Marta Biesiekierska

OXCT1 knockout suppresses HeLa cell proliferation and invasiveness through adhesion proteins and the PI3K/Akt-Snail pathway

Kamila Soboska, Maciej Studzian, Marta Biesiekierska, Luciano Pirola et autres

While the OXCT1 gene (3-oxoacid CoA-transferase 1, and its gene product SCOT; succinyl-CoA:3-ketoacid CoA transferase) is primarily recognised as the rate-limiting enzyme in ketone body catabolism, accumulating evidence indicates that ketone bodies and ketogenic diets exert complex, context-dependent effects on cancer progression. …

pl, fr (code pays fourni par la source)

Contributors

Seán T. Anderson, Olivia S. Anderson, Aneta Balcerczyk, Aarya Bavare et autres

The Impact of Ketogenic Nutrition on Obesity and Metabolic Health: Mechanisms and Clinical Implications

Marta Biesiekierska, Maura Strigini, Agnieszka Śliwińska, Luciano Pirola et autres

The ketogenic diet (KD) has recently gained increasing popularity. This high-fat, adequate-protein, and carbohydrate-poor eating pattern leads to nutritional ketosis. The KD has long been known for its antidiabetic and antiepileptic effects and has been used therapeutically in these contexts. Recently, the …

pl, fr (code pays fourni par la source)

Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing

Melania Maria Serafini, Sara Sepehri, Miriam Midali, Marth Stinckens et autres

Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and underlying mechanisms of toxicants on the human nervous system. In recent years, there has been an increasing focus on the so-called new approach methodologies (NAMs). The Organization …

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LP-33: A urothelial cell model for the new therapeutics efficacy assessment

Marta Biesiekierska, Edyta Wieczorek, Anna Wolniakowska, K. Mierczak et autres

pl (code pays fourni par la source)

Analysis of the possibility of using ketone bodies and transferase succinyl-CoA:3-ketoacid-CoA as potential tools in the treatment of cervical cancer in vitro

Marta Biesiekierska

Prowadzenie intensywnych badań nad nowotworami prowadzi do stworzenia nowych podejść terapeutycznych, a także modyfikacji już istniejących, głównie w celu zredukowania występujących efektów ubocznych. Coraz częściej podkreśla się także rolę diety jako istotnego czynnika wspomagającego leczenie pacjenta. Badania metabolizmu komórek nowotworowych wykazały zwiększone …

Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives

Oskar Ciesielski, Marta Biesiekierska, Baptiste Panthu, Mirosław Soszyński et autres

Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell through altering the structure and functions of proteins. The action of the most prevalent PTMs, encompassing phosphorylation, methylation, acylations, ubiquitination and glycosylation is well documented. A less explored protein PTM, conversion …

pl, fr (code pays fourni par la source)

Impact of Long-Term Manure and Sewage Sludge Application to Soil as Organic Fertilizer on the Incidence of Pathogenic Microorganisms and Antibiotic Resistance Genes

Hana Stiborová, Martina Kracmarova, Tereza Vesela, Marta Biesiekierska et autres

The reuse of stabilized (under thermophilic conditions) sewage sludge and manure on agricultural soils is a common practice. The aim of this study was to evaluate the risks associated with their repeated applications on the spread of pathogenic bacteria and antibiotic resistance …

cz (code pays fourni par la source)

Modulation of noncoding RNAs (ncRNAs) and their potential role as therapeutics

Luciano Pirola, Oskar Ciesielski, Marta Biesiekierska, Aneta Balcerczyk

Besides the classical view of RNA as an intermediate carrier of genetic information from the DNA, the protein via the template function of messenger RNA (mRNA), a larger and much more heterogeneous group of noncoding RNAs (ncRNAs) contributes to the regulation of …

fr, pl (code pays fourni par la source)

Contributors

Charbel Abi Khalil, Robert E. Akins, T. Alenghat, Emily Graves Allen et autres

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Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters

Souad Nasser, Varvara Vialichka, Marta Biesiekierska, Aneta Balcerczyk et autres

Ketone bodies have emerged as central mediators of metabolic health, and multiple beneficial effects of a ketogenic diet, impacting metabolism, neuronal pathologies and, to a certain extent, tumorigenesis, have been reported both in animal models and clinical research. Ketone bodies, endogenously produced …

fr, pl (code pays fourni par la source)

Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells

Oskar Ciesielski, Marta Biesiekierska, Aneta Balcerczyk

Epigallocatechin gallate (EGCG), the main green tea polyphenol, exerts a wide variety of biological actions. Epigenetically, the catechin has been classified as a DNMTs inhibitor, however, its impact on histone modifications and chromatin structure is still poorly understood. The purpose of this …

pl (code pays fourni par la source)