Hideki Yamaguchi

Cell Biology of Cancer Peritoneal Metastasis: Multiclonal Seeding and Peritoneal Tumor Microenvironment

Hideki Yamaguchi, Makoto Miyazaki

Peritoneal metastasis, also known as peritoneal dissemination or carcinomatosis, refers to the spread of cancer to the peritoneum that lines the abdominal and pelvic cavities and covers the abdominal organs. Peritoneal metastasis typically occurs in advanced cancers of abdominal origin, most commonly …

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A System of Bidirectional Power Routing Toward Multi-energy Management

Shiu Mochiyama, Ryo Takahashi, Yoshihiko Susuki, Tsutomu Wakabayashi et autres

In this paper, we propose a system of bidirectional power routing for inter-house multi-energy management systems that utilize electricity and hydrogen as energy carriers. The key is to share private facilities such as photovoltaic panels and batteries among a group of houses …

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A System of Bidirectional Power Routing Toward Multi-energy Management

Shiu Mochiyama, Ryo Takahashi, Yoshihiko Susuki, Tsutomu Wakabayashi et autres

In this paper, we propose a system of bidirectional power routing for inter-house multi-energy management systems that utilize electricity and hydrogen as energy carriers. The key is to share private facilities such as photovoltaic panels and batteries among a group of houses …

Heterocellular Adhesion in Cancer Invasion and Metastasis: Interactions between Cancer Cells and Cancer-Associated Fibroblasts

Hideki Yamaguchi, Makoto Miyazaki

Cancer invasion is a requisite for the most malignant progression of cancer, that is, metastasis. The mechanisms of cancer invasion were originally studied using in vitro cell culture systems, in which cancer cells were cultured using artificial extracellular matrices (ECMs). However, conventional …

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Rare solitary pituitary metastasis of maxillary ameloblastic carcinoma: illustrative case

Souma Arikawa, Takashi Watanabe, Hideki Yamaguchi, Yuichiro Z. Sato et autres

BACKGROUND: Ameloblastic carcinoma (AC) is a rare odontogenic carcinoma with histological features resembling ameloblastoma. Metastasis to distant organs and direct expansion into the skull base structures are associated with a poor clinical outcome. This rare case of AC metastasis to the pituitary …

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Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis

Makoto Miyazaki, Ayaka Nakabo, Yoshiko Nagano, Yuko Nagamura et autres

Peritoneal metastasis is one of the most frequent causes of death in several types of advanced cancers; however, the underlying molecular mechanisms remain largely unknown. In this study, we exploited multicolor fluorescent lineage tracking to investigate the clonality of peritoneal metastasis in …

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Membrane structures, dynamics, and shaping in invadopodia and podosomes

Hideki Yamaguchi

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Receptor Tyrosine Kinases Amplified in Diffuse-Type Gastric Carcinoma: Potential Targeted Therapies and Novel Downstream Effectors

Hideki Yamaguchi, Yuko Nagamura, Makoto Miyazaki

Gastric cancer (GC) is a major cause of cancer-related death worldwide. Patients with an aggressive subtype of GC, known as diffuse-type gastric carcinoma (DGC), have extremely poor prognoses. DGC is characterized by rapid infiltrative growth, massive desmoplastic stroma, frequent peritoneal metastasis, and …

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Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer

Takuya Shirakihara, Hideki Yamaguchi, Tadashi Kondo, Masakazu Yashiro et autres

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Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma

Shingo Miyamoto, Yoshiko Nagano, Makoto Miyazaki, Yuko Nagamura et autres

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SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling

Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Arata Tomiyama et autres

Diffuse-type gastric carcinoma (DGC) exhibits aggressive progression associated with rapid infiltrative growth, massive fibrosis, and peritoneal dissemination. Gene amplification of Met and fibroblast growth factor receptor 2 (FGFR2) receptor tyrosine kinases (RTKs) has been observed in DGC. However, the signaling pathways that …

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PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification

Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Masako Yuki et autres

Met gene amplification has been found in a subset of malignant carcinomas, including diffuse-type gastric carcinoma (DGC), which has a poor prognosis owing to rapid infiltrative invasion and frequent peritoneal dissemination. Met is considered a promising therapeutic target for DGC. However, DGC …

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