Burkhard Hirsch

Corrigendum to ‘Resistance of Cutaneous Anaplastic Large-Cell Lymphoma Cells to Apoptosis by Death Ligands Is Enhanced by CD30-Mediated Overexpression of c-FLIP’

Frank Braun, Burkhard Hirsch, Nadya Al‐Yacoub, Horst Dürkop et autres

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A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

Steffen Hennig, Kristin Gennermann, Sefer Elezkurtaj, Volkhard Seitz et autres

Abstract Tumor-specific T-cells are key in combating cancer as shown in adoptive cell therapy with tumor infiltrating lymphocytes (TILs) and checkpoint inhibitor therapy. Studies in many types of cancer have shown that preexisting tumor reactive T-cells are not only tumor-but typically also …

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Integrative genomic analysis focused on cell cycle genes for MYC-driven aggressive mature B-cell lymphoma

Takahisa Yamashita, Claudia Vollbrecht, Burkhard Hirsch, Karsten Kleo et autres

MYC is a transcriptional factor that regulates growth and proliferation through cell cycle pathways. MYC alterations, in particular MYC rearrangements, are important in assessing the prognosis of aggressive B-cell lymphoma. In this study, we focused on the impact of nine major cell …

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Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics

Burkhard Hirsch, Volker Endris, Silke Laßmann, Wilko Weichert et autres

The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based targeted next-generation sequencing (NGS). However, only few studies are available comparing multicenter testing of different NGS platforms and gene panels. …

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Antibody-based delivery of tumor necrosis factor (L19-TNFα) and interleukin-2 (L19-IL2) to tumor-associated blood vessels has potent immunological and anticancer activity in the syngeneic J558L BALB/c myeloma model

Hans Dietrich Menssen, Ulf Harnack, Ulrike Erben, Dario Neri et autres

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A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B‐cell lymphoma

Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt et autres

Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or relapsed B-cell lymphoma achieved partial or complete remissions. Therefore, the purpose of …

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Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

Claudia Vollbrecht, Robert A. Werner, Robert F. H. Walter, Daniel Christian Christoph et autres

BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide. The typical and atypical carcinoid (TC and AC), the large-cell neuroendocrine carcinoma (LCNEC) and the small-cell lung cancers (SCLC) are subgroups of pulmonary tumours that show neuroendocrine differentiations. With the rising …

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Induction of the inflammatory regulator A 20 by gibberellic acid in airway epithelial cells

James A Reihill, B Malcomson, Anne Kjørsvik Bertelsen, Sarah K. C. Cheung et autres

BACKGROUND AND PURPOSE: NF-κB-driven inflammation is negatively regulated by the zinc finger protein A20. Gibberellic acid (GA3 ) is a plant-derived diterpenoid with documented anti-inflammatory activity, which is reported to induce A20-like zinc finger proteins in plants. Here, we sought to investigate …

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Abundant in vitro expression of the oncofetal ED-B-containing fibronectin translates into selective pharmacodelivery of 131I-L19SIP in a prostate cancer patient

Ricarda Johanna Locher, Paola Anna Erba, Burkhard Hirsch, Emilio Bombardieri et autres

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Defective A20 signalling in CF: Anti-inflammatory action of gibberellins

Catriona Kelly, James A Reihill, Beth Malconsom, Agnieszka Czerwiec et autres

Introduction: A20 negatively regulates NF-κB signalling and is induced in response to bacteria or viruses. Recently, we reported significant reductions in the expression/function of A20 in the CF airway epithelium (Kelly et al. ERJ 2012). The plant diterpene Gibberellin (GA) induces A20-like …

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RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells

Burkhard Hirsch, Edda von der Wall, Michael Hummel, Horst Dürkop

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A novel A20 (TNFAIP3) antibody (Ber‐A20) can be used to detect unmutated A20 by immunohistology

Burkhard Hirsch, Maria Grünbaum, Florian Wagner, Yingwen Bi et autres

AIMS: A20 (TNFAIP3) is a nuclear factor-κB (NF-κB)-inducible component of tumour necrosis factor and Toll-like receptor intracellular signal transduction. It negatively regulates NF-κB, and has been identified as a tumour suppressor. Several studies have described A20 inactivation by deletion of the A20 …

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