Michael S. Biggers

Synthesis of (+)- and (−)-Tetrabenazine from the Resolution of α-Dihydrotetrabenazine

Karl G. Boldt, Michael S. Biggers, Sharnelle S. Phifer, George A. Brine et autres

Tetrabenazine (1) was reduced with NaBH4 to α-dihydrotetrabenazine (2) and then resolved with di-p-toluoyl-L-tartrate and di-p-toluoyl-D-tartrate to subsequently give (+)- and (−)-α-dihydrotetrabenazine. The enantiomers were oxidized under Swern conditions to prepare samples of (+)-tetrabenazine and (−)-tetrabenazine. The samples were optically pure by …

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ChemInform Abstract: Synthetic Approaches to 2‐(4‐Hydroxy‐7‐chromanyl)benzoic Acids as Antagonists of Leukotriene B4.

Robert Chambers, Kevin M. Koch, Michael S. Biggers, Mukesh Ramchandani

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

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Synthetic approaches to 2-(4-hydroxy-7-chromanyl)benzoic acids as antagonists of leukotriene B4

Robert Chambers, Kevin M. Koch, Michael S. Biggers, Mukesh Ramchandani

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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Lawrence A. Reiter, Kevin M. Koch, Anthony D. Piscopio, Henry J. Showell et autres

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ChemInform Abstract: The SAR of UK‐78,282: A Novel Blocker of Human T Cell Kv1.3 Potassium Channels.

Laurence E. Burgess, Kevin M. Koch, K Cooper, Michael S. Biggers et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

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3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Lawrence A. Reiter, Lawrence S. Melvin, Geraldine L. Crean, Henry J. Showell et autres

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The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

Laurence E. Burgess, Kevin M. Koch, Kelvin Cooper, Michael S. Biggers et autres

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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.

Angela Nguyen, John C. Kath, Douglas C. Hanson, Michael S. Biggers et autres

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Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Allen J. Duplantier, Michael S. Biggers, Robert Chambers, John B. Cheng et autres

In addition to having desirable inhibitory effects on inflammation, anaphylaxis, and smooth muscle contraction, PDE-IV inhibitors also produce undesirable side effects including nausea and vomiting. In general, compounds that inhibit PDE-IV also potently displace [3H]rolipram from a high-affinity binding site in rat …

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CP-123,369: A potent, orally active immunosuppressive agent

Kevin M. Koch, Douglas C. Hanson, M F Newborg, Kelvin Cooper et autres

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The C-32 Triacetyl-L-rhamnose Derivative of Ascomycin: A Potent, Orally Active Macrolactone Immunosuppressant

Kevin M. Koch, M F Newborg, Douglas C. Hanson, Kelvin Cooper et autres

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe C-32 Triacetyl-L-rhamnose Derivative of Ascomycin: A Potent, Orally Active Macrolactone ImmunosuppressantKevin Koch, Michael F. Newborg, Douglas C. Hanson, Kelvin Cooper, Richard M. Shepard, Michael L. Biehl, Michael S. Biggers, Mukesh Ramchandani, Gary Schulte, and Cite this: J. Med. …

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ChemInform Abstract: A Direct Synthesis of Pharmacologically Active ortho‐Substituted Biaryls: A Combined Directed Metalation‐Palladium Catalyzed Cross Coupling Approach Using Aryl Oxazolines or Benzamides.

Kevin M. Koch, Robert Chambers, Michael S. Biggers

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article …

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