Jun Saegusa

Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus

Shintaro Yasui, Keisuke Nishimura, Yukina Tanimoto, Michio Mugitani et autres

Protein-losing enteropathy (PLE) is a rare complication of systemic lupus erythematosus (SLE). A 38-year-old woman with well-controlled SLE developed abdominal pain, lower-extremity edema, anemia, and hypoalbuminemia. The patient was then diagnosed with PLE. Despite treatment with glucocorticoids and cyclophosphamide, persistent hypoalbuminemia was …

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Real-World Comparative Effectiveness of Sarilumab Versus Janus Kinase Inhibitors as Monotherapy in Rheumatoid Arthritis

Yuji Nozaki, Kazuya Kishimoto, Tetsu Itami, Daisuke Tomita et autres

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Mode of action- and cause-specific drug retention of b/tsDMARDs in anti-SS-A antibody-positive rheumatoid arthritis: the ANSWER cohort study

Kazuma Nishisaka, T. Okano, Takumi Imai, Masanori Tsubosaka et autres

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Differential Impact of Six JAK Inhibitors on Myeloid Cell Differentiation and Their T Cell Stimulatory Capacity: An In Vitro Comparative Study

Kazuma Nishisaka, Sho Sendo, Alfonso Del Peral-Fanjul, Mai Yamashita et autres

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Dual inhibition of glutaminolysis and autophagy suppresses proliferation of Rheumatoid arthritis fibroblast-like synoviocytes and mitigates arthritis in SKG mice

I. Naka, Sho Sendo, T. Okano, Kenichi Uto et autres

Abstract Recent evidence highlights the critical role of immune metabolism in the pathogenesis of rheumatoid arthritis (RA). We previously demonstrated that glutaminase 1 (GLS1), a key enzyme in glutamine metabolism, is upregulated in fibroblast-like synoviocytes from RA patients (RA-FLS) and that GLS1 …

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Impact of dysregulated microbiota-derived C18 polyunsaturated fatty acid metabolites on arthritis severity in mice with collagen-induced arthritis

Katsuhiko Yoneda, Sho Sendo, T. Okano, Hidenori Shimizu et autres

Objective We aimed to evaluate microbiome and microbiota-derived C18 dietary polyunsaturated fatty acids (PUFAs), such as conjugated linoleic acid (CLA), and to investigate their differences that correlate with arthritis severity in collagen-induced arthritis (CIA) mice. Methods On day 84 after induction, during …

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Author response for "Zymosan‐Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint"

Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto et autres

Author response for "Zymosan‐Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint"

Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto et autres

Resolvin D5 Modulates Th17/Treg Cell Differentiation and Suppresses Osteoclastogenesis.

Hirotaka Yamada, Jun Saegusa, Sho Sendo, Yo Ueda et autres

Abstract Resolvins, are specialized pro-resolving mediators (SPMs) derived from n-3 polyunsaturated fatty acids. They contribute actively to the resolution of inflammation, but little is known concerning their role in chronic inflammation, such as in rheumatoid arthritis (RA). Here, we performed lipid mediator …

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Comparison of the drug retention and reasons for discontinuation of Tumor Necrosis Factor Inhibitors and Interleukin-6 Inhibitors in patients with Elderly-onset Rheumatoid Arthritis-the ANSWER cohort study

Sadao Jinno, Akira Ōnishi, Maureen Dubreuil, Motomu Hashimoto et autres

Abstract Background: This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of either Tumor Necrosis Factor inhibitors (TNFi) or Interleukin-6 Inhibitors (IL-6i) in patients with elderly-onset rheumatoid arthritis (EORA).Methods: Patients with rheumatoid arthritis (RA) enrolled in a Japanese …

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