Sumei Ren

Alternating Current-Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent

Nibedita Behera, Nhu H. Quach, Rajendra Maity, Dan Lehnherr et autres

Hydrogen isotope exchange (HIE) plays a pivotal role in the synthesis of isotopically labeled compounds, which are widely used in the pharmaceutical industry for drug pharmacokinetic and pharmacodynamic studies. While electrochemical HIE has emerged as a powerful strategy for site-selective labeling of …

us (code pays fourni par la source)

Tripartite motif 46 aggravates MASLD progression by suppressing SGPL1- mediated hepatic lipophagy

Junyong Wang, Li Xiao, Dating Sun, Yaoyao Jin et autres

cn (code pays fourni par la source)

Alternating Current–Driven Hydrogen Isotope Labeling of Aliphatic Amines Using 1,3-Propanedithiol as an Efficient Hydrogen Atom Transfer Reagent

Nibedita Behera, Nhu Quach, Rajendra Maity, Dan Lehnherr et autres

Hydrogen isotope exchange (HIE) plays a pivotal role in the synthesis of isotopically labelled compounds, which are widely used in the pharmaceutical industry for drug pharmacokinetic and pharmacodynamic studies. While electrochemical HIE has emerged as a powerful strategy for site-selective labelling of …

us (code pays fourni par la source)

Orbital coupling nanozymes with enhanced peroxidase-like activity mediate deep thermal ablation/chemodynamic therapy to boost immune response

Ruxia Han, Wenye Zhang, Jiayue Zhang, X J Yang et autres

cn, jp (code pays fourni par la source)

Hot corrosion behavior of a Hf+Cr co-modified (Ni,Pt)Al coating in the mixed salt of Na2SO4–NaCl at 900 °C

Sumei Ren, Peng Ren, Qingwu Wang, Pimin Zhang et autres

cn (code pays fourni par la source)

Enhancing tumor immunotherapy with smart nanoparticles for reprogramming macrophages and blocking the CD47/Sirpα pathway

Zubair Hussain, Shanshan Gou, Xu Liu, Mengyu Li et autres

Immunotherapy has significantly advanced cancer treatment, but the tumor immune microenvironment (TIME) often remains immunosuppressive, limiting therapeutic efficacy. Tumor-associated macrophages (TAMs), particularly M2-like macrophages, play a crucial role in promoting tumor growth and immune evasion. Our study introduces a novel approach using …

cn (code pays fourni par la source)

Hydrogen Isotope Labeling of Pharmaceuticals Via Dual Hydrogen Isotope Exchange Pathways Using CdS Quantum Dot Photocatalyst

Rajendra Maity, Otto M. Dungan, Frédéric A. Perras, Jingwei Li et autres

Isotopic labeling is a powerful technique extensively used in the pharmaceutical industry. By tracking isotope-labeled molecules, researchers gain unique and invaluable insights into the pharmacokinetics and pharmacodynamics of new drug candidates. Hydrogen isotope labeling is particularly important as hydrogen is ubiquitous in …

us (code pays fourni par la source)

Homogenous Palladium-Catalyzed Dehalogenative Deuteration and Tritiation of Aryl Halides with D 2 /T 2 Gas

Jingwei Li, Qiao Lin, Otto M. Dungan, Yue Jin Fu et autres

Hydrogen isotopically labeled compounds have extensive utility across diverse domains, especially in drug discovery and development. However, synthesis of the labeled compounds with exclusive site selectivity and/or high isotope incorporation is challenging. One widely employed method is heterogeneous palladium(0)-catalyzed (such as Pd/C) …

us (code pays fourni par la source)

Hydrogen Isotope Labeling of Pharmaceuticals via Dual Hydrogen Isotope Exchange Pathways

Long Luo, Rajendra Maity, Otto M. Dungan, Frédéric A. Perras et autres

Isotopic labeling is a powerful technique extensively used in the pharmaceutical industry. By tracking isotope-labeled molecules, researchers gain unique and invaluable insights 20 into the pharmacokinetics and pharmacodynamics of new drug candidates. Hydrogen isotope labeling is particularly important as hydrogen is ubiquitous …

us (code pays fourni par la source)

Directed Aromatic Deuteration and Tritiation of Pharmaceuticals by Heavy Alkali Metal Amide Catalysts

Hui‐Zhen Du, Jingwei Li, Stella Christodoulou, Si‐Yuan Li et autres

Deuterium- and tritium-labeled compounds play a significant role in the pharmaceutical development process. Ortho -directed hydrogen isotope exchange (HIE) with transition metal catalysts is one of the most well-developed methods for the labeling of various aromatic compounds, but met with limited success …

cn, us, fr (code pays fourni par la source)

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Sumei Ren, Ping Xu, Jiale He, Hsiu‐Jung Tung et autres

Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis. Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative response that modifies protein structures and functions. Glutaredoxin-1 (GLRX) reverses PSSG by liberating glutathione (GSH). …

us (code pays fourni par la source)

Chemoenzymatic synthesis and immunological evaluation of sialyl-Thomsen-Friedenreich (sTF) antigen conjugate to CRM197

Wei‐Zhao Weng, Sumei Ren, Changcai Teng, Jia Guo et autres

cn (code pays fourni par la source)