Anthony Coon

Early intervention with secukinumab prevents epigenetic scar development in new-onset psoriasis: STEPIn mechanistic substudy results

Johann E. Gudjonsson, Katharina Bier, Swann Gaulis, Lam C. Tsoi et autres

BACKGROUND: Psoriasis is a common chronic inflammatory skin disease characterized by recurrent flares at previously affected locations. Although biologics targeting IL-17 or IL-23 effectively suppress active disease, they rarely result in long-term remission, suggesting that clinically resolved skin retains molecular changes predisposing …

us, ch, se, dk (code pays fourni par la source)

CRISPR/Cas9 Editing of Human Keratinocytes for Organotypic Modeling of Genetic Epidermal Disorders

Anthony Coon, Jessica L. Ayers, C. Cole, Afua Tiwaa et autres

us (code pays fourni par la source)

Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis

Rundong Jiang, Joseph Kirma, J.L. Fox, Xianying Xing et autres

Generalized pustular psoriasis (GPP) is a severe subtype of psoriasis characterized by epidermal neutrophil infiltration, often presenting as acute, potentially life-threatening flares. However, the characterization of the immune micro-environment in GPP lesions remains largely unknown. Here, we use single-cell RNA profiling to …

cn, us, fr (code pays fourni par la source)

RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis

Rezvan Parvizi, Zhiyun Gong, Helen Jarnagin, Diana M. Toledo et autres

OBJECTIVES: The activation of runt-related transcription factor 1 (RUNX1) in fibroblasts has been implicated in wound healing and fibrosis; however, the role of RUNX1 in the fibrotic progression of the autoimmune disease systemic sclerosis (SSc) remains known. METHODS: Leveraging gene expression, genome-wide …

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244 A human epidermal model of keratin 5 loss-of-function reveals potential therapeutic strategies for epidermolysis bullosa simplex

Kerstin Schmidt, A. Tiwaa, Anthony Coon, MK Sarkar et autres

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Positionally distinct interferon-stimulated dermal immune-acting fibroblasts drive neutrophil recruitment in Sweet’s syndrome 4440

Kellen Cavagnero, Julie Albright, Lam C. Tsoi, Brian Hinds et autres

Abstract Description Sweet’s syndrome is a poorly understood inflammatory skin disease characterized by neutrophil infiltration to the dermis. Single-nucleus and bulk transcriptomics of archived FFPE clinical samples revealed elevated plasmacytoid dendritic cells and a prominent interferon signature in Sweet’s syndrome skin that …

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The endoplasmic reticulum autophagy receptor TEX264 drives epidermal differentiation and is dysregulated in Darier disease

Christopher J. Johnson, Afua Tiwaa, Arti Parihar, E. Esteban de Antonio et autres

Differentiating keratinocytes break down their organelles and nuclei to become the compacted cornified layers of the epidermal barrier in a poorly understood catabolic process. Live confocal imaging of stratified human organotypic epidermis revealed endoplasmic reticulum (ER) fragmentation and lysosomal engulfment in the …

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0050 Unveiling the IL-36/IFNK axis in sex-biased generalized pustular psoriasis

M.K. Sarkar, Anthony Coon, C. Cole, Rundong Jiang et autres

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0501 Keratin 5 knockout dysregulates keratinocyte differentiation and epidermal morphogenesis and reveals potential pathogenic drivers of epidermolysis bullosa simplex

Kerstin Schmidt, A. Tiwaa, Anthony Coon, Mrinal K. Sarkar et autres

us (code pays fourni par la source)

0583 Generation of novel immortalized keratinocyte lines through overexpression of human telomerase and CRISPR-Cas9 KO of CDKN2A

Anthony Coon, C. Cole, Rui Jiang, Mrinal K. Sarkar et autres

0627 Single-cell analyses of secondary syphilis in skin reveals implications for immune evasion and transmission

Joseph Kirma, Irène Gallais Sérézal, M.K. Sarkar, Chad Cole et autres

Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

James G. Krueger, Mrinal K. Sarkar, Mark Lebwohl, Akimichi Morita et autres

People with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares.

us, jp, ca, gb, cn, de (code pays fourni par la source)