Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine
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Le résumé fourni par la source
Objective Both B-cell- and T-cell-mediated immunity are crucial for the effective clearance of viral infection, but little is known about the dynamic characteristics of SARS-CoV-2-specific B-cell and T-cell responses in people living with HIV (PLWH) after a full course of inactivated SARS-CoV-2 vaccination. Methods In this study, fifty people living with HIV (PLWH) and thirty healthy controls (HCs) were enrolled to assess B-cell and T-cell responses at the day before the vaccination (T0), two weeks after the first dose (T1), two months after the first dose (T2), the day of the third dose (T3), one month after the third dose (T4), three months after the third dose (T5) and 12 months (T6) after the third dose. Results SARS-CoV-2-specific B-cell and T-cell responses were induced in people living with HIV (PLWH), and these responses lasted at least one year after the third vaccine dose. However, the peak frequencies of Spike-specific B-cell and T-cell responses in PLWH were lower than those in HIV-negative controls. In addition, the expansion of activated B cells, memory B cells and plasma cells after primary vaccination was observed, but the percentages of these cells were decreased at T6 and were comparable to those at T0. Additionally, the percentages of activated T cells, exhausted T cells and SARS-CoV-2-specific T cells with enhanced functional activity were increased following the administration of inactivated SARS-CoV-2 vaccine. In addition, PLWH had lower percentages of plasma cells, RBD-specific B cells, circulating Tfh (cTfh) cells and CD38+ cTfh cells, and the percentages of the latter two types of cells were positively correlated with the titer of neutralizing antibodies, indicating these differences may account for the weaker immune responses induced in PLWH. Conclusion These data suggest that specific B-cell and T-cell responses could be sustained for at least one year after receiving the third vaccination. Our findings emphasize that the weak SARS-CoV-2-specific B-cell and T-cell responses induced in PLWH have implications for clinical decision-making and public health policy for PLWH with respect to SARS-CoV-2 infection.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine
- Date Crossref
- 25/02/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Beijing Key Laboratory for HIV/AIDS Research pays non établi dans la noticeUniversité ou école supérieure
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Zhejiang Provincial People's Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing YouAn Hospital pays non établi dans la noticeÉtablissement de santé
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Hangzhou Medical College Department of Rheumatology and Immunology pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Xi'an Jiaotong University Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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Jilin University pays non établi dans la noticeUniversité ou école supérieure
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Jilin Medical University pays non établi dans la noticeUniversité ou école supérieure
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Sichuan University Department of Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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College of Basic Medical Sciences Department of Pathogeny Biology pays non établi dans la noticeUniversité ou école supérieure
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National Center for AIDS/STD Control and Prevention pays non établi dans la noticeInstitution
Beijing Key Laboratory for HIV/AIDS Research — Capital Medical University, Zhejiang Provincial People's Hospital et Beijing YouAn Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.