Anna Whitehead

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis

Anna Whitehead, Zhangjie Wang, Rebecca-Joe Boustany, Romain R. Vivès et autres

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Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet

Anna Whitehead, Zhen Li, Kyle B. LaPenna, Nour Abbes et autres

Nicotine product usage and high-fat diet consumption are two modifiable risk factors for cardiovascular diseases. Here, we demonstrate that in mice, combined exposure to inhaled nicotine and high-fat diet results in unique cardiovascular consequences compared with either treatment alone, including left ventricular …

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Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high fat diet

Anna Whitehead, Zhen Li, Kyle B. LaPenna, Thomas E. Sharp et autres

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and smoking remains the most significant preventable risk factor. The contribution of nicotine, the addictive component of all tobacco products, to smoking-related CVD remains poorly understood. In addition to smoking, obesity is …

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Role of Heparan Sulfate 6-O-Endosulfatases in Hematopoiesis

Anna Whitehead, Xinping Yue

Heparan sulfate proteoglycans (HSPGs) are expressed at the cell surface and in the extracellular matrix, including within the bone marrow microenvironment. Heparan sulfate (HS) is the glycosaminoglycan side chain of HSPGs, and these side chains bind to a myriad of growth factors, …

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Ovarian hormones do not mediate protection against pulmonary hypertension and right ventricular remodeling in female mice exposed to chronic, inhaled nicotine

Nicholas D. Fried, Anna Whitehead, Eric Lazartigues, Xinping Yue et autres

The emergence of electronic cigarettes poses a threat to cardiovascular and pulmonary health, but the direct contribution of nicotine to these disease processes is largely unknown. Our laboratory has previously shown that chronic, inhaled nicotine induces pulmonary hypertension and right ventricular remodeling …

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Nicotine and novel tobacco products drive adverse cardiac remodeling and dysfunction in preclinical studies

Nicholas D. Fried, Joshua M. Oakes, Anna Whitehead, Eric Lazartigues et autres

Background: The heart undergoes structural and functional changes in response to injury and hemodynamic stress known as cardiac remodeling. Cardiac remodeling often decompensates causing dysfunction and heart failure (HF). Cardiac remodeling and dysfunction are significantly associated with cigarette smoking. Although cigarette smoking …

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Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

Anna Whitehead, Nicholas D. Fried, Zhen Li, Kandasamy Neelamegam et autres

Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases; however, the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in mice leads to the development of pulmonary hypertension (PH) …

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Obesity exacerbates SARS‐CoV‐2 infection in K18‐hACE2 mice

Clara Berdasco, Anna Whitehead, Xuebin Qin, Xinping Yue et autres

Hypertension and obesity are considered risk factors for severe coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The aim of the current study was to examine whether hypertension and obesity alter SARS‐CoV‐2 infection, the development of …

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Myeloid Sulf Deletion and Immune Dysfunction in Multiple Sulfatase Deficiency

Anna Whitehead, Xinping Yue

Introduction Multiple sulfatase deficiency (MSD) is a rare autosomal recessive disease due to pathogenic mutations in the sulfatase‐modifying factor 1 ( SUMF1 ) gene. SUMF1 encodes the formylglycine‐generating enzyme responsible for an activating posttranslational modification of all sulfatases (17 in humans), and …

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Cardiopulmonary protection against nicotine‐induced pulmonary hypertension and right ventricular remodeling in mice is not mediated by ovarian hormones

Nicholas D. Fried, Anna Whitehead, Idanis Z. Garcia‐Sanchez, Eric Lazartigues et autres

Introduction Electronic cigarette use has increased globally prompting a joint committee of international cardiovascular research organizations to call for improved understanding of the health effects of nicotine. Our group has previously demonstrated that chronic, inhaled nicotine induces pulmonary hypertension (PH) and right …

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Sex-Dependent Effects of Inhaled Nicotine on the Gut Microbiome

Anna Whitehead, Margaret C Meyers, Christopher M. Taylor, Meng Luo et autres

INTRODUCTION: The impact of nicotine, the addictive component of both traditional cigarettes and e-cigarettes, on many physiological processes remains poorly understood. To date, there have been few investigations into the impact of nicotine on the gut microbiome, and these studies utilized oral …

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