Junyan Jin

CD26+CD39−CD73+CD4+ T lymphocytes decrease after HIV-1 infection but show an intrinsic association with low viral replication and high CD4+ T-cell count

Xi Zhang, Junyan Jin, Qianqian Xu, Aiwei Zhu et autres

To the Editor: Cluster of differentiation 39 (CD39) is an extracellular ATPase that cleaves adenosine triphosphate (ATP) to adenosine diphosphate and adenosine monophosphate. By doing so, it depletes extracellular ATP that has been generated by the activated T cells or released by …

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Immune profile and mitochondrial alterations driven by age and HIV infection: Associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy

Junyan Jin, Xi Zhang, Qianqian Xu, Wei Xia et autres

ABSTRACT Antiretroviral therapy (ART) has significantly extended the life expectancy of people with HIV (PWH), rendering population ageing and immunosenescence prominent clinical priorities. T-cell senescence is linked to mitochondrial dysfunction and drives age-related immune remodelling, yet how HIV infection and ageing jointly …

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Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (Carassius gibelio, CAS V)

Yu Wang, Yan X Zhang, Liyun Wu, Chaoyue Li et autres

As a precursor to creatine, guanidinoacetic acid (GAA) is widely recognized to enhance growth performance and flesh quality of animals, but the underlying molecular mechanism remains unclear. This study evaluated the effects of dietary GAA supplementation on growth performance, textural properties, and …

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26-A-10359-ACC ANGIOGRAPHY-DERIVED FRACTIONAL FLOW RESERVE VERSUS INTRAVASCULAR ULTRASOUND TO GUIDE PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH OR WITHOUT CHRONIC KIDNEY DISEASE: A POST HOC ANALYSIS OF THE RANDOMIZED FLAVOUR II TRIAL

Jun Jiang, Junyan Jin, Delong Chen, Yuxuan Zhang et autres

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The expression of CD39 on NK cells relates to poor HIV-1 suppression in treatment-naïve HIV-1-infected individuals: Association with elevated IL-10 secretion and TIGIT co-expression

Xin Zhang, Qianqian Xu, Junyan Jin, Hongxia Yan et autres

CD39 exerts an inhibitory effect on tumour progression by impairing the cytotoxic capacity of natural killer (NK) cells against cancer cells. However, the impact of CD39 expression on the non-cytolytic functions of NK cells in treatment-naïve human immunodeficiency virus type 1 (HIV-1)-infected …

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Influences of fishmeal substitution with protein blends on growth performance, protein digestibility, intestinal health, and gut microbiota of gibel carp (Carassius gibelio var. CAS Ⅴ) under thermal stress

Yongning Yu, Zhuocheng Lou, Dong Han, Xiaoming Zhu et autres

Temperature is a crucial environmental factor for poikilothermic aquatic species and can affect their protein utilization. This study examined the impacts of temperature (optimal 27 °C vs. high 33 °C) and protein blends (formulated at 1:1:8:2, 1:1:6:4, and 1:1:4:6 ratios using Chlorella …

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Exercise recovers the decrease in nutritional value, sensory qualities, and antioxidant capacity in muscle induced by a high-fat diet in channel catfish (Ictalurus punctatus)

Xiaomin Hu, 董波, Yu Wang, Zheng Chen et autres

High-fat diets have been widely used in aquaculture because of their protein-sparing effect. However, high-fat diets have some negative effects on flesh quality in farmed fishes. This study investigated the potential of exercise to ameliorate the negative effects of a high-fat diet …

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Left Atrial Appendage Closure in Patients with Atrial Fibrillation and Intermediate-to-Borderline High Cardiovascular Risk: A Retrospective Propensity Match Cohort Study

Jiayi Liu, Ningjing Qian, Ying Gao, Junyan Jin et autres

Background and objective: Evidence of percutaneous left atrial appendage closure (LAAC) and oral anticoagulants (OACs) in non-valvular atrial fibrillation (NVAF) patients with intermediate-to-borderline high stroke risk is scarce. We aimed to compare the efficacy and safety of these treatments in the latter …

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Comparative effects of dietary lutein and zeaxanthin on skin pigmentation, hepatic lipid metabolism, and hypoxia-induced oxidative stress in yellow catfish (Pelteobagrus fulvidraco)

Cui Liu, Haokun Liu, Yue Zheng, Xiaoming Zhu et autres

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USP13 ameliorates myocardial infarction injury by inhibiting ferroptosis via stabilizing ALDOA

Pengcheng Li, Delong Chen, Chenyun Zhang, Qinyan Gong et autres

Despite the central role of deubiquitinases (DUBs) in maintaining protein homeostasis, their important role in post-myocardial infarction (MI) remodeling remains incompletely characterized. Our study identifies a DUB, ubiquitin-specific protease 13 (USP13), as a stress-responsive regulator exhibiting significant downregulation in MI-induced cardiac injury. …

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HIV infection and immunosenescence: challenges and intervention strategies

Junyan Jin, Qianqian Xu, Xin Zhang, Aiwei Zhu et autres

BACKGROUND: Antiretroviral therapy has extended the life expectancy of people with HIV (PWH), leading to a rapidly expanding ageing population of PWH worldwide, including in low- and middle-income countries. The interaction between ageing and chronic HIV infection is closely associated with immunosenescence, …

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Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine

Xiuwen Wang, Xiaodong Yang, Xin Zhang, Hongxia Yan et autres

Objective Both B-cell- and T-cell-mediated immunity are crucial for the effective clearance of viral infection, but little is known about the dynamic characteristics of SARS-CoV-2-specific B-cell and T-cell responses in people living with HIV (PLWH) after a full course of inactivated SARS-CoV-2 …

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