Niels‐Christian Reichardt

Novel Lectins from Bauhinia with Differential N- Glycan Binding Profiles

Vinicius José Silva Osterne, Lara Dias Lima, Messias Vital Oliveira, Vanir Reis Pinto‐Junior et autres

High Resolution Image Download MS PowerPoint Slide The specific interaction of lectins with carbohydrates and glycoconjugates grants these proteins a distinct ability to decode the glycocode. Essential for various biological processes in all organisms, this carbohydrate-binding activity also establishes lectins as valuable …

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Author response for "Quantifying Siglec-Sialylated Ligand Interactions: A versatile 19F-T2 CPMG Filtered Competitive NMR Displacement Assay"

Unai Atxabal, Andrea T. Fernandez, María Jesús Moure, Klaudia Sobczak et autres

A Versatile Urea Type Linker for Functionalizing Natural Glycans and Its Validation in Glycan Arrays

Sonia Serna, Raik Artschwager, Damián Pérez‐Martínez, Rosa López et autres

The isolation from organisms and readily available glycoproteins has become an increasingly convenient source of N-glycans for multiple applications including glycan microarrays, as reference standards in glycan analysis or as reagents that improve bioavailability of protein and peptide therapeutics through conjugation. A …

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N-glycans Other Than MUXF3 Are Targets For Specific IgE Antibodies Against Juniperus ashei Pollen Allergens

Javier Álvarez, Tamara Aranda, Rocío Ruiz, Leire Aramendia et autres

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A galactoside-specific Dalbergieae legume lectin from seeds of Vataireopsis araroba (Aguiar) Ducke

Vinicius José Silva Osterne, Messias Vital Oliveira, Kristof De Schutter, Sonia Serna et autres

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N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV–Cell Interaction and Functional Activation of Endothelial Cells

Marta Clos‐Sansalvador, Sergio G. Garcia, Miriam Font‐Morón, C. B. Williams et autres

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EV) are widely considered as a cell-free therapeutic alternative to MSC cell administration, due to their immunomodulatory and regenerative properties. However, the interaction mechanisms between EV and target cells are not fully understood. The surface glycans could …

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Glycosylation reduces the glycan-independent immunomodulatory effect of recombinant Orysata lectin in Drosophila S2 cells

Pengyu Chen, Kristof De Schutter, Sonia Serna, Simin Chen et autres

Several plant lectins, or carbohydrate-binding proteins, interact with glycan moieties on the surface of immune cells, thereby influencing the immune response of these cells. Orysata, a mannose-binding lectin from rice, has been reported to exert immunomodulatory activities on insect cells. While the …

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Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Stefania Robakiewicz, Clarisse Bridot, Sonia Serna, Ana Gimeno et autres

Abstract \n Paucimannosidic glycans are restricted to the core structure [Man1–3GlcNAc2Fuc0–1] of N-glycans and are rarely found in mammalian tissues. Yet, especially [Man2-3GlcNAc2Fuc1] have been found significantly upregulated in tumors, including in colorectal and liver cancer. Mannitou IgM is a murine monoclonal …

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Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series

Jasmin Heidepriem, Christine Dahlke, Robin Kobbe, René Santer et autres

The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A better understanding of its immunogenicity can be important for the development of improved diagnostics, therapeutics, and vaccines. Here, we report the longitudinal analysis of three COVID-19 patients …

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Chemo‐Enzymatic Synthesis of S. mansoni O‐Glycans and Their Evaluation as Ligands for C‐Type Lectin Receptors MGL, DC‐SIGN, and DC‐SIGNR

Julie Pham, Alvaro Gonzalo Hernandez, Anna Cioce, Silvia Achilli et autres

Due to their interactions with C-type lectin receptors (CLRs), glycans from the helminth Schistosoma mansoni represent promising leads for treatment of autoimmune diseases, allergies or cancer. We chemo-enzymatically synthesized nine O-glycans based on the two predominant O-glycan cores observed in the infectious …

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The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

José Daniel Martínez, Angela Simona Infantino, Pablo Valverde, Tammo Diercks et autres

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein–glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein–ligand complexes. We herein present a new methodology …

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TETRALEC, Artificial Tetrameric Lectins: A Tool to Screen Ligand and Pathogen Interactions

Silvia Achilli, João T. Monteiro, Sonia Serna, Sabine Mayer-Lambertz et autres

C-type lectin receptor (CLR)/carbohydrate recognition occurs through low affinity interactions. Nature compensates that weakness by multivalent display of the lectin carbohydrate recognition domain (CRD) at the cell surface. Mimicking these low affinity interactions in vitro is essential to better understand CLR/glycan interactions. …

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