Anna Maria Peri

Evaluating emerging molecular diagnostics for severe infections in neutropenic patients with hematological malignancies

Mariana Pitombeira Libório, Anna Maria Peri, Patrick N. A. Harris

Neutropenia significantly increases infection risk in hematologic malignancies. Clinical signs are often subtle and fever may be the only indicator. Molecular diagnostic methods promise faster, more sensitive pathogen detection compared to conventional methods, aiming to improve timely and appropriate therapy. This review …

Evaluating emerging molecular diagnostics for severe infections in neutropenic patients with hematological malignancies

Mariana Pitombeira Libório, Anna Maria Peri, Patrick N. A. Harris

Neutropenia significantly increases infection risk in hematologic malignancies. Clinical signs are often subtle and fever may be the only indicator. Molecular diagnostic methods promise faster, more sensitive pathogen detection compared to conventional methods, aiming to improve timely and appropriate therapy. This review …

Evaluating emerging molecular diagnostics for severe infections in neutropenic patients with hematological malignancies

Mariana Pitombeira Libório, Anna Maria Peri, P. Harris

INTRODUCTION: Neutropenia significantly increases infection risk in hematologic malignancies. Clinical signs are often subtle and fever may be the only indicator. Molecular diagnostic methods promise faster, more sensitive pathogen detection compared to conventional methods, aiming to improve timely and appropriate therapy. AREAS …

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Clinical Characteristics, Management and Outcomes of Nonintensive Care Unit Candidemia: Subanalysis of the ECMM Candida III Multinational European Observational Cohort Study

Stella Wolfgruber, C García-Vidal, Sarah Sedik, Jon Salmanton-García et autres

Abstract The European Confederation of Medical Mycology Candida III was a pan-European, multicenter observational study of adult patients with blood culture–proven candidemia. Among a total of 632 patients with candidemia across 64 institutions in 20 European countries, a subanalysis of 396 (63%) …

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Time to blood culture positivity predicts metastatic infection in patients with bloodstream infection and correlates with persistence of detectable pathogens in the bloodstream by culture independent systems

Anna Maria Peri, Kevin P. O’Callaghan, Nastaran Rafiei, Mark D. Chatfield et autres

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Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield et autres

BACKGROUND: Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non-infectious fever. T2 magnetic resonance (T2MR) is a culture-independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is …

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Rapid Diagnostic Strategies for Antibiotic-Resistant Bacteria Causing Bloodstream Infection

Anna Maria Peri, Patrick N. A. Harris, Ritu Banerjee

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Novel technologies for the diagnosis of bloodstream infection: performance and clinical application

Anna Maria Peri

Integrating omics techniques and culture-independent systems may improve the detection of persistent candidemia: data from an observational study

Anna Maria Peri, Kevin P. O’Callaghan, Nastaran Rafiei, Haakon Bergh et autres

INTRODUCTION: Blood cultures have low sensitivity for candidemia. Sensitivity can be improved by the culture-independent system T2 Magnetic Resonance (T2). SeptiCyte RAPID is a host response assay quantifying the risk of infection-related inflammation through a scoring system (SeptiScore). We investigate the performance …

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Rapid Diagnostic Tests and Antimicrobial Stewardship Programs for the Management of Bloodstream Infection: What Is Their Relative Contribution to Improving Clinical Outcomes? A Systematic Review and Network Meta-analysis

Anna Maria Peri, Mark D. Chatfield, Weiping Ling, Luis Furuya‐Kanamori et autres

BACKGROUND: Evidence about the clinical impact of rapid diagnostic tests (RDTs) for the diagnosis of bloodstream infections is limited, and whether RDT are superior to conventional blood cultures (BCs) embedded within antimicrobial stewardship programs (ASPs) is unknown. METHODS: We performed network meta-analyses …

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Host response signature trends in bacteraemia – authors’ response

Anna Maria Peri, Patrick N. A. Harris, David L. Paterson

Dear Editor,We read with interest the letter from Brandon et al. [1] in response to our article ‘Host response signature trends in persistent bacteraemia and metastatic infection due to Staphylococ...

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Host response signature trends in persistent bacteraemia and metastatic infection due to Staphylococcus aureus and Gram-negative bacilli: a prospective multicentre observational study

Anna Maria Peri, Nastaran Rafiei, Kevin P. O’Callaghan, Anna Brischetto et autres

Background A prompt diagnosis of bacteraemia and sepsis is essential. Markers to predict the risk of persistent bacteraemia and metastatic infection are lacking. SeptiCyte RAPID is a host response assay stratifying patients according to the risk of infectious vs sterile inflammation through …

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