Е. А. Мукашева

Оценка иммуногенности препаратов против вируса гриппа на основе классических и самоамплифицирующихся РНК

Д. А. Кунык, Е. П. Мазунина, Е. А. Мукашева, А. В. Игнатьева et autres

Высокая изменчивость вируса гриппа и ограниченная гибкость инактивированных вакцин обусловливают необходимость в создании новых более эффективных профилактических препаратов. РНК-платформа — одна из наиболее перспективных для создания вакцин нового поколения против респираторных инфекций. Целью работы было сравнить иммуногенность двух экспериментальных препаратов на основе …

Features of population immunity in elderly individuals against influenza and ARVI pathogens in the 2024–2025 season

Anna Nozdracheva, T. P. Gotvyanskaya, E.I. Burtseva, Elizaveta N. Vetrova et autres

Data on the state of herd immunity is of key importance for identifying the features of the epidemic process, forecasting its development, as well as for substantiating measures for specific and non-specific prevention of influenza and acute respiratory viral infections among the …

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Assessment of Population Immunity to Influenza and Acute Respiratory Viral Infections of Moscow Population during 2023–2024 Epidemic Season

Vladimir А. Gushchin, Т. А. Семененко, Burtseva Ei, Yana V. Simakova et autres

Relevance. Acute respiratory viral infections (ARVI) annually occupy leading positions in terms of morbidity and economic damage both in the world and in the Russian Federation. From an epidemiological point of view, it is important to constantly monitor the circulation of influenza …

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Epidemic season 2023–2024: the palette of ARVI pathogens in some territories of the Russian Federation and WHO regions

Burtseva Ei, N. V. Breslav, Е. А. Мукашева, Kirill G. Krasnoslobodtsev et autres

The purpose of this work was to determine the characteristics of the circulation of acute respiratory viral infection (ARVI) pathogens during the epidemic season of 2023-2024 in the WHO regions and Russian Federation. MATERIALS AND METHODS: The article uses virological, immunological, and …

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Analysis of the association of influenza clinical course with single nucleotide polymorphisms in genes affecting the interferon-λ3 production

Л. И. Николаева, Maya D. Stuchinskaya, Kristina P. Telepenina, Nadezhda G. Shevchenko et autres

Introduction. Predisposition to different courses of the infectious process is largely associated with the polymorphisms in human genome, especially in genes encoding proteins of the immune system. In the early stages of influenza infection such components of innate immunity as interferons I …

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Immunogenicity and Efficacy of Combined mRNA Vaccine Against Influenza and SARS-CoV-2 in Mice Animal Models

Elena P. Mazunina, Vladimir А. Gushchin, Evgeniia N. Bykonia, Denis A. Kleymenov et autres

Background. The combined or multivalent vaccines are actively used in pediatric practice and offer a series of advantages, including a reduced number of injections and visits to the doctor, simplicity of the vaccination schedule and minimization of side effects, easier vaccine monitoring …

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STUDYING THE ASSOCIATION OF ALLELIC VARIANTS OF THE GENES IFNL3 AND IFNL4 WITH COVID-19

Л. И. Николаева, Maya D. Stuchinskaya, Nadezhda G. Shevchenko, Kirill G. Krasnoslobodtsev et autres

The purpose of the work was to investigate the association of individual allelic variants of the polymorphic loci of genes IFNL3 (rs8099917 T/G) and IFNL4 (rs12979860 C/T) with the se-verity of COVID-19. No reliable association was found between individual allelic variants and …

Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response

Elena P. Mazunina, Vladimir А. Gushchin, Denis A. Kleymenov, Andrei E. Siniavin et autres

Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. Vaccination is generally accepted as the most effective strategy for influenza prevention. While current influenza vaccines are effective, they still have limitations, …

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Properties of influenza viruses that caused epidemic increases in morbidity in Russia and countries of the world during 2022–2023. The effectiveness of vaccine prophylaxis

Burtseva Ei, Ludmila V. Kolobukhina, Anna D. Panova, Е. А. Мукашева et autres

The purpose of this work was to determine the characteristics of the circulation of various viral respiratory pathogens during the epidemic season 2022–2023 against the background of the ongoing evolutionary variability of SARS-CoV-2. Materials and methods. The article uses methods used in …

Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response

Elena P. Mazunina, Vladimir А. Gushchin, Denis A. Kleymenov, Andrey E. Sinyavin et autres

ABSTRACT Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. It also imposes a substantial economic burden through increased absenteeism during periods of active pathogen circulation. Vaccination is generally accepted as …

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Association of polymorphic variants of hemostatic system genes with the course of COVID-19

Л. И. Николаева, Maya D. Stuchinskaya, Anna V. Dedova, Nadezhda G. Shevchenko et autres

Introduction. COVID-19 is characterized by a varied clinical course. The aim of the work was to identify associations of SNPs of hemostatic system genes with COVID-19. Materials and methods. DNA was isolated from patients (n=117) and healthy participants (n=104). All infected patients …

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Epidemic season 2021–2022: Frequency of co-infection by respiratory viral pathogens

Burtseva Ei, Anna D. Panova, Ludmila V. Kolobukhina, Anna V. Ignatjeva et autres

BACKGROUND: This study was conducted to determine the characteristics of various viral respiratory pathogens spreading during the epidemic season 20212022 and the frequency of co-infection with SARS-CoV-2 and influenza. AIM: To assess the development of the influenza epidemic and frequency of cases …

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