Ioanna Papadatou

Systems analysis of immunity to pneumococcal vaccination in preterm and full term infants

Maria Geropeppa, Ioanna Papadatou, Kleio‐Maria Verrou, Peter Lembessis et autres

BACKGROUND: Preterm infants mount lower humoral responses to the 13-valent pneumococcal conjugate vaccine (PCV13) than full-term infants; however, the long-term impact of prematurity on vaccine-induced protection remains unclear. This study investigates the innate and adaptive immune responses to a 3+1 PCV13 schedule …

gr, nl (code pays fourni par la source)

Systemic Corticosteroids in Children With Pneumonia: Α Systematic Review and Meta-analysis

Maria Geropeppa, Panagiota Tsagkli, Ioanna Papadatou, Vasiliki Efthymiou et autres

BACKGROUND: Corticosteroids are effective adjunct treatment for certain infectious diseases. However, their role in children with community-acquired pneumonia (CAP) remains unclear. We aim to assess the efficacy and safety of adjunct corticosteroid therapy in pediatric CAP. MATERIALS AND METHODS: A systematic literature …

gr, fr, es (code pays fourni par la source)

Advances in Biotechnology and the Development of Novel Human Vaccines

Ioanna Papadatou, Athanasios Michos

Recent advances in biotechnology have fundamentally reshaped the landscape of vaccine development, offering innovative strategies to improve immunogenicity, safety and accessibility. This review explores the cutting-edge platforms-including mRNA, DNA, virus-like particles, viral and bacterial vectors, and bacteriophage-based vaccines-that are redefining how vaccine …

gr (code pays fourni par la source)

Targeting epigenetic mechanisms of resistance to chemotherapy in gliomas

Panagiotis Skouras, Mariam Markouli, Ioanna Papadatou, Christina Piperi

gr, us (code pays fourni par la source)

Hybrid Immunity against SARS-CoV-2 Variants: A Narrative Review of the Literature

Panagiota Tsagkli, Maria Geropeppa, Ioanna Papadatou, Vana Spoulou

The emergence of SARS-CoV-2 led to a global health crisis and the burden of the disease continues to persist. The rapid development and emergency authorization of various vaccines, including mRNA-based vaccines, played a pivotal role in mitigating severe illness and mortality. However, …

The Divergent Effect of Different Infant Vaccination Schedules of the 13-Valent Pneumococcal Conjugate Vaccine on Serotype-Specific Immunological Memory

Irene Tzovara, Ioanna Papadatou, Marianna Tzanoudaki, Christina Piperi et autres

Pneumococcal vaccination schedules are traditionally assessed based on the antibody response. The Memory B Cell (MBC) response has been less studied, despite its role in the magnitude and longevity of protection. We compared the immune response to different vaccination schedules with the …

gr (code pays fourni par la source)

Deciphering Immune Responses to Immunization via Transcriptional Analysis: A Narrative Review of the Current Evidence towards Personalized Vaccination Strategies

Ioanna Papadatou, Maria Geropeppa, Christina Piperi, Vana Spoulou et autres

The development of vaccines has drastically reduced the mortality and morbidity of several diseases. Despite the great success of vaccines, the immunological processes involved in protective immunity are not fully understood and several issues remain to be elucidated. Recently, the advent of …

gr, us (code pays fourni par la source)

Immunogenicity, Immunological Memory and Monitoring of Disease Activity Following an Anamnestic Immunization With the 13-Valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome

Κωνσταντίνα Κίτσου, Varvara Askiti, Marianna Tzanoudaki, Andromachi Mitsioni et autres

Anamnestic 13-valent pneumococcal conjugate vaccine immunization did not affect the relapse risk in pediatric idiopathic nephrotic syndrome. Pneumococcal serotype (PS)-specific antibody titers increased significantly in all groups. Children receiving immunomodulatory treatments (IMTs) displayed significantly lower levels of PS-specific antibodies for 3/8 serotypes …

gr (code pays fourni par la source)

Receptor-Binding-Domain-Specific B Cell Responses Induced by mRNA Immunization against SARS-CoV-2

Maria Geropeppa, Ioanna Papadatou, Panagiotis Sarantis, Marianna Tzanoudaki et autres

mRNA vaccines have been instrumental in controlling the SARS-CoV-2 pandemic, but the short-lived protection mediated by Receptor Binding Domain (RBD)-specific antibodies necessitates frequent revaccinations to enhance vaccine-induced immunity. The development of RBD-specific B cell memory is critical for improving the qualitative and …

gr (code pays fourni par la source)

Intrafamilial Transmission of Pneumococcal Acute Spontaneous Peritonitis

Ioanna Papadatou, Angeliki Moudaki, Anastasia Mentessidou, D. Tsakogiannis et autres

, Pneumococcus) is a major cause of childhood morbidity and mortality worldwide. The most common presentations of invasive pneumococcal disease (IPD) in children include bacteremic pneumonia, meningitis, and septicemia. However, pneumococcal acute spontaneous peritonitis is a highly uncommon-and potentially life-threatening-presentation of invasive …

gr (code pays fourni par la source)

SARS-CoV-2 mRNA Dual Immunization Induces Innate Transcriptional Signatures, Establishes T-Cell Memory and Coordinates the Recall Response

Ioanna Papadatou, Maria Geropeppa, Kleio‐Maria Verrou, Marianna Tzanoudaki et autres

BACKGROUND: mRNA vaccines have played a crucial role in controlling the SARS-CoV-2 global pandemic. However, the immunological mechanisms involved in the induction, magnitude and longevity of mRNA-vaccine-induced protective immunity are still unclear. METHODS: In our study, we used whole-RNA sequencing along with …

gr (code pays fourni par la source)

Comparative Characterization of Human Antibody Response Induced by BNT162b2 Vaccination vs. SARS-CoV-2 Wild-Type Infection

Theano Lagousi, John G. Routsias, Maria Mavrouli, Ioanna Papadatou et autres

Humoral immunity after SARS-CoV-2 immunization or natural infection is thought to be evanescent. In our study, we aimed to longitudinally characterize the kinetics of antibody titers after dual BNT162b2 immunization or wild-type infection. Vaccinated and recovered individuals displayed distinct antibody kinetics, as …

gr (code pays fourni par la source)