Joshua M. Oakes

The Influence of a COVID-19 Vaccine Mandate on Vaccination Rates in a University Setting

Elisabeth Brandstetter, Bruno Bohn, Joshua M. Oakes, Ryan T. Demmer

We surveyed (September 9–17, 2021) students, staff, and faculty at the University of Minnesota, a large, highly vaccinated university, to evaluate whether the COVID-19 vaccine mandate increased self-reported vaccine uptake. Vaccine mandates have the potential to improve public health but should consider …

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Nicotine and novel tobacco products drive adverse cardiac remodeling and dysfunction in preclinical studies

Nicholas D. Fried, Joshua M. Oakes, Anna Whitehead, Eric D. Lazartigues et autres

Background: The heart undergoes structural and functional changes in response to injury and hemodynamic stress known as cardiac remodeling. Cardiac remodeling often decompensates causing dysfunction and heart failure (HF). Cardiac remodeling and dysfunction are significantly associated with cigarette smoking. Although cigarette smoking …

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Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway

Umadevi Subramanian, Chandramohan Ramasamy, Ramachandran Samivel, Joshua M. Oakes et autres

The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (Npr1) in mice provokes hypertension and cardiovascular dysfunction. The objective of this study was to determine the mechanisms regulating the development of cardiac fibrosis and dysfunction in Npr1 mutant mice. Npr1 …

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Examining perceived risk to bovine tuberculosis through factorial survey to inform policymaking for zoonotic diseases control and surveillance

Yuanyuan Wang, Joshua M. Oakes, Scott J. Wells

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Utilizing Cotinine Pharmacokinetics to Develop Protocols for Robust Cigarette Exposure Studies

Matthew Eden, Yasmeen M. Farra, Jacob Matz, Chiara Maria Bellini et autres

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Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice

Nicholas D. Fried, Tamara M. Morris, David C. Woods, Joshua M. Oakes et autres

Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases (CVPD), however, the role of nicotine in the pathogenesis of CVPD is incompletely understood. The purpose of this study was to examine the effects of …

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Chronic Nicotine Inhalation Promotes Differential Remodeling of the Right and Left Ventricles in Mice

Nicholas D. Fried, Tamara M. Morris, David C. Woods, Joshua M. Oakes et autres

Introduction Cigarette smoking continues to decline in the United States, but a rise in e‐cigarette use poses a threat to human health. E‐cigarettes, oft marketed as a healthier alternative to traditional forms of tobacco consumption, still contain nicotine. Cigarette smoking is a …

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Effects of Chronic Nicotine Inhalation on Systemic and Pulmonary Blood Pressure and Right Ventricular Remodeling in Mice

Joshua M. Oakes, Jiaxi Xu, Tamara M. Morris, Nicholas D. Fried et autres

Cigarette smoking is the single most important risk factor for the development of cardiovascular and pulmonary diseases; however, the role of nicotine in the pathogenesis of these diseases is incompletely understood. The purpose of this study was to examine the effects of …

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Abstract 046: Chronic Nicotine Inhalation Promotes the Development of Hypertension

Jiaxi Xu, Tamara M. Morris, Joshua M. Oakes, Jason D. Gardner et autres

While smoking is a proven risk factor for stroke and heart attacks, whether it contributes to the development of hypertension is still unclear. Nicotine inhalation is thought to activate the sympathetic nervous system and could contribute to the development of dysautonomia and …

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The Effects of Nicotine on Cardiac Function and Structure

Joshua M. Oakes, Joselyn Knowling, Eric D. Lazartigues, Xinping Yue et autres

Nicotine is the addictive chemical in tobacco‐related products, such as cigarettes, water pipes, e‐cigs, and chewing tobacco. While the effects of smoke from cigarettes and cigars are well known, the rise in popularity of smokeless electronic cigarettes (e‐cigs) brings new questions about …

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Blockade of Cardiac Hypertrophy and Fibrosis by TGF‐Beta 1 Receptor Antagonist in Npr1 Gene‐Knockout Mice

Ramachandran Samivel, Umadevi Subramanian, Joshua M. Oakes, Helene Chen et autres

Genetic disruption of guanylyl cyclase/natriuretic peptide receptor‐A (GC‐A/NPRA) gene ( Npr1 ) in mice triggers cardiac hypertrophy, fibrosis, and remodeling associated with heart failure. However, the specific mechanisms of cardiac defects in Npr1 null mutant mice is not well understood. The objective …

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Chronic Nicotine Inhalation Promotes the Development of Pulmonary Hypertension

Xinping Yue, Joshua M. Oakes, Jiaxi Xu, Eric D. Lazartigues et autres

Pulmonary hypertension is a condition of increased blood pressure within the arteries of the lungs, leading to clinical symptoms including shortness of breath, syncope, tiredness, chest pain, swelling of the legs, and a fast heartbeat. The exact cause of pulmonary hypertension is …

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