Hong Lian

A clinical prediction model for beta cell monogenetic diabetes in Chinese patients with early-onset type 2 diabetes

Siyu Sun, Siqian Gong, Tianhao Ba, Meng Li et autres

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Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion

Yingning Liu, Ping Zhang, Simin Zhang, Ying Gao et autres

Context: Current screening methods for hypercortisolism face limitations in clinical practice. Objective: Our study proposes and validates a novel biomarker, the morning spot urinary cortisol-to-creatinine ratio (UCCR), as a simpler alternative for assessing excess cortisol secretion. Methods: This cross-sectional study was conducted …

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Prevalence and Clinical Characteristics of NEUROD1 ‐ MODY in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review

Tianhao Ba, Qian Ren, Siqian Gong, Meng Li et autres

BACKGROUND: Maturity-onset diabetes of the young resulting from mutations of the NEUROD1 gene (NEUROD1-MODY) is a rare form of diabetes and has not been well studied. We aimed to estimate its prevalence in Chinese patients with early-onset type 2 diabetes mellitus (EOD) …

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Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes

Hong Lian, Qian Ren, Wei Liu, Rui Zhang et autres

BACKGROUND: The prevalence of early-onset type 2 diabetes (EOD) is rapidly increasing. This study intends to screen for early cardiovascular abnormalities in patients newly diagnosed with EOD and evaluate the cardiovascular risk across cluster phenotypes. METHOD: A total of 400 patients ≤ …

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The Diminution of R‐Loops Generated by LncRNA DSP‐AS1 Inhibits DSP Gene Transcription to Impede the Re‐Epithelialization During Diabetic Wound Healing

Chen Yang, Hong Lian, Hengli Luo, Chenlin Song et autres

Re-epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms in the context of diabetic wounds remain elusive. In this study, the role of the mesenchymal-epithelial transition (MET) vis-à-vis the epithelial-mesenchymal transition (EMT) of keratinocytes in diabetic …

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Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes

Siqian Gong, Hong Lian, Yating Li, Xiaoling Cai et autres

BACKGRUOUND: Maturity-onset diabetes of the young (MODY) due to variants of hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in the Chinese population. This study aimed to estimate its prevalence and evaluate the application of a clinical screening method …

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Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes

Hong Lian, Siqian Gong, Meng Li, Xirui Wang et autres

CONTEXT: Maturity-onset diabetes of the young 4 (MODY4) is caused by mutations of PDX1; its prevalence and clinical features are not well known. OBJECTIVE: This study aimed to investigate the prevalence and clinical characteristics of MODY4 in Chinese people clinically diagnosed with …

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Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression

Lifeng Zheng, Ximei Shen, Yun Xie, Hong Lian et autres

Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but the mechanism has not been fully elucidated. To reveal the mechanism by which metformin affects hyperglycaemia-induced osteoporosis, we treat a mouse osteoporosis cell model with metformin and find that osteoblast …

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Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study

Xiaosi Hong, Xiaoyun Zhang, Lili You, Feng Li et autres

OBJECTIVES: Adiponectin is closely related to glucose metabolism and traditional diabetes risk factors (obesity, hypertension and dyslipidaemia). We aimed to explore the association between adiponectin levels and newly diagnosed type 2 diabetes mellitus (T2DM) and pre-diabetes in subgroups classified according to T2DM …

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Galectin-3/adiponectin as a new biological indicator for assessing the risk of type 2 diabetes: a cross-sectional study in a community population

Diaozhu Lin, Xiaosi Hong, Kan Sun, Xiaoyun Zhang et autres

OBJECTIVE: This study aimed to explore the association between the risk of newly diagnosed type 2 diabetes and galectin-3 and adiponectin and to investigate whether their joint action shows a favorable diabetes assessment performance. METHODS: We conducted a community-based study in 135 …

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The Risk Threshold for Hemoglobin A1c Associated With Albuminuria: A Population-Based Study in China

Hong Lian, Hongshi Wu, Jie Ning, Diaozhu Lin et autres

Background: Diabetic kidney disease (DKD) is a kind of common microvascular complication of diabetes. This study aims to explore the possible links between blood sugar level and albuminuria, providing the exact cut point of the "risk threshold" for blood glucose with DKD. …

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Associations of GDF-15 and GDF-15/adiponectin ratio with odds of type 2 diabetes in the Chinese population

Xiaoying Wu, Wenting Xuan, Lili You, Hong Lian et autres

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