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2024
article
Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk
Nasim Mavaddat, Minouk J. Schoemaker, Hiltrud Brauch, Thomas Brüning, David J. Hunter, Montserrat García‐Closas, Jose E. Castelao, Eunjung Lee, Mikael Eriksson, Xiaohong R. Yang, N. Chatterjee, Kamila Czene, Paul D.P. Pharoah, Andrew Wilcox, Stig E. Bojesen, A. Jung, Cari M. Kitahara, Daniele Campa, Robert J. MacInnis, Pabitra Pal Choudhury, Q. Wang, I.L. Andrulis, Walter C. Willett, Marike Gabrielson, Guillermo Pita, Ben Schöttker, Esther M. John, Trevor Ahearn, Michael E. Jones, Martha S. Linet, Christine L. Clarke, Ross L. Prentice, Kathryn J. Ruddy, Alicia Beeghly‐Fadiel, P.A. Fasching, Yon‐Dschun Ko, Federico Canzian, S.L. Neuhausen, Volker Arndt, Lin Fritschi, John J. Spinelli, Manuela Gago-Domínguez, Mia M. Gaudet, R. Kaaks, Per Hall, Rodney J. Scott, Jane Heyworth, Anna González‐Neira, Elke M. van Veen, J. Benitez, Manjeet K. Bolla, S. M. Gapstur, Paul L. Auer, Joe Dennis, Diether Lambrechts, Melissa C. Southey, Jennifer Stone, Angela Cox, Heiko Becher, Arif B. Ekici, Stacey J. Winham, Zumuruda Abu-Ful, U. Hamann, Xiao‐Ou Shu, Jolanta Lissowska, B. Holleczek, kConFab AOCS Investigators, Robert N. Hoover, Anthony Howell, Laura E. Beane Freeman, Allison W. Kurian, L. Le Marchand, Alicja Wolk, Simon S. Cross, C. Saunders, Alison M. Dunning, William G. Newman, X. Wang, Renske Keeman, Peter Kraft, Qiuyin Cai, Ana Llaneza, Caroline Weltens, Ãngel Carracedo, Niclas Håkansson, ABCTB Investigators, John L. Hopper, Jiayu Dai, Ann Smeets, Georgia Chenevix‐Trench, Pascal Guénel, Sara Lindström, Hedy S. Rennert, Argyrios Ziogas, Marı́a Elena Martı́nez, Melissa A. Troester, Clarice R. Weinberg, Aaron D. Norman, D. Gareth Evans, Andrew F. Olshan, Eric C. Polley, D.F. Easton, H. Anton-Culver, Catriona McLean, Brad Carter, Jonine D. Figueroa, G. Rennert, H.S. Earp, Nick Orr, Lothar Haeberle, Sigrid Hatse, Roger L. Milne, Sabine Behrens, Jack A. Taylor, Celine M. Vachon, Chi Gao, Kyriaki Michailidou, Janet E. Olson, Graham G. Giles, F. Lejbkowicz, Håkan Olsson, Fredrick R. Schumacher, Rulla M. Tamimi, C.M. Perou, C.A. Haiman, L. Bernstein, Hermann Brenner, Dale P. Sandler, S.J. Chanock, Anthony J. Swerdlow, F.J. Couch, Christopher G. Scott, Marina Beckmann, A. Heather Eliassen, Stella Koutros, Katie M. O’Brien, Jenny Chang‐Claude, Kristan J. Aronson, Wei Zheng, Taylor Maurer, Marjanka K. Schmidt
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Rattachement africain : us.
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Le résumé fourni par la source
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.
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Les sujets associés
Nutrition, Genetics, and DiseaseCancer Risks and Factors