Laura K. Becker

Mapping the evolution of the forced swim test across interpretation, welfare and pharmacology

Christiane Brandwein, Cathalijn H. C. Leenaars, Ana-Maria Iorgu, Laura K. Becker et autres

The Porsolt Forced Swim Test (FST), primarily utilized for phenotyping and screening novel antidepressants in rodents, is one of the most widely used tests in depression research. Despite its popularity, this test has received increasing criticism mainly due to welfare concerns and …

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Real-World Dosing Patterns of Biologics for the Treatment of Hidradenitis Suppurativa

Pelin Ozluk, Benjamin J. Chastek, Laura K. Becker, Chike Okoro et autres

Biomarker Testing Approaches, Treatment Selection, and Cost of Care Among Adults With Advanced Cancer

Stacey DaCosta Byfield, Bela Bapat, Laura K. Becker, Carolina Reyes et autres

Importance: Clinical guidelines recommend biomarker testing to identify patients eligible for targeted therapy. However, evidence suggests that biomarker testing rates are below guideline recommendations, which has been associated with worsened clinical outcomes, including overall survival. Objectives: To identify patients with newly diagnosed …

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HPR84 Trends in Respiratory Pathogen Testing With Individual Pathogen, Small Panel, or Large Panel Polymerase Chain Reaction (PCR) Tests Before and After the Coronavirus Disease 2019 (COVID-19) Public Health Emergency (PHE) Ended

Karen M. Stockl, Laura K. Becker, Jamie M. Tucker

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RWD15 Characteristics of Patients With Minimal Residual Disease (MRD) Testing for Solid Tumors in a United States Population With Commercial or Medicare Advantage (MA) Insurance

Karen M. Stockl, Pamela E. Morin, Laura K. Becker, Laura Simmer et autres

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Abstract RF1-06: Association of polygenic-based breast cancer risk prediction with patient management

Katie Johansen Taber, Sarah Ratzel, Elisha Hughes, Alexander Gutin et autres

Abstract Background:A breast cancer (BC) risk predictor that combines the Tyrer-Cuzick (TC) risk model with a polygenic risk score (“combined risk score” or CRS) has been shown to significantly improve risk prediction over TC alone. Guidelines recommend that individuals predicted to have …

Minimal residual disease (MRD) test utilization in the first 6 months after initiating MRD testing in patients with colorectal cancer (CRC).

Stacey DaCosta Byfield, Karen M. Stockl, Pamela E. Morin, Laura K. Becker et autres

e15710 Background: With high levels of postoperative circulating tumor DNA (ctDNA) identified as a potential predictor of CRC recurrence, clinical studies are ongoing to obtain evidence to support using ctDNA results to determine risk features for consideration of adjuvant therapy in stage …

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Association of Polygenic-Based Breast Cancer Risk Prediction With Patient Management

Katherine Johansen Taber, Elisha Hughes, Alexander Gutin, William Brady DeHart et autres

PURPOSE Breast cancer (BC) risk prediction is more accurate when clinical and polygenic factors are combined (combined risk score [CRS]), but little is known about how CRS results affect real-world patient management. METHODS Deidentified medical and pharmacy claims data were linked with …

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Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes in a claims-based cohort

Elham Afghani, Bryan M. Lau, Laura K. Becker, Michael Goggins et autres

OBJECTIVE: Pancreatic cancer diagnoses are frequently preceded by a new diabetes diagnosis. Screening individuals newly diagnosed with diabetes could enable the earlier detection of pancreatic cancer. We sought to estimate the risk of pancreatic cancer by age, sex, race and time since …

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Reference values for static posturography of sportive and healthy adults aged 18–30 years

Stephan Thomas Becker, Anna Thomas, Lilli Ulrich, Laura K. Becker et autres

BACKGROUND: Measuring postural sway and comparing results in a pre-post design or with reference values can increase diagnostic accuracy and the quality of certain treatments and rehabilitation. The process of continuously regulating and sustaining a stable posture involves intricate sensorimotor control. METHODS: …

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Real-World Impact of Pharmacogenomic Testing on Medication Use and Healthcare Resource Utilization in Patients With Major Depressive Disorder

Andria Lee Del Tredici, Holly L. Johnson, Brady DeHart, Alexander Gutin et autres

BACKGROUND: Pharmacogenomic (PGx) testing can help improve response and remission rates for patients with major depressive disorder (MDD) and at least one treatment failure. To investigate real-world outcomes, we examined 1) significant gene-drug interactions (GDIs) and 2) healthcare resource utilization (HRU) in …

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Impact of race, sex and age on the probability of pancreatic cancer among patients with newly diagnosed diabetes

Elham Afghani, Bryan M. Lau, Laura K. Becker, Michael Goggins et autres

ABSTRACT Background Pancreatic cancer diagnoses are frequently preceded by a new diabetes diagnosis. Screening individuals newly diagnosed with diabetes could enable earlier pancreatic cancer detection. We sought to estimate the risk of pancreatic cancer by age, sex, race and time since diabetes …

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