Accès ouvert
2024
article
OpenAlex
Elena Morandi, Véronique Adoue, I Bernard, Ekaterina Friebel et autres
BACKGROUND AND OBJECTIVES: gene, which results in a glycine-to-serine substitution at position 307 of the CD226 protein, has been implicated as a risk factor of various immune-mediated diseases, including multiple sclerosis (MS). Compelling evidence suggests that this allele may play a significant …
fr
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Accès ouvert
2024
article
OpenAlex
I Bernard, Doris G. Ransy, Jason C. Brophy, Fatima Kakkar et autres
OBJECTIVE: To investigate the association between African ancestry and neutrophil counts among children living with HIV (CLWH). We also examined whether medications, clinical conditions, hospitalization, or HIV virologic control were associated with low neutrophil counts or African ancestry. DESIGN: We conducted a …
ca
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Accès ouvert
2024
article
OpenAlex
Rémi Marrocco, I Bernard, Emeline Joulia, Rébecca Barascud et autres
Abstract The susceptibility to autoimmune diseases is conditioned by the association of modest genetic alterations which altogether weaken self-tolerance. The mechanism whereby these genetic interactions modulate T-cell pathogenicity remains largely uncovered. Here, we investigated the epistatic interaction of two interacting proteins involved …
fr, us
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Accès ouvert
2024
article
OpenAlex
Saniya Kari, Florence Bucciarelli, Thibault Angles, Oster Anne-Cécile et autres
BACKGROUND: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown. OBJECTIVE: To …
fr
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Accès ouvert
2022
article
OpenAlex
I Bernard, Doris G. Ransy, Jason C. Brophy, Fatima Kakkar et autres
Perinatally infected children living with HIV (CLWH) face lifelong infection and associated inflammatory injury. Chitinase-like 3 protein-1 (CHI3L1) is expressed by activated neutrophils and may be a clinically informative marker of systemic inflammation in CLWH. We conducted a multi-centre, cross-sectional study of …
ca
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Accès ouvert
2020
article
OpenAlex
I Bernard, Daniel Limonta, Lara K. Mahal, Tom C. Hobman
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public health. Although primarily a respiratory illness, extrapulmonary manifestations of COVID-19 include gastrointestinal, cardiovascular, renal and neurological diseases. Recent studies suggest …
ca
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Accès ouvert
2019
article
OpenAlex
Jason P. Fernandes, Francisca Cristi, Heather E. Eaton, Patricia A. Chen et autres
We demonstrate that metalloproteases in breast tumor microenvironments can inactivate reovirus. Our findings expose that tumor microenvironment proteases could have a negative impact on proteinaceous cancer therapies, such as reovirus, and that modification of such therapies to circumvent inactivation by tumor metalloproteases …
ca
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Accès ouvert
2019
preprint
OpenAlex
Jason P. Fernandes, Francisca Cristi, Heather E. Eaton, Patricia A. Chen et autres
ABSTRACT Reovirus is undergoing clinical testing as an oncolytic therapy for breast cancer. Given that reovirus naturally evolved to thrive in enteric environments, we sought to better understand how breast tumor microenvironments impinge on reovirus infection. Reovirus was treated with extracellular extracts …
ca
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
I Bernard, Antoine Sacquin, Sahar Kassem, Mehdi Benamar et autres
The guanine nucleotide exchange factor Vav1 is essential for transducing T cell receptor (TCR) signals and plays an important role in T cell development and activation. Previous genetic studies identified a natural variant of Vav1 characterized by the substitution of an arginine …
fr
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2018
article
OpenAlex
Guillaume Gaud, Romain Roncagalli, Karima Chaoui, I Bernard et autres
T cells. Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production. Thus, our study reveals that a VAV1-based, synergistic cross-talk exists between the TCR and CD226 during …
fr
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Accès ouvert
2017
article
OpenAlex
Thomas Sécher, Sahar Kassem, Mehdi Benamar, I Bernard et autres
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with an increasing incidence in developed countries. Recent reports suggest that modulation of the gut microbiota might be one promising therapy for MS. Here, we investigated whether the …
fr
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Accès ouvert
2017
article
OpenAlex
Fanny Duguet, Marie Locard‐Paulet, Marlène Marcellin, Karima Chaoui et autres
Regulatory T cells (Treg) represent a minor subpopulation of T lymphocytes that is crucial for the maintenance of immune homeostasis. Here, we present a large-scale quantitative mass spectrometry study that defines a specific proteomic "signature" of Treg. Treg and conventional T lymphocyte …
fr
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