Jean‐Rene Ella‐Menye

Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

Mary Prieve, Pierrot Harvie, Sean Monahan, Debashish Roy et autres

We describe a novel, two-nanoparticle mRNA delivery system and show that it is highly effective as a means of intracellular enzyme replacement therapy (i-ERT) using a murine model of ornithine transcarbamylase deficiency (OTCD). Our Hybrid mRNA Technology delivery system (HMT) comprises an …

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Stable and Functionalizable Quantum Dots with a Thin Zwitterionic Carboxybetaine Layer

Wei Yang, Jean‐Rene Ella‐Menye, Tao Bai, Andrew Sinclair et autres

A new type of ligand chemistry, with a zwitterionic carboxybetaine headgroup and a bidentate thiol end group (CBSS), is introduced to promote the stability of quantum dots (QDs) with targeting capability. Results show that QDs are stable over a broad range of …

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Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Arun K. Ghosh, Margherita Brindisi, Yu‐Chen Yen, Emilio L. Cárdenas et autres

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Synthesis and characterization of fluorine-substituted polylactides/glycolides

Razieh Khalifehzadeh, Naeemi Esmaeel, Jean‐Rene Ella‐Menye, Ratner Buddy

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your …

Harnessing isomerization-mediated manipulation of nonspecific cell/matrix interactions to reversibly trigger and suspend stem cell differentiation

Tao Bai, Andrew Sinclair, Fang Sun, Priyesh Jain et autres

Spiropyran-decorated zwitterionic hydrogel realizes reversible manipulation of mesenchymal stem cell fate through programmed light exposure.

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Stealth Surface Modification of Surface-Enhanced Raman Scattering Substrates for Sensitive and Accurate Detection in Protein Solutions

Fang Sun, Jean‐Rene Ella‐Menye, Daniel David Galvan, Tao Bai et autres

Reliable surface-enhanced Raman scattering (SERS) based biosensing in complex media is impeded by nonspecific protein adsorptions. Because of the near-field effect of SERS, it is challenging to modify SERS-active substrates using conventional nonfouling materials without introducing interference from their SERS signals. Herein, …

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Restraint of the Differentiation of Mesenchymal Stem Cells by a Nonfouling Zwitterionic Hydrogel

Tao Bai, Fang Sun, Lei Zhang, Andrew Sinclair et autres

The success of human mesenchymal stem cell (hMSC) therapies is largely dependent on the ability to maintain the multipotency of cells and control their differentiation. External biochemical and biophysical cues can readily trigger hMSCs to spontaneously differentiate, thus resulting in a rapid …

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Restraint of the Differentiation of Mesenchymal Stem Cells by a Nonfouling Zwitterionic Hydrogel

Tao Bai, Fang Sun, Lei Zhang, Andrew Sinclair et autres

Abstract The success of human mesenchymal stem cell (hMSC) therapies is largely dependent on the ability to maintain the multipotency of cells and control their differentiation. External biochemical and biophysical cues can readily trigger hMSCs to spontaneously differentiate, thus resulting in a …

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Achieving One‐Step Surface Coating of Highly Hydrophilic Poly(Carboxybetaine Methacrylate) Polymers on Hydrophobic and Hydrophilic Surfaces

Harihara S. Sundaram, Xia Han, Ann K. Nowinski, Norman D. Brault et autres

It is highly desirable to develop a universal nonfouling coating via a simple one-step dip-coating method. Developing such a universal coating method for a hydrophilic polymer onto a variety of surfaces with hydrophobic and hydrophilic properties is very challenging. This work demonstrates …

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One-Step Dip Coating of Zwitterionic Sulfobetaine Polymers on Hydrophobic and Hydrophilic Surfaces

Harihara S. Sundaram, Xia Han, Ann K. Nowinski, Jean‐Rene Ella‐Menye et autres

Zwitterionic sulfobetaine polymers with a catechol chain end (DOPA-PSB) were applied to a variety of hydrophobic polymer sheets and fibers. In addition, a silica surface was tested as a representative hydrophilic substrate. The polymer-coated surfaces showed significantly lower fouling levels than uncoated …

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Cross-Linked Carboxybetaine SAMs Enable Nanoparticles with Remarkable Stability in Complex Media

Wei Yang, Jean‐Rene Ella‐Menye, Sijun Liu, Tao Bai et autres

A photo-cross-linkable carboxybetaine (CB)-terminated thiol with only one CB headgroup was introduced to modify gold nanoparticles (GNPs) via self-assembled monolayers (SAMs). This CB-terminated thiol consists of three moieties: (a) an anchoring thiol group, which binds directly to the GNP surface, (b) a …

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Sensitive and Fast Detection of Fructose in Complex Media via Symmetry Breaking and Signal Amplification Using Surface-Enhanced Raman Spectroscopy

Fang Sun, Tao Bai, Lei Zhang, Jean‐Rene Ella‐Menye et autres

A new strategy is proposed to sensitively and rapidly detect analytes with weak Raman signals in complex media using surface-enhanced Raman spectroscopy (SERS) via detecting the SERS signal changes of the immobilized probe molecules on SERS-active substrates upon binding of the analytes. …

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