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Profil bibliographique

Jennine M. Dawicki-McKenna

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

32Publications signalées
1364Citations signalées
1Affiliations récentes

Les institutions déclarées

Les domaines associés

Chromosomal and Genetic VariationsGenomics and Chromatin DynamicsMicrotubule and mitosis dynamicsRetinal Development and DisordersDNA Repair Mechanisms

Les publications récentes

Accès ouvert 2023 article OpenAlex

Centromere innovations within a mouse species

Craig W. Gambogi, Nootan Pandey, Jennine M. Dawicki-McKenna, Uma P. Arora et autres

Mammalian centromeres direct faithful genetic inheritance and are typically characterized by regions of highly repetitive and rapidly evolving DNA. We focused on a mouse species, Mus pahari, that we found has evolved to house centromere-specifying centromere protein-A (CENP-A) nucleosomes at the nexus …

us (code pays fourni par la source)

9 citations Science Advances
Accès ouvert 2023 article OpenAlex

The structural basis of the multi-step allosteric activation of Aurora B kinase

Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine M. Dawicki-McKenna et autres

Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how …

no, us (code pays fourni par la source)

14 citations eLife
Accès ouvert 2023 preprint OpenAlex

Centromere Innovations Within a Mouse Species

Craig W. Gambogi, Nootan Pandey, Jennine M. Dawicki-McKenna, Uma P. Arora et autres

Abstract Mammalian centromeres direct faithful genetic inheritance and are typically characterized by regions of highly repetitive and rapidly evolving DNA. We focused on a mouse species, Mus pahari, that we found has evolved to house centromere-specifying CENP-A nucleosomes at the nexus of …

us, ua (code pays fourni par la source)

1 citation bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2023 article OpenAlex

Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching

Jennine M. Dawicki-McKenna, Alex J. Félix, Elisa A. Waxman, Congsheng Cheng et autres

Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define the PTBP2 footprint in the human transcriptome using brain tissue and human …

us (code pays fourni par la source)

37 citations Nature Communications
Accès ouvert 2022 preprint OpenAlex

The structural basis of the multi-step allosteric activation of Aurora B kinase

Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine M. Dawicki-McKenna et autres

Abstract Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear …

no, us (code pays fourni par la source)

0 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2022 preprint OpenAlex

Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1

Jennine M. Dawicki-McKenna, Alex J. Félix, Elisa A. Waxman, Congsheng Cheng et autres

Abstract Alternative splicing of neuronal genes is controlled in part by the coordinated action of the polypyrimidine tract binding proteins (PTBP1 and PTBP2). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal, controlling the expression of such targets as DLG4 , which …

us (code pays fourni par la source)

0 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2021 article OpenAlex

Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

Catalina Salinas‐Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna et autres

Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is defined by a histone H3 variant, CENP-A. …

fr, us (code pays fourni par la source)

5 citations Cell Reports

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