Elizabeth R. Jenny-Avital

Severe Mpox Among People With Advanced Human Immunodeficiency Virus Receiving Prolonged Tecovirimat in New York City

Elizabeth A. Garcia, Mary M K Foote, Tristan D. McPherson, Maura K. Lash et autres

Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, …

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PERICARDIAL EFFUSION WITH FIBRIN STRANDING FROM HHV-8 ASSOCIATED PRIMARY EFFUSION LYMPHOMA: AN UNUSUAL FINDING OF A RARE DISEASE

Adhya Mehta, Rishi Chandiramani, Elizabeth R. Jenny-Avital, Timothy F. Christian

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Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022

Maureen J. Miller, Shama Cash‐Goldwasser, Grace E. Marx, Caroline A. Schrodt et autres

Engaging all persons with HIV in sustained care remains a critical public health priority.

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Severe Multisystem Inflammatory Symptoms in 2 Adults after Short Interval between COVID-19 and Subsequent Vaccination

Elizabeth R. Jenny-Avital, Ruth A. Howe

T he Centers for Disease Control and Prevention (CDC) recommends coronavirus disease (CO-VID-19) vaccination after natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection once acute symptoms resolve.We encountered 2 adults at Jacobi Medical Center (Bronx, NY, USA) who experienced severe febrile …

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Human Immunodeficiency Virus Guidelines: Are We There Yet?

Elizabeth R. Jenny-Avital

(See the Viewpoints by Berzow et al on pages 503–9 and the Major Article by Raugi et al on pages 369–78.) Human immunodeficiency virus type 2 (HIV-2), the “second” [1] or the “forgotten” [2] AIDS virus, is like an eclipsed poor relation—always …

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Capsular glycan recognition provides antibody-mediated immunity against tuberculosis

Tingting Chen, Caroline Blanc, Yanyan Liu, Elise Ishida et autres

A better understanding of all immune components involved in protecting against Mycobacterium tuberculosis infection is urgently needed to inform strategies for novel immunotherapy and tuberculosis (TB) vaccine development. Although cell-mediated immunity is critical, increasing evidence supports that antibodies also have a protective …

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Effects of anticoagulants and Ficoll on human serum antibody reactivities and functions against Mycobacterium tuberculosis

Nicholas J. Gadsden, Yanyan Liu, Stephanie B. Gati, Tingting Chen et autres

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Pneumococcus—Still an Opportunist for People Living With Human Immunodeficiency Virus—Now What?

Elizabeth R. Jenny-Avital

(See the Major Article by Garcia Garrido et al on pages 41–50.) The disproportionate occurrence of a pathogen in “risk” groups characterizes the pathogen as relatively opportunistic and the “risk” as a relative immunodeficiency. Garcia-Garrido et al [1] show that pneumococcal infection …

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Central nervous system histoplasmosis

Joseph L. Wheat, Thein Myint, Ying Guo, Phebe Kemmer et autres

Central nervous system (CNS) involvement occurs in 5 to 10% of individuals with disseminated histoplasmosis. Most experience has been derived from small single center case series, or case report literature reviews. Therefore, a larger study of central nervous system (CNS) histoplasmosis is …

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Soluble CD14 as a Diagnostic Biomarker for Smear-Negative HIV-Associated Tuberculosis

Yanyan Liu, Okechukwu C. Ndumnego, Tingting Chen, Ryung S. Kim et autres

Sputum smear-negative HIV-associated active tuberculosis (TB) is challenging to diagnose. CD14 is a pattern recognition receptor that is known to mediate monocyte activation. Prior studies have shown increased levels of soluble CD14 (sCD14) as a potential biomarker for TB, but little is …

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Care of HIV Patients

Elizabeth R. Jenny-Avital

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Identification of Antibody Targets for Tuberculosis Serology using High-Density Nucleic Acid Programmable Protein Arrays

Lusheng Song, Garrick L Wallstrom, Xiaobo Yu, Marika Hopper et autres

Better and more diverse biomarkers for the development of simple point-of-care tests for active tuberculosis (TB), a clinically heterogeneous disease, are urgently needed. We generated a proteomic Mycobacterium tuberculosis ( Mtb ) High-Density Nucleic Acid Programmable Protein Array (HD-NAPPA) that used a …

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