Diego Josimar Hernández-Silva

Babesia bovis Enolase Is Expressed in Intracellular Merozoites and Contains B-Cell Epitopes That Induce Neutralizing Antibodies In Vitro

Alma Cárdenas-Flores, Minerva Camacho-Nuez, Massaro Wilson Ueti, Mario Hidalgo‐Ruiz et autres

Background: Bovine babesiosis, caused by the tick-borne apicomplexan parasite Babesia spp., is an economically significant disease that threatens the cattle industry worldwide. Babesia bovis is the most pathogenic species, leading to high morbidity and mortality in infected animals. One promising approach to …

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The Translationally Controlled Tumor Protein (TCTP), a Novel Antigen of Babesia bovis, Participates in the Establishment of Acute Infection and Contains Neutralizing B-Cell Epitopes

Chyntia Pérez-Almeida, Diego Josimar Hernández-Silva, Edwin Esaú Hernández-Arvizu, Masahito Asada et autres

Babesia bovis is a protozoan parasite that causes babesiosis in cattle. It has been hypothesized that in apicomplexan parasites, translationally controlled tumor protein (TCTP) interferes with the host immune response by inhibiting B cell proliferation. The aim of this study was the …

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Vaccines Against Ticks

Juan Mosqueda, Consuelo Almazán, Daniel Gustavo López-Díaz, Iván Corona-Guerrero et autres

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An Evaluation of the Cellular and Humoral Response of a Multi-Epitope Vaccine Candidate Against COVID-19 with Different Alum Adjuvants

L Rojas, Rocío Alejandra Ruiz‐Manzano, Miguel Andrés Velasco-Elizondo, María Antonieta Carbajo-Mata et autres

SARS-CoV-2 (Betacoronavirus pandemicum) is responsible for the disease identified by the World Health Organization (WHO) as COVID-19. We designed “CHIVAX 2.1”, a multi-epitope vaccine, containing ten immunogenic peptides with conserved B-cell and T-cell epitopes in the receceptor binding domain (RBD) sequences of …

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Detection of Bacteria with Potential to Cause Hospital-Associated Infections in a Small-Species Veterinary Hospital in Mexico

Diego Josimar Hernández-Silva, Ana Isabel Rivera-González, Laura Karina Avilés-Benítez, Mayra M. Becerra-Reyes et autres

Hospital-Associated Infections (HAIs) are caused by microorganisms that are not present before patients are admitted to healthcare facilities, and usually have multidrug resistance profiles. There is ample information and active research in human medicine to create preventive and control measures, but there …

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Evaluation of the humoral and mucosal immune response of a multiepitope vaccine against COVID-19 in pigs

Juan Mosqueda, Diego Josimar Hernández-Silva, Marco Antonio Vega‐López, Lineth Juliana Vega-Rojas et autres

Introduction This study evaluated the immune response to a multiepitope recombinant chimeric protein (CHIVAX) containing B- and T-cell epitopes of the SARS-CoV-2 spike’s receptor binding domain (RBD) in a translational porcine model for pre-clinical studies. Methods We generated a multiepitope recombinant protein …

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Spherical Body Protein 4 from Babesia bigemina: A Novel Gene That Contains Conserved B-Cell Epitopes and Induces Cross-Reactive Neutralizing Antibodies in Babesia ovata

Juan Mosqueda, Diego Josimar Hernández-Silva, Massaro Wilson Ueti, Adolfo Cruz-Reséndiz et autres

Bovine babesiosis is a tick-transmitted disease caused by intraerythrocytic protozoan parasites of the genus Babesia. Its main causative agents in the Americas are Babesia bigemina and Babesia bovis, while Babesia ovata affects cattle in Asia. All Babesia species secrete proteins stored in …

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Thrombospondin-Related Anonymous Protein (TRAP) Family Expression by Babesia bovis Life Stages within the Mammalian Host and Tick Vector

Hayley E. Masterson, Naomi S. Taus, Wendell C. Johnson, Lowell S. Kappmeyer et autres

The tick-transmitted disease bovine babesiosis causes significant economic losses in many countries around the world. Current control methods include modified live-attenuated vaccines that have limited efficacy. Recombinant proteins could provide effective, safe, and low-cost alternative vaccines. We compared the expression of the …

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Innovative recombinant protein-based vaccines against SARS-CoV-2

Juan Mosqueda, Diego Josimar Hernández-Silva, Andrea Romero‐Maldonado, Susana Mejia-López et autres

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List of contributors

Ana C. Alcalá, C. Almendarez-Rodríguez, J.M. Alvarado-Orozco, Julio Y. Anaya-Covarrubias et autres

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Vaccine efficacy of recombinant BmVDAC on Rhipicephalus microplus fed on Babesia bigemina-infected and uninfected cattle

Reyna Ortega-Sánchez, Minerva Camacho-Nuez, Elizabeth Jacqueline Castañeda-Ortiz, Máximo Martínez-Benitez et autres

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Análisis de la variabilidad alélica de BmVDAC y Subolesina, dos candidatos vacunales contra Rhipicephalus microplus en aislados de México

María Martina Esperanza Pérez-Soria, Diego Josimar Hernández-Silva, Juan Mosqueda

Introducción: Las garrapatas Rhipicephalus microplus son ectoparásitos hematófagos que impactan económicamente la ganadería a nivel mundial. Los acaricidas han sido una estrategia de control efectiva pero que generan la resistencia a estos químicos y la contaminación del medio ambiente. Una alternativa para …

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