Hideo Takeshima

Phase II trial of pathology-based tripartite treatment stratification for patients with CNS germ cell tumors: A long-term follow-up study

Hirokazu Takami, Masao Matsutani, Tomonari Suzuki, Kazuhiko Takabatake et autres

BACKGROUND: A previous Phase II clinical trial, conducted from 1995 to 2003, evaluated CNS germ cell tumors (GCTs) using a three-group treatment stratification based on histopathology. The primary objective of the study was to assess the long-term efficacy of standardized treatment regimens, …

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GCT-16. LONG-TERM OUTCOMES AND COMPLICATION MANAGEMENT IN CNS GERM CELL TUMORS: INSIGHTS FROM A PHASE II HISTOPATHOLOGY-STRATIFIED TREATMENT TRIAL

Hirokazu Takami, Ryo Nishikawa, Tomonari Suzuki, Kazuhiko Takabatake et autres

Abstract BACKGROUND This detailed examination merges outcomes from a Phase II clinical trial targeting central nervous system (CNS) germ cell tumors (GCTs) conducted between 1995 and 2003. It evaluates the impact of histopathologically driven treatment modalities on survival, recurrence, and post-treatment life …

jp (code pays fourni par la source)

Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma

Kiyotaka Yokogami, Takashi Watanabe, Shinji Yamashita, Asako Mizuguchi et autres

PURPOSE: Meningiomas are the most common type of brain tumors and are generally benign, but malignant atypical meningiomas and anaplastic meningiomas frequently recur with poor prognosis. The metabolism of meningiomas is little known, so few effective treatment options other than surgery and …

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Targeting cholesterol biosynthesis for AT/RT: comprehensive expression analysis and validation in newly established AT/RT cell line

Fumitaka Matsumoto, Kiyotaka Yokogami, Ai Y. Yamada, Hiroshi Moritake et autres

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Induced senescence and calcification in anaplastic meningioma

Kiyotaka Yokogami, Takashi Watanabe, Shinji Yamashita, Asako Mizuguchi et autres

Abstract Purpose. Meningiomas are the most common type of brain tumors and are generally benign, but malignant atypical meningiomas and anaplastic meningiomas frequently recur with poor prognosis. The metabolism of meningiomas is little known, so few effective treatment options other than surgery …

jp (code pays fourni par la source)

Epidemiological Study of Metastatic Brain Tumors in Miyazaki Prefecture: A Regional 10-year Survey in Southern Japan

Go Takeishi, Shinji Yamashita, Fumitaka Matsumoto, Kiyotaka Saito et autres

Advances in cancer treatment have improved the survival of patients with cancer, with a concomitant increase in the proportion of patients with metastatic brain tumors (MBTs). In this study, we used cancer registries established in Japan after 2016 and available patient data …

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CTNI-72. PHASE II TRIAL OF PATHOLOGY-BASED THREE-GROUP TREATMENT STRATIFICATION FOR PATIENTS WITH CNS GERM CELL TUMORS: A LONG-TERM FOLLOW-UP STUDY

Hirokazu Takami Fulvio D'Angelo, Tomonari Suzuki, Kazuhiko Takabatake, Takamitsu Fujimaki et autres

Abstract BACKGROUND Phase II clinical trial funded by Ministry of Health, Labour and Welfare from 1995 to 2003 evaluated efficacy of pathology-based three-group treatment stratification for CNS germ cell tumors (GCTs). We here present long-term follow-up results. METHODS Total 228 cases were …

jp (code pays fourni par la source)

Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors

Hirokazu Takami, Kaishi Satomi, Kohei Fukuoka, Taishi Nakamura et autres

We have previously reported that 12p gain may predict the presence of malignant components and poor prognosis for CNS germ cell tumor (GCT). Recently, 3p25.3 gain was identified as an independent predictor of poor prognosis for testicular GCT. Eighty-one CNS GCTs were …

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Rare solitary pituitary metastasis of maxillary ameloblastic carcinoma: illustrative case

Souma Arikawa, Takashi Watanabe, Hideki Yamaguchi, Yuichiro Z. Sato et autres

BACKGROUND: Ameloblastic carcinoma (AC) is a rare odontogenic carcinoma with histological features resembling ameloblastoma. Metastasis to distant organs and direct expansion into the skull base structures are associated with a poor clinical outcome. This rare case of AC metastasis to the pituitary …

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P10.05.A INDUCED SENESCENCE AND CALCIFICATION TO ANAPLASTIC MENINGIOMA

Kiyotaka Yokogami, Takashi Watanabe, Aya Mizuguchi, Satoshi Yamashita et autres

Abstract BACKGROUND Although the majority of meningiomas are slow-growing and benign, atypical and anaplastic meningiomas behave aggressively with a penchant for recurrence. The 5-year risk of progression for incompletely resected meningiomas is over 80 percents. Specifically, the 5-year survival rates are 78-91% …

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P03.03.A T2-FLUID-ATTENUATED INVERSION RECOVERY MISMATCH SIGN IN LOWER-GRADE GLIOMAS: CORRELATION WITH PATHOLOGICAL AND MOLECULAR FINDINGS

Shinji Yamashita, Hideo Takeshima, Yoshihito Kadota, Minako Azuma et autres

Abstract BACKGROUND After the new molecular-based classification was reported to be useful for predicting prognosis, the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign has gained interest as one of the promising methods for detecting lower-grade gliomas (LGGs) with isocitrate dehydrogenase (IDH) mutations and …

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Novel Strategy Involving High-Dose Chemotherapy with Stem Cell Rescue Followed by Intrathecal Topotecan Maintenance Therapy without Whole-Brain Irradiation for Atypical Teratoid/Rhabdoid Tumors

Ai Y. Yamada, Mariko Kinoshita, Sachiyo Kamimura, Takashi Jinnouchi et autres

Atypical teratoid/rhabdoid tumor (AT/RT) is a rare aggressive central nervous system tumor that typically affects children under three years old and has poor survival with a high risk for neurologic deficits. The primary purpose of this study was to successfully treat the …

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