAC-NMF) for AMD. …

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Preparation and characterization of lutein loaded folate conjugated polymeric nanoparticles

Pradeep Kumar Bolla, Vrinda Gote, Mahima Singh, Venkata Yellepeddi et autres

AIM: -glycolide-polyethylene glycol-folate (PLGA-PEG-FOLATE) nanoparticles and evaluate enhanced uptake in SK-N-BE(2) cells. METHODS: Nanoparticles were prepared using O/W emulsion solvent evaporation and characterised using DLS, SEM, DSC, FTIR and in-vitro release. Lutein-uptake in SK-N-BE(2) cells was determined using flow-cytometry, confocal-microscopy and HPLC. …

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