Muhammed A. Saad

Neuroprotective effects of telmisartan in a harmaline-induced model of essential tremor: modulation of the renin-angiotensin system and inflammatory pathways

Sama M. Farrag, Amr M. Emam, Ahmed S. Kamel, Muhammed A. Saad et autres

Background: Essential tremor (ET) is a widespread neurological disorder with mild cerebellar degeneration that affects motor coordination, causing involuntary, rhythmic tremors during action. Excessive brain renin-angiotensin system activation favors pro-inflammatory milieu that is associated with neurodegenerative diseases. Objective: The present study aimed …

Égypte, ae (code pays fourni par la source)

Enhancing mood post-bariatric surgery: Associations of rosuvastatin with vitamin D, oxidative stress, and neurotransmitter-related outcomes in rats

Sally Atef Fahim, Muhammad Y. Al‐Shorbagy, Rabab Hamed Sayed, Albeir A. Messiha et autres

Bariatric surgery is effective for severe obesity, yet post-surgical depression poses challenges to weight loss outcomes. Beyond lipid-lowering, statins reduce diabetes recurrence and cardiac risks. Statin use has been linked with higher vitamin D levels, which decline after surgery. Rosuvastatin shows neuroprotective …

Égypte, ae, us (code pays fourni par la source)

The GLP-1 agonist semaglutide ameliorates cognitive regression in P301S tauopathy mice model via autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization

Norhan N. Elbadawy, Muhammed A. Saad, Sara Elfarrash, Maha A.E. Ahmed et autres

Égypte, ae (code pays fourni par la source)

Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus

Muhammed A. Saad, Alyasaa A. Rastanawi, Ayman E. El-Sahar, Alshaymaa Amin Zaki El-Bahy

ae, Égypte, sy, gb (code pays fourni par la source)

Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates

Naglaa F. El- Sayed, Marwa El‐Hussieny, Shaimaa T. Mansour, Marwa A. Fouad et autres

Égypte, ae (code pays fourni par la source)

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Aya Khaled, Esraa A. Ahmed, Mohamed Mamdouh, Hager Saad et autres

Hypertension is a serious concern as it is one of the causes of kideny failure and pulmonary fibrosis. An important therapeutic strategy for treating chronic hypertension is to inhibit the angiotensin converting enzyme (ACE). ACE inhibition reduces kidney damage, pulmonary artery pressure, …

Égypte, it, ae (code pays fourni par la source)

Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

Hany H. Arab, Ahmed H. Eid, Rania Yahia, Shuruq E. Alsufyani et autres

Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, its effect on cadmium neurotoxicity remains to be …

Égypte, sa, ae (code pays fourni par la source)

Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways

Hany H. Arab, Ebtehal Mohammad Fikry, Shuruq E. Alsufyani, Ahmed M. Ashour et autres

Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable antioxidant and anti-apoptotic features. It has shown marked cardio-, reno-, hepato-, and neuroprotective effects. Yet, its effect on Cd-evoked testicular impairment has …

Égypte, sa, ae (code pays fourni par la source)

Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway

Eman S. Zaki, Rabab Hamed Sayed, Muhammed A. Saad, Muhammed F. El-Yamany

Égypte, ae (code pays fourni par la source)

Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model

Ahmed Seif El Din Kamel, Sama M. Farrag, Heba Mohamed Mansour, Noha N. Nassar et autres

Background However, disturbances in cellular energy demarcate neuronal hyperexcitability in essential tremor (ET); nevertheless, no available data relates energy sensors and GABAergic neurotransmission in ET. Noteworthy, reports have asserted dapagliflozin’s (DAPA) role in enhancing autophagic sensors in other disorders. Herein, this study …

Égypte, ae (code pays fourni par la source)

Dulaglutide impedes depressive-like behavior persuaded by chronic social defeat stress model in male C57BL/6 mice: Implications on GLP-1R and cAMP/PKA signaling pathway in the hippocampus

Amal B. Darwish, Nesrine S. El Sayed, Abeer Salama, Muhammed A. Saad

lb, Égypte, ae (code pays fourni par la source)

Dulaglutide Impedes Depressive-Like Behavior Persuaded by Chronic Social Defeat Stress Model in Male C57BL/6 Mice: Implications on GLP-1R and cAMP/PKA Signaling Pathway in the Hippocampus

Amal Darwish, Muhammed A. Saad, Nesrine S. El Sayed, Abeer Salama

lb, Égypte (code pays fourni par la source)