Le Pham Tien Trieu

A modified decontamination and storage method for sputum from patients with tuberculosis

Nguyen Le Quang, Do Dang Anh Thu, Le Pham Tien Trieu, Nguyen Hanh et autres

Background Collecting and storing large number of sputum samples with a view to culturing these in the future requires an efficient initial handling method. We devised a modified sputum digestion and decontamination method that maximised storage capacity and Mycobacterium tuberculosis (M.tb) recovery …

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Author response: Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

Srinivasan Vijay, Bao Le Hoai Nguyen, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Isoniazid resistance in Mycobacterium tuberculosis is linked to higher rifampicin tolerance, necessitating evaluation and potential adjustment of treatment regimens to combat emerging multi-drug resistant variants.

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Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Antibiotic tolerance in Mycobacterium tuberculosis reduces bacterial killing, worsens treatment outcomes, and contributes to resistance. We studied rifampicin tolerance in isolates with or without isoniazid resistance (IR). Using a minimum duration of killing assay, we measured rifampicin survival in isoniazid-susceptible (IS, n=119) …

kh, gb, cz, vn, fr, de, us (code pays fourni par la source)

Author response: Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or without pre-existing isoniazid-resistance. We determined the in-vitro rifampicin survival fraction by minimum duration …

us, gb, vn, de (code pays fourni par la source)

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Abstract Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or without pre-existing isoniazid-resistance. We determined the in-vitro rifampicin survival fraction by minimum …

kh, gb, cz, vn, fr, de (code pays fourni par la source)

Targeted sequencing from cerebrospinal fluid for rapid identification of drug-resistant tuberculous meningitis

Trinh Thi Bich Tram, Le Pham Tien Trieu, Le Thanh Hoang Nhat, Do Dang Anh Thu et autres

ABSTRACT Mortality from tuberculous meningitis (TBM) remains around 30%, with most deaths occurring within 2 months of starting treatment. Mortality from drug-resistant strains is higher still, making early detection of drug resistance (DR) essential. Targeted next-generation sequencing (tNGS) produces high read depths, …

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A modified decontamination and storage method for sputum from patients with tuberculosis

Nguyen Le Quang, Do Dang Anh Thu, Le Pham Tien Trieu, Nguyen Hanh et autres

Background: (M.tb) recovery from culture while minimising laboratory workload and risk of contamination. Methods: We collected smear microscopy positive sputum samples from patients with pulmonary tuberculosis (TB). The sputum samples were split and processed using both the standard N-Acetyl-L-cysteine and sodium hydroxide …

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Reviewer #2 (Public Review): Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. There is limited understanding of antibiotic tolerance in clinical isolates of M. tuberculosis. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or …

Reviewer #3 (Public Review): Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. There is limited understanding of antibiotic tolerance in clinical isolates of M. tuberculosis. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or …

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Abstract Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. There is limited understanding of antibiotic tolerance in clinical isolates of M. tuberculosis. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with …

kh, gb, cz, vn, fr, de (code pays fourni par la source)

Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

reduces bacterial killing, worsens treatment outcomes, and contributes to resistance. We studied rifampicin tolerance in isolates with or without isoniazid resistance (IR). Using a minimum duration of killing assay, we measured rifampicin survival in isoniazid-susceptible (IS, n=119) and resistant (IR, n=84) isolates, …

kh, gb, cz, vn, fr, de, us (code pays fourni par la source)

Reviewer #1 (Public Review): Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat et autres

Antibiotic tolerance in Mycobacterium tuberculosis leads to less effective bacterial killing, poor treatment responses and resistant emergence. There is limited understanding of antibiotic tolerance in clinical isolates of M. tuberculosis. Therefore, we investigated the rifampicin tolerance of M. tuberculosis isolates, with or …