Maria Geropeppa

Systems analysis of immunity to pneumococcal vaccination in preterm and full term infants

Maria Geropeppa, Ioanna Papadatou, Kleio‐Maria Verrou, Peter Lembessis et autres

BACKGROUND: Preterm infants mount lower humoral responses to the 13-valent pneumococcal conjugate vaccine (PCV13) than full-term infants; however, the long-term impact of prematurity on vaccine-induced protection remains unclear. This study investigates the innate and adaptive immune responses to a 3+1 PCV13 schedule …

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Systemic Corticosteroids in Children With Pneumonia: Α Systematic Review and Meta-analysis

Maria Geropeppa, Panagiota Tsagkli, Ioanna Papadatou, Vasiliki Efthymiou et autres

BACKGROUND: Corticosteroids are effective adjunct treatment for certain infectious diseases. However, their role in children with community-acquired pneumonia (CAP) remains unclear. We aim to assess the efficacy and safety of adjunct corticosteroid therapy in pediatric CAP. MATERIALS AND METHODS: A systematic literature …

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Hybrid Immunity against SARS-CoV-2 Variants: A Narrative Review of the Literature

Panagiota Tsagkli, Maria Geropeppa, Ioanna Papadatou, Vana Spoulou

The emergence of SARS-CoV-2 led to a global health crisis and the burden of the disease continues to persist. The rapid development and emergency authorization of various vaccines, including mRNA-based vaccines, played a pivotal role in mitigating severe illness and mortality. However, …

Deciphering Immune Responses to Immunization via Transcriptional Analysis: A Narrative Review of the Current Evidence towards Personalized Vaccination Strategies

Ioanna Papadatou, Maria Geropeppa, Christina Piperi, Vana Spoulou et autres

The development of vaccines has drastically reduced the mortality and morbidity of several diseases. Despite the great success of vaccines, the immunological processes involved in protective immunity are not fully understood and several issues remain to be elucidated. Recently, the advent of …

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Receptor-Binding-Domain-Specific B Cell Responses Induced by mRNA Immunization against SARS-CoV-2

Maria Geropeppa, Ioanna Papadatou, Panagiotis Sarantis, Marianna Tzanoudaki et autres

mRNA vaccines have been instrumental in controlling the SARS-CoV-2 pandemic, but the short-lived protection mediated by Receptor Binding Domain (RBD)-specific antibodies necessitates frequent revaccinations to enhance vaccine-induced immunity. The development of RBD-specific B cell memory is critical for improving the qualitative and …

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SARS-CoV-2 mRNA Dual Immunization Induces Innate Transcriptional Signatures, Establishes T-Cell Memory and Coordinates the Recall Response

Ioanna Papadatou, Maria Geropeppa, Kleio‐Maria Verrou, Marianna Tzanoudaki et autres

BACKGROUND: mRNA vaccines have played a crucial role in controlling the SARS-CoV-2 global pandemic. However, the immunological mechanisms involved in the induction, magnitude and longevity of mRNA-vaccine-induced protective immunity are still unclear. METHODS: In our study, we used whole-RNA sequencing along with …

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Protecting the Offspring, the Gift of Maternal Immunization: Current Status and Future Perspectives

Theano Lagousi, Despοina Gkentzi, Maria Geropeppa, Panagiota Tsagkli et autres

Pregnancy is characterized by immunological alterations in pregnant women that permit the growth of a semi-allogenic fetus, resulting in greater susceptibility of childbearing women to infections. Furthermore, due to the immaturity of the immune system of neonates, a protection gap is present …

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Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection

Theano Lagousi, John G. Routsias, Maria Mavrouli, Ioanna Papadatou et autres

Humoral immunity after SARS-CoV-2 immunization or natural infection is thought to be evanescent. In our study, we aimed to longitudinally characterize the kinetics of antibody titers after dual BNT162b2 immunization or wild-type infection. Vaccinated and recovered individuals displayed distinct antibody kinetics, as …

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The first women physicians in the history of modern Greek medicine

Maria Geropeppa, Dimitris Altis, Nikos Dedes, Marianna Karamanou

In an era when medicine in Greece was dominated by men, at the end of the 19th and during the first decades of 20th century, two women, Maria Kalapothakes [in Greek: Μαρία Καλαποθάκη] (1859-1941) and Angélique Panayotatou [in Greek: Αγγελική Παναγιωτάτου] (1878-1954), …

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Late-onset cardiomyopathy among survivors of childhood lymphoma treated with anthracyclines: a systematic review

Despoina-Rafailia Benetou, E Stergianos, Maria Geropeppa, Erato Ntinopoulou et autres

Medical advances in pediatric oncology have led to increases in survival but the long-term adverse effects of treatment in childhood cancer survivors have not yet been examined in depth. In this systematic review, we aimed to study the prevalence and risk factors …

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