Chun‐Suo Yao

A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance

Ping Li, Xin hai Yin, Xinzhu Wen, Xuyu Li et autres

Introduction: Dysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. Poorly functioning regulatory T cells (Tregs) lead to extreme situations where self-tolerance is robustly disrupted. However, there are many uncertainties regarding its immunosuppressive pathways, …

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Efficient total synthesis of dehydro-δ-viniferin through metal–halogen exchange cyclization

Qibin Zhu, Xueying Zhou, Chun‐Suo Yao

-PrMgCl·LiCl facilitate metal-halogen exchange cyclization and dehalogenation. This synthetic approach, scalable for the production of analogs, was successfully conducted for the first time in multigram quantities.

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Iodonium Ion-Induced Cyclization and Aryl Migration of ortho-Hydroxystilbenes for the Synthesis of 3-Aryl-2,3-dihydrobenzofuran

Ying Chen, Yiyao Fan, Yanqiu Li, Chun‐Suo Yao

A facile and versatile protocol for the efficient synthesis of 3-aryl-2,3-dihydrobenzofuran (ADB) has been reported first. This reaction features the cyclization and aryl migration reaction of ortho -hydroxystilbene in ethanol, which is mediated by an iodonium ion, under ambient conditions. A class …

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[The effective analysis of refractory esophageal stricture after endoscopic mucosal dissection of early esophageal cancer treated by endoscopic radiotomy combined with local injection of triamcinolone acetonide].

Chun‐Suo Yao, H R Wu, Y Liu, G Q Wang

Refractor esophageal stenosis after endoscopic submucosal dissection of early esophageal carcinoma is a difficult clinical problem. To verify the effect of endoscopic radial incision combined local triamcinolone injection to treat refractory esophageal stenosis, we retrospectively analyzed 7 patients diagnosed with refractory esophageal …

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Practical and efficient total synthetic route of the resveratrol dimer (±)-ε-viniferin

Fubao Su, Qibin Zhu, Ying Chen, Yanqiu Li et autres

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A concise and efficient total synthetic route of active stilbene dimer (±)- ε -viniferin

Qibin Zhu, Binhao Teng, Ying Chen, Fubao Su et autres

Demethylation of the key intermediate methyl 3-arylbenzofuran-4-carboxylate resulted in a concise and efficient procedure for the total synthesis of active natural stilbene dimer (±)- ε -viniferin with MOM as a protecting group.

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Multiple Components Rapidly Screened from Perilla Leaves Attenuate Asthma Airway Inflammation by Synergistic Targeting on Syk

Hui Yang, Wei Sun, Pei Ma, Chun‐Suo Yao et autres

Background: Perilla frutescens (L.) Britt., a classic medicinal plant, has been demonstrated to have anti-inflammatory and anti-allergic effects in asthma. Perilla leaves extract (PLE) exerted significant therapeutic effect against allergic asthma inflammation through Syk inhibition. But the active chemical ingredients from PLE …

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Total synthesis of the active resveratrol dimer dehydro-δ-viniferin

Binhao Teng, Qibin Zhu, Yiyao Fan, Chun‐Suo Yao

A new approach for the total synthesis of the active stilbene dimer dehydro-δ-viniferin has been achieved in 9 steps with methyl 4-hydroxybenzoate and 3,5-dihydroxyacetophenone as starting materials. The key feature of the method is the amberlyst 15-mediated cyclodehydration of α-aryloxyketone.

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Chondroprotective and anti‐inflammatory effects of amurensin H by regulating TLR4/Syk/NF‐κB signals

Pei Ma, Lifeng Yue, Hui Yang, Yannan Fan et autres

The low-grade, chronic inflammation initiated by TLR4-triggered innate immune responses has a central role on early osteoarthritis. Amurensin H is a resveratrol dimer with anti-inflammatory and anti-apoptotic effects, while its effects on TLR-4 signals to inhibit osteoarthritis are still unclear. In the …

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Amurensin H, a Derivative From Resveratrol, Ameliorates Lipopolysaccharide/Cigarette Smoke–Induced Airway Inflammation by Blocking the Syk/NF-κB Pathway

Yannan Fan, Ziqian Zhang, Chun‐Suo Yao, Jinye Bai et autres

Amurensin H, a resveratrol dimer derived from Vitis amurensis Rupr, has several biological effects, including anti-inflammatory and anti-oxidant activities. Studies have found that amurensin H attenuated asthma-like allergic airway inflammation. However, its protective activity on COPD airway inflammation are not fully explored. …

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Versatile and Enantioselective Total Synthesis of Naturally Active Gnetulin

Changhui Shang, Yulong Kang, Qingyun Yang, Qibin Zhu et autres

Abstract A versatile and efficient enantioselective total synthesis of natural isorhapontigenin dimers (−)‐gnetulin, (+)‐gnetulin, and (±)‐gentulin was proposed. By using this method, we were able to synthesize the dimers from commercial available achiral materials in 13 steps, and achieve a 7%–9% overall …

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Facile, highly efficient and environmentally friendly transesterification mediated by platinum dioxide and nickel oxide under essentially neutral conditions

Binhao Teng, Jian‐Gong Shi, Chun‐Suo Yao

A practical, highly efficient and eco-friendly transesterification reaction under essentially neutral conditions was achieved using PtO 2 or PtO 2 /NiO as the catalyst.

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