Raffaella Spinazzi

Pro-angiogenic activity of Urotensin-II on different human vascular endothelial cell populations

Giovanna Albertin, Diego Guidolin, Elisa Sorato, Raffaella Spinazzi et autres

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Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: Involvement of the vascular endothelial growth factor receptor 2

Diego Guidolin, Giovanna Albertin, Raffaella Spinazzi, Elisa Sorato et autres

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Evidence for a paracrine role of endogenous adrenomedullary galanin in the regulation of glucocorticoid secretion in the rat adrenal gland

Paola G. Andreis, Cinzia Tortorella, Agnieska Ziolkowska, Raffaella Spinazzi et autres

Previous investigations have shown that rat adrenocortical cells are provided with galanin receptors, and galanin stimulates glucocorticoid secretion from dispersed cells. The present study aimed to clarify the possible role of galanin in the physiological regulation of rat adrenal secretory activity. Reverse …

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Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade

Paola G. Andreis, Ludwik K. Malendowicz, Piera Rebuffat, Raffaella Spinazzi et autres

Galanin is a regulatory peptide, which acts via three subtypes of receptors, named GAL-R1, GAL-R2 and GAL-R3. Reverse transcription-polymerase chain reaction demonstrated the expression of GAL-R1 and GAL-R2, but not GAL-R3 mRNAs in dispersed rat adrenal zona fasciculata-reticularis (inner) cells. The immuno-blockade …

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Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro

Raffaella Spinazzi, Giovanna Albertin, Beatrice Nico, Diego Guidolin et autres

Urotensin-II (UII), along its receptor UT-R, is widely expressed in the cardiovascular system, where it exerts regulatory actions under both physiological and pathological conditions. Real-time PCR and immunocytochemistry demonstrated the expression of UII and UT-R as mRNA and protein in rat neuromicrovascular …

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Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat

Witold Malendowicz, Marcin Ruciński, C Macchi, Raffaella Spinazzi et autres

Leptin is an adipose tissue-secreted hormone that acts via specific receptors (Ob-R), of which six isoforms are at present recognized (from Ob-Ra to Ob-Rf). Ob-Rb is the only isoform able to activate JAK-STAT and MAPK signaling cascades. A large body of evidence …

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Ouabain chronic infusion enhances the growth and steroidogenic capacity of rat adrenal zona glomerulosa: the possible involvement of the endothelin system.

Giuliano Neri, Renzo De Toni, Cinzia Tortorella, Piera Rebuffat et autres

Ouabain, an inhibitor of the Na+/K+-ATPase, has been reported to affect the secretory activity of the adrenal cortex, and especially of zona glomerulosa (ZG). However, conflicting results were obtained, depending on the experimental condition used since ouabain appears to interact with angiotensin-II …

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Ouabain chronic infusion enhances the growth and steroidogenic capacity of rat adrenal zona glomerulosa: The possible involvement of the endothelin system

Giuliano Neri, Renzo De Toni, Cinzia Tortorella, Piera Rebuffat et autres

Ouabain, an inhibitor of the Na+/K+-ATPase, has been reported to affect the secretory activity of the adrenal cortex, and especially of zona glomerulosa (ZG). However, conflicting results were obtained, depending on the experimental condition used since ouabain appears to interact with angiotensin-II …

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In vitro culture on Matrigel favors the long-term maintenance of rat zona glomerulosa-cell differentiated phenotype

Raffaella Spinazzi, Lucía Petrelli, Diego Guidolin, Gianni Carraro et autres

Zona glomerulosa (ZG) cells cultured on plastic within few days dedifferentiate losing their capacity to secrete aldosterone (ALDO) in appreciable amounts. Evidence indicates that extracellular matrix modulates the secretory behavior of adrenocortical cells cultured in vitro. Hence, we compared the morphology and …

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Urotensin-II and UII-receptor expression and function in the rat adrenal cortex

Giovanna Albertin, Valentina Casale, Agnieszka Ziółkowska, Raffaella Spinazzi et autres

Urotensin-II (UII) is a potent hypertensive peptide, which has been recognized as an endogenous ligand of the G protein-coupled receptor (GPR)-14, now named UT-R. Real-time PCR demonstrated the expression of UII and UT-R mRNAs in both dispersed and in vitro cultured rat …

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Identification and localization of adrenomedullin-storing cardiac mast cells

Anna Belloni Fortina, Lucía Petrelli, Diego Guidolin, Renzo De Toni et autres

Adrenomedullin (AM), a potent vasodilatory hypotensive peptide, is expressed in the heart, where it is known to play a protective action. Light-microscopy immunocytochemistry (ICC) demonstrated the presence of AM immunoreactivity not only in the coronary-vessel wall and ventricular myocytes of the human …

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Orexins in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis

Raffaella Spinazzi, Paola G. Andreis, Gian Paolo Rossi, Gastone Giovanni Nussdorfer

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