Alexandra Beaudry‐Richard

Physiotherapy and Confirmed Disability Improvement in People with Multiple Sclerosis

Kiarra Ning, Matteo Foschi, Melanie Peters, Christian Cordano et autres

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High‐Dose Pulse Glucocorticoid Treatment Prevents White Matter Spinal Cord Pseudoatrophy in Newly Diagnosed Multiple Sclerosis

Simone Sacco, Nico Papinutto, Vinícius Andreoli Schoeps, Shuiting Cheng et autres

OBJECTIVE: Spinal cord (SC) atrophy correlates with and predicts the underlying progressive biology in active and non-active multiple sclerosis (MS), thereby providing a biomarker for clinical trials and patient management. Initiation of disease-modifying therapy (DMT) may be followed by early pronounced central …

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Markers of axonal injury in blood and tissue triggered by acute and chronic demyelination

Ahmed Abdelhak, Christian Cordano, Greg J. Duncan, Katie Emberley et autres

Neuroaxonal injury is a major driver of irreversible disability in demyelinating conditions. Accurate assessment of the association between demyelination and axonal pathology is critical for evaluating and developing effective therapeutic approaches. Measuring neurofilament light chain (NfL) in the blood could putatively allow …

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Is Myelin Detrimental for Axons in Autoimmune Demyelination? (P6-1.008)

Christian Cordano, Isaac P. Samana, Emilee Manske, Hao Yiu et autres

To investigate whether myelin was associated with neuropathological markers of axonal distress in experimental autoimmune encephalomyelitis (EAE) mice treated with vehicle and with clemastine, a compound capable of enhancing remyelination.

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Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults

Alexandra Beaudry‐Richard, Ahmed Abdelhak, Rowan Saloner, Simone Sacco et autres

OBJECTIVE: Vitamin B12 (B12) plays a critical role in fatty- and amino-acid metabolism and nucleotide synthesis. While the association between B12 deficiency and neurological dysfunction is well-known, the exact threshold for adequacy remains undefined in terms of functional impairment and evidence of …

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Acute and Chronic Demyelination Independent of Inflammation Promotes Tissue- and Blood-markers of Neuroaxonal Pathology (S17.010)

Ahmed Abdelhak, Christian Cordano, Katie Emberley, Greg J. Duncan et autres

To determine whether standalone oligodendrocyte and myelin damage do not only increase neuronal vulnerability but are sufficient to cause neuroaxonal injury.

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Synaptic Injury in the IPL of the Retina Is a Predictor of Progression in Multiple Sclerosis (P6-6.003)

Christian Cordano, Sebastian Werneburg, Ahmed Abdelhak, Daniel J. Bennett et autres

To analyze retinal signs of synaptic injury in an animal model of inflammatory demyelination and neurodegeneration, i.e., EAE; to evaluate quantified assessment of a retinal layer with major synaptic component for predicting relentlessly progressive disability in MS; and to use a proteome-wide …

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Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis

Christian Cordano, Sebastian Werneburg, Ahmed Abdelhak, Daniel J. Bennett et autres

While neurodegeneration underlies the pathological basis for permanent disability in multiple sclerosis (MS), predictive biomarkers for progression are lacking. Using an animal model of chronic MS, we find that synaptic injury precedes neuronal loss and identify thinning of the inner plexiform layer …

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Scientific commentary on: “Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies”

Frederike Cosima Oertel, Daniel Isaiah Casillas, Yann Cobigo, Shivany Condor Montes et autres

We read with

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Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis

Ahmed Abdelhak, Pascal Benkert, Sabine A. Schaedelin, W. John Boscardin et autres

Importance: Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity in people with MS (MS); however, data on the association between NfL level …

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Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis

Christian Cordano, Bardia Nourbakhsh, Hao Yiu, Nico Papinutto et autres

BACKGROUND AND OBJECTIVES: The timing of neurodegeneration in multiple sclerosis (MS) remains unclear. It is critical to understand the dynamics of neuroaxonal loss if we hope to prevent or forestall permanent disability in MS. We therefore used a deeply phenotyped longitudinal cohort …

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Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis

Ahmed Abdelhak, Christian Cordano, W. John Boscardin, Eduardo Caverzasi et autres

BACKGROUND: Chronic demyelination is a major contributor to axonal vulnerability in multiple sclerosis (MS). Therefore, remyelination could provide a potent neuroprotective strategy. The ReBUILD trial was the first study showing evidence for successful remyelination following treatment with clemastine in people with MS …

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