Accès ouvert
2026
article
OpenAlex
Miles Martinati, Giovanni Batignani, Gaia De Maria, Giancarlo Fabrizi et autres
Perylene bisimides (PBIs) are prime building blocks for functional supramolecular architectures, yet mapping their salt-induced self-assembly kinetics under physiological conditions remains challenging, due to rapid aggregation and overwhelming fluorescence. Here, we combine fluorescence stopped-flow kinetics and stimulated Raman scattering (SRS) spectroscopy to …
it, cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Antonia Intze, Raffaella Polito, Maria Eleonora Temperini, Alessio Incocciati et autres
Dihydrolevoglucosenone (DHL) shows great promise as an alternative to conventional toxic organic solvents widely used for industrial purposes. In this framework, evaluating the potential of DHL (commercially known as Cyrene) as a solvent for dissolving proteins is of great importance. Here, the …
it
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sofia Botta, Roberta Piacentini, Chiara Cappelletti, Alessio Incocciati et autres
Gallic acid, a major phenolic compound in wine, significantly influences its sensory profile and health-related properties, making its accurate measurement essential for both enological and nutritional studies. In this context, a derivatization protocol for gallic acid using ethyl chloroformate (ECF) was developed …
it
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Bartłomiej Taciak, Maciej Białasek, Małgorzata Kubiak, Ilona Marszałek et autres
Treatment of solid tumors remains challenging and therapeutic strategies require continuous development. Tumor-infiltrating macrophages play a pivotal role in tumor dynamics. Here, we present a Macrophage-Drug Conjugate (MDC) platform technology that enables loading macrophages with ferritin-drug complexes. We first show that macrophages …
pl, ch, de, it, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli et autres
In this study, we focused on the computational analysis of a selected single-point mutation identified by a NGS screening panel in the TET2 enzyme classified as “variant of uncertain clinical significance.” The mutation, namely Q1084P, occurs at the interface between TET2, an …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alberto Macone, Chiara Cappelletti, Alessio Incocciati, Roberta Piacentini et autres
Over the past two decades, ferritin has emerged as a promising nanoparticle for drug delivery, catalyzing the development of numerous prototypes capable of encapsulating a wide array of therapeutic agents. These ferritin-based nanoparticles exhibit selectivity for various molecular targets and are distinguished …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alessio Incocciati, Chiara Cappelletti, Silvia Masciarelli, Francesca Liccardo et autres
Abstract Hypercholesterolemia, characterized by elevated low‐density lipoprotein (LDL) cholesterol levels, is a significant risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol metabolism by regulating LDL receptor degradation, making it a therapeutic target for …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Roberta Piacentini, Alberto Boffi, Edoardo Milanetti
Lactoferrins and lactoferrin-derived peptides display numerous functions linked to innate immunity in mammalians, spanning from antimicrobial to anti-inflammatory and immunomodulatory actions, and even demonstrate antitumor properties. To date, the proposed mechanisms for their biological actions are varied, although the molecular basis that …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore et autres
The development of methods able to modulate the binding affinity between proteins and peptides is of paramount biotechnological interest in view of a vast range of applications that imply designed polypeptides capable to impair or favour Protein-Protein Interactions. Here, we applied a …
it
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Alessio Incocciati, Jan Kubeš, Roberta Piacentini, Chiara Cappelletti et autres
Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic agents. In this study, we successfully genetically engineered human H ferritin by incorporating 4 or 6 …
it, cz
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Luisa Affatigato, Alice Sciortino, Giuseppe Sancataldo, Alessio Incocciati et autres
Abstract Ferritin nanoparticles play many important roles in theranostic and bioengineering applications and have been successfully used as nanovectors for the targeted delivery of drugs due to their ability to specifically bind the transferrin receptor (TfR1, or CD71). They can be either …
it
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Roberta Piacentini, Laura Centi, Mattia Miotto, Edoardo Milanetti et autres
The present investigation focuses on the analysis of the interactions among human lactoferrin (LF), SARS-CoV-2 receptor-binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2) receptor in order to assess possible mutual interactions that could provide a molecular basis of the reported preventative …
it
(code pays fourni par la source)