Archi Rungta

KRAS-Targeted Therapies in NSCLC: Resistance, Combination Strategies, and Emerging Clinical Paradigms

Akhil Kapoor, Bipinesh Sansar, Anuj Gupta, Bal Krishna Mishra et autres

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Telemedicine for Cancer Care in Resource-Constrained Settings: Benefits, Barriers, and Implementation Priorities

Akhil Kapoor, Gaurav Redkar, Archi Rungta, Ankita Kapoor et autres

Abstract Cancer care delivery in low- and middle-income countries (LMICs) remains hindered by late diagnosis, geographic disparities, and limited specialist availability. Tele-oncology has gained momentum as a strategy to bridge these gaps, with adoption accelerated during the COVID-19 pandemic. This narrative review …

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The microbiome: A new frontier in cancer immunotherapy - From mechanistic insights to clinical translation

Akhil Kapoor, Archi Rungta

International Journal of Molecular and Immuno Oncology (IJMIO) is a peer-reviewed journal where clinicians and researchers can contribute and keep up with the fast-paced developments in Molecular Biology and Immuno oncology.

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Uncovering Hereditary Risk: Germline Homologous Recombination Repair Variant Spectrum in a Large North Indian Cancer Cohort (INSIGHT-HRR)

Akhil Kapoor, Srushti Uthale, Anamika Chain, Archi Rungta et autres

PURPOSE Homologous recombination repair (HRR) pathway defects are critical drivers of hereditary cancers, yet population-specific prevalence data from India remain limited. Current testing practices disproportionately focus on BRCA1/2 , potentially underidentifying patients with other HRR gene variants who could benefit from targeted …

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The microbiome and its impact on the epigenome in cancer

Akhil Kapoor, Rohit Kumar, Anuj Gupta, Bipinesh Sansar et autres

The complex interplay between the human microbiome and epigenetic regulation represents one of the most rapidly evolving frontiers in cancer biology. The trillions of microorganisms residing in and on the human body collectively termed the microbiota may influence the host gene expression …

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Repeatedly Identified PALB2 Exon 2–3 Large Genomic Deletion in Breast Cancer: Case Report and Clinical Implications

Srushti Uthale, Anamika Chain, Archi Rungta, Rajiv Sarin et autres

Abstract PALB2 is a tumor suppressor gene essential for homologous recombination DNA repair. Pathogenic variants, including large genomic rearrangements (LGRs), predispose to hereditary breast cancer but remain underrecognized. We describe a 34-year-old woman with triple-negative breast cancer carrying a heterozygous PALB2 exon …

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Title: Genetic Counselor Integration Enhancing Uptake of Genetic Testing in Hereditary Cancer Syndromes: A Retrospective Comparative Analysis (GENESIS Study)

Akhil Kapoor, Anamika Chain, Srushti Uthale, Archi Rungta et autres

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Geriatric Population’s Awareness and Attitudes toward Edentulism and Rehabilitation - Influencing Factors and Their Interrelationships: A Cross-sectional Study

Gaurav Redkar, Archi Rungta

Abstract Introduction: This cross-sectional study examines the awareness and attitudes of India’s geriatric population toward edentulism and prosthetic rehabilitation. Conducted from June to August 2024 across diverse regions, 199 participants aged over 60 years were surveyed using a self-administered questionnaire. Results showed …

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Superhero

Archi Rungta

A warrior's family

Archi Rungta

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From Crisis to Clarity: The Essential Role of Genetic Counseling and Emerging Risk-Reducing Strategies in BRCA1-Associated Breast Cancer – A Case Report

Archi Rungta, Anjana Anoop, Srushti Uthale, Shreya Srivastava et autres

Women with BRCA1 pathogenic variants face high lifetime risks of breast and ovarian cancer, requiring complex risk-reducing decisions. We report a 35-year-old woman with node-negative triple-negative breast cancer who achieved a pathologic complete response after neoadjuvant chemotherapy and breast-conserving surgery and was …