Juan Luis Lopez-Canovas

Postbiotics Against Breast Cancer: A Narrative Review Bridging Preclinical Evidence with Potential Clinical Application

Chiara Luongo, Roberta Di Santillo, Alessia Cadavere, Franca Oglio et autres

Breast cancer is the most common cancer in women, causing more than 600,000 deaths every year. The human microbiome is increasingly recognized as a key regulator of cancer initiation, progression, and therapeutic response. Postbiotics-defined as non-viable microbial cells and/or their structural components …

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EP425 - ECE_2237 - Molecular and functional characterization of aminoacyl-tRNA synthetases in hepatocellular carcinoma

María Serrano-Jiménez, Natalia Hermán-Sánchez, Belén Gracia-Herencia, Manuel Rodríguez‐Perálvarez et autres

Abstract Introduction Nutrient availability and amino acid homeostasis are central regulators of metabolic and endocrine function in the liver. Alterations in amino acid sensing and utilization contribute to metabolic reprogramming in metabolic dysfunction–associated steatotic liver disease (MASLD), a major driver of liver-related …

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EP909 - ECE_2236 - RNA-exosome dysregulation: core and PAXT complexes as novel mediators of MASLD-HCC oncogenesis

Maria Isabel Pozo-Relano, Victor J. Fernandez-Ramirez, Samanta Lozano de la Haba, Manuel Rodríguez‐Perálvarez et autres

Abstract Metabolic-associated steatotic liver disease (MASLD) has emerged as the primary chronic liver dysfunction worldwide, frequently culminating in the development of hepatocellular carcinoma (HCC). Emerging evidence underscores the critical importance of RNA metabolism and surveillance in liver pathophysiology, where the RNA-Exosome complex …

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EP1077 - ECE_2070 - Novel insights on the role of putative neuronostatin receptor GPR107 in liver pathophysiology

Antonio Garcia-Estrada, Betsaida Ojeda-Pérez, Amelie Lupp, Stefan Schulz et autres

Abstract Our understanding of the somatostatin (SST) endocrine system, which is a well-established source of biomarkers and therapeutic targets in neuroendocrine and pituitary tumours, has been lately expanded through the discovery of neuronostatin (NST), a SST-alternative peptide; the identification of its putative …

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WED-261 Exploring hepatocellular carcinoma through a neuroendocrine lens: the somatostatin system as an intricate source of tumour evaluation strategies and therapeutic vulnerabilities

Antonio Garcia-Estrada, Betsaida Ojeda-Perez, Maria Isabel Pozo-Relano, Maria Serrano-Jimenez et autres

Aspartyl-tRNA synthetase 1 (DARS1) reshapes hepatocellular carcinoma proteome and promotes aggressiveness through noncanonical SAGA–MYC signaling modulation

Natalia Hermán-Sánchez, Maite G. Fernández-Barrena, Paloma Elma Alañón-Martínez, Iker Uriarte et autres

BACKGROUND AND AIMS: Aminoacyl-tRNA synthetases (ARSs) exert canonical and emerging noncanonical roles in cancer. Given the frequent alterations in aspartate metabolism in HCC, we investigated the clinical and functional significance of aspartyl-tRNA synthetase (DARS1) in HCC. APPROACH AND RESULTS: DARS1 expression was …

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17 - LA MAQUINARIA DEL ARN-EXOSOMA SE ENCUENTRA DESREGULADA EN CARCINOMA HEPATOCELULAR: RELEVANCIA FUNCIONAL DE LOS COMPLEJOS CORE Y PAXT

Maria Isabel Pozo-Relano, Victor J. Fernandez-Ramirez, Samanta Lozano-de la Haba, Belén Gracia-Herencia et autres

V-3 - DARS1 INCREMENTA LA AGRESIVIDAD DEL CARCINOMA HEPATOCELULAR MEDIANTE FUNCIONES CANÓNICAS Y NO CANÓNICAS MEDIADAS POR SAGA-MYC

Natalia Hermán-Sánchez, Maite G Fernandez-Barrena, Paloma Elma Alañón-Martínez, Iker Uriarte et autres

V-4 - ALTERACIÓN PROTEÓMICA DE LOS REGULADORES DEL SPLICING EN CARCINOMA HEPATOCELULAR: PAPEL FUNCIONAL Y POTENCIAL TERAPÉUTICO DE LSM2

Juan Luis Lopez-Canovas, Natalia Hermán-Sánchez, Victor J. Fernandez-Ramirez, Rubén Ciria et autres

Metformin improves hepatic steatosis in diet induced obese FVB/N mice: Alterations of glucose metabolism and hepatic splicing machinery

André Sarmento-Cabral, Emilia Alors‐Pérez, Marina Sánchez‐Frías, Antonio C. Fuentes-Fayos et autres

Metformin can reduce body weight gain and hepatic fat accumulation induced by a high-fat diet (HFD). However, the results obtained in animal models regarding metformin's role in modulating other whole-body and tissue-specific parameters are fragmentary, controversial, and biased, with most studies using …

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Clinical and mechanistic implication of aspartyl-tRNA synthetase (DARS1) in the transition from MASLD to hepatocellular carcinoma

Natalia Hermán‐Sánchez, Maite G. Fernández‐Barrena, Iker Uriarte, Matias Antonio Avila et autres

SMG7 as a potential contributor to the progression of chronic liver disease to hepatocellular carcinoma

Betsaida Ojeda-Perez, Victor J. Fernandez-Ramirez, José Córdoba‐Chacón, Manuel Rodríguez‐Perálvarez et autres