Sing Yian Chew

Ion-shielding ultrathin encapsulation with hot-press bonded interface enables chronic stretchable bioelectronics

Zhi Jiang, Guijin Zou, Wei Ju, Jing Yu et autres

Stretchable physiological electrodes are indispensable for continuous, high-fidelity bio-signal monitoring, yet liquid water and ions invade nano/microscopic interfacial defects and silence signals within weeks. We introduce an ion-shielding ultrathin encapsulation that is molecularly fused to the stretchable conductor with a hot-press bonded …

sg, cn (code pays fourni par la source)

Voices across time and around the world: Honoring Dr. Kam Leong’s legacy

Hai-Quan Mao, Chai-Hoon Quek, Yeh-Hsing Lao, Shu Chien et autres

3D-printed scaffolds encapsulating red-blood-cell-derived extracellular vesicles for microRNA delivery

Chongquan Huang, Migara Kavishka Jayasinghe, Vaibavi Ramanujam, Kieran Lau et autres

Small non-coding RNAs (sncRNAs) hold strong therapeutic potential, but clinical translation is limited by the cytotoxicity and poor efficiency of conventional delivery vectors. Red-blood-cell-derived extracellular vesicles (RBCEVs) provide a biocompatible alternative, yet their application in the central nervous system (CNS) remains underexplored. …

sg, au (code pays fourni par la source)

Nanoplex cluster-mediated synergistic modulation of dendritic cells and T cells amplifies tumor-specific adaptive immunity

Wei Mao, Yeonju Park, Song Rae Kim, Sing Yian Chew et autres

kr, sg (code pays fourni par la source)

Microchannel-containing hydrogel scaffolds enabled functional recovery in the absence of cells and bioactive molecules following spinal cord injury

Vaibavi Srirangam Ramanujam, Kieran Lau, Chongquan Huang, Christy Kwokdinata et autres

assessments using a rat spinal cord complete transection model showed that, in the absence of cells or bioactive molecules, the microchannel-containing scaffolds enabled neurite ingrowth and promoted functional recovery of the hindlimbs over the 3-month implantation period. While the formation of cystic …

sg, au, fr (code pays fourni par la source)

Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces

Ernest Cheah, Xinchao Gao, Wei Qi Jaw, Guo Liang Goh et autres

Abstract Organotypic 3D tissue models require precise electrophysiological interfaces to study function and disease. Multi‐electrode arrays (MEAs) are essential for recording and stimulation, yet conventional fabrication methods are costly and time‐intensive. This study demonstrates aerosol jet printing (AJP) of gold nanoparticles onto …

sg (code pays fourni par la source)

3D-Printed Scaffolds Encapsulating Red Blood Cell Extracellular Vesicles for MicroRNA Delivery

Chongquan Huang, Migara Kavishka Jayasinghe, Vaibavi Ramanujam, Kieran Lau et autres

Abstract Small non-coding RNAs (sncRNA) hold promising therapeutic potential. However, their clinical application is hindered by the poor cytocompatibility and limited transfection efficiency of conventional delivery vectors. In contrast, red blood cell-derived extracellular vesicles (RBCEVs) offer a safer, more efficient, and cost-effective …

sg, au (code pays fourni par la source)

Sustained MicroRNA delivery enhanced remyelination and functional recovery after spinal cord injury

Chongquan Huang, Ruby Singh, Nareekarn Chueakula, Sing Yian Chew

sg (code pays fourni par la source)

Bioprinted Microchannel Scaffolds Modulate Neuronal Differentiation of Encapsulated Human Spinal Cord Progenitor Cells

Christy Kwokdinata, Kieran Lau, Jerome Zu Yao Tan, Sing Yian Chew

A potential approach for treating spinal cord injuries is the implantation of human induced pluripotent stem cells-derived spinal cord progenitor cells (SCPCs) encapsulated in hydrogels. Digital light processing (DLP) enables the fabrication of scaffolds with high microchannel packing density, which are essential …

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Breathing Laser-Spectral Mapping of Cavity-Enhanced Redox Reactions with Subcellular Resolution

Hui Zhu, Guocheng Fang, Ningyuan Nie, Jun Xie et autres

Precise and dynamic observation of redox reactions in living organisms holds significant importance for the study of physiological processes and pathological mechanisms. However, the current technologies still make it challenging to monitor this process in a nondestructive and highly sensitive manner. Herein, …

cn, sg (code pays fourni par la source)

Additive manufacturing in spatial patterning for spinal cord injury treatment

Christy Kwokdinata, Sing Yian Chew

sg (code pays fourni par la source)

Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells

Jerome Zu Yao Tan, Jiahui Chen, Daniel Ninio Roxby, Wai Hon Chooi et autres

The emergence of induced pluripotent stem cells (iPSCs) offers a promising approach for replacing damaged neurons and glial cells, particularly in spinal cord injuries (SCI). Despite its merits, iPSC differentiation into spinal cord progenitor cells (SCPCs) is variable, necessitating reliable assessment of …

sg, us (code pays fourni par la source)