Conrado Aparicio

Mesoporous strontium silicates nanostructures as potential bone regeneration tool: an engineering approach to tune shape/structure- Data Sharing Archive [Dataset]

Dhiraj Kumar, Taruna Singh, Tristen Nies, Grace Liu et autres

Mesoporous silicates nanoparticles are known to find application in various fields ranging from medicine to devices. In addition, with the incorporation of metal within the silicate domain, the nanoparticles have advanced the tissue engineering field by tailoring the cellular function with for …

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Biological and microbiological properties of low-modulus Ti-35Nb-4Ag alloy obtained by powder metallurgy for dental implant applications

Matilde Roquette, Javier Gil, Conrado Aparicio, Nicolás Padrós et autres

Objective Stress shielding and bacterial infection are among the main challenges associated with metallic implants. To address these limitations, a Ti-35Nb-4Ag alloy was produced by powder metallurgy, combining a low elastic modulus (67.9 ± 1.1 GPa) with silver incorporated in solid solution …

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Enhanced piezoelectric collagen with aligned microstructure for synergistic electro-topological skeletal muscle regeneration

Jiaxin Hao, Gao‐peng Dang, Yingbo Ji, Yuzhu Wang et autres

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Effect of Plastic Deformation-Induced Residual Stress on the Corrosion Behavior of Monoblock Dental Implants: Implications for Clinical Performance

Alejandra Partida, Marco A. L. Hernandez-Rodriguez, Meritxell Molmeneu, Miquel Punset et autres

Background/Objectives: One-piece (monoblock) dental implants are increasingly used, particularly in patients with limited bone availability. Prosthetic alignment is often achieved via plastic deformation of the titanium implant. This study aimed to evaluate the impact of such deformation-induced residual stress on the corrosion …

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Biomimetic mineralization of electrospun elastin-like recombinamer nanofibers

Caixia Lan, Daniel Moreno, JC Rodriguez-Cabello, Lina Niu et autres

One of the key factors for hard tissue regeneration is to develop mineralized fibrous scaffolds. These scaffolds can provide a micro-environment resembling the structure and mechanical properties of the extracellular matrix (ECM) of hard tissues favorable for subsequent cell responses and tissue …

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Bone adhesive with temporally-synchronized degradation for enhanced osteointegration

Jun-ting Gu, Zhi-ting Li, Yuzhu Wang, Dongxiao Hao et autres

Bone adhesives have emerged as promising alternatives for complex fracture fixation. However, discrepancies between material degradation rates and the physiological timeline of bone healing remain a critical limitation. Here, a polyurethane-based adhesive (TNC) was developed, synthesized from trimeric hexamethylene diisocyanate, nano-hydroxyapatite, and …

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Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis

Weiwei Yu, Kai Jiao, Kaiyan Wang, Xiang Li et autres

Ionizing radiation is effective in treating cancer but causes significant damage to the mucosa, thereby increasing patient discomfort, delaying therapy, and raising the risk of mortality. The underlying mechanisms of this damage remain poorly understood, and current treatments are largely palliative. In …

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Ferric tannate-functionalized hierarchical porous materials for hemostatic antibacterial non-compressible bleeding

Longzhang Niu, Jinghan Song, Haoran Xu, Wei Yu et autres

An injectable water-responsive hierarchical porous shape-memory material was prepared, featuring ultrahigh blood absorption (>4600%), ultrafast shape recovery (∼6 s), robust antibacterial activity (>99.9%), and coagulation-independent hemostasis.

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Perspective opportunities and challenges in translating dental materials into clinical practice

Yi Ma, Ye Tao, Ling Li, Yongsheng Zhou et autres

The clinical translation of dental materials presents significant opportunities, driven by increasing market demand, supportive regulatory frameworks, and advancements in digital and additive manufacturing technologies. These factors facilitate enhanced personalization, improved biocompatibility, and superior aesthetic and mechanical properties of dental products. However, …

Hydrogen bonding enforced supramolecular multifunctional nanocoating for implant osseointegration

Junhong Qiu, Qianqian Qiu, Jiawei Yang, Weilong Tang et autres

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Polarity of hemidesmosome instructive light-curable biosealants guides nascent extracellular matrix for favorable epithelial interactions

Nicholas G. Fischer, David A. De Jong, Michael D. Evans, Conrado Aparicio

Percutaneous medical devices - such as prosthetic limbs, dental implants, and subgingival dental restorations - commonly fail due to their susceptibility to infection, posing serious morbidity and mortality and a significant economic burden. Current solutions for subgingival dental restoration failure - such …

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Magnesium‐Doped Coatings as a Suitable Approach to Improve Osseointegration of Titanium‐Based Implants: A Systematic Review and Meta‐Analyses of Animal Studies

Cícero Andrade Sigilião Celles, Conrado Aparicio, Valentim Adelino Ricardo Barão, Caroline Dini

ABSTRACT This review evaluates the effect of magnesium (Mg)‐doped coatings on the osseointegration of titanium (Ti)‐based implants. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses and the PRISMA 2020 Statement were followed, with registration in PROSPERO (CRD42024572571). The …

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