Chongquan Huang

Metabolic-epigenetic regulation of TRPM3 via H3K18 lactylation in dorsal root ganglia mediates bone cancer pain and its attenuation by microwave ablation

Tiantian Wei, Guoqing Zhong, Jin Gui Qian, Jinfeng Wang et autres

cn (code pays fourni par la source)

3D-printed scaffolds encapsulating red-blood-cell-derived extracellular vesicles for microRNA delivery

Chongquan Huang, Migara Kavishka Jayasinghe, Vaibavi Ramanujam, Kieran Lau et autres

Small non-coding RNAs (sncRNAs) hold strong therapeutic potential, but clinical translation is limited by the cytotoxicity and poor efficiency of conventional delivery vectors. Red-blood-cell-derived extracellular vesicles (RBCEVs) provide a biocompatible alternative, yet their application in the central nervous system (CNS) remains underexplored. …

sg, au (code pays fourni par la source)

Integrated scaffold structure, mechanical cues, and rbcev-based delivery for neural repair after spinal cord injury

Chongquan Huang

Spinal cord injury remains a major clinical challenge due to the limited regenerative capacity of the adult central nervous system and the complex, multi-factorial nature of the post-injury microenvironment. Following injury, disrupted tissue architecture, altered mechanical properties, inhibitory extracellular matrix deposition, and …

Microchannel-containing hydrogel scaffolds enabled functional recovery in the absence of cells and bioactive molecules following spinal cord injury

Vaibavi Srirangam Ramanujam, Kieran Lau, Chongquan Huang, Christy Kwokdinata et autres

assessments using a rat spinal cord complete transection model showed that, in the absence of cells or bioactive molecules, the microchannel-containing scaffolds enabled neurite ingrowth and promoted functional recovery of the hindlimbs over the 3-month implantation period. While the formation of cystic …

sg, au, fr (code pays fourni par la source)

Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces

Ernest Cheah, Xinchao Gao, Wei Qi Jaw, Guo Liang Goh et autres

Abstract Organotypic 3D tissue models require precise electrophysiological interfaces to study function and disease. Multi‐electrode arrays (MEAs) are essential for recording and stimulation, yet conventional fabrication methods are costly and time‐intensive. This study demonstrates aerosol jet printing (AJP) of gold nanoparticles onto …

sg (code pays fourni par la source)

3D-Printed Scaffolds Encapsulating Red Blood Cell Extracellular Vesicles for MicroRNA Delivery

Chongquan Huang, Migara Kavishka Jayasinghe, Vaibavi Ramanujam, Kieran Lau et autres

Abstract Small non-coding RNAs (sncRNA) hold promising therapeutic potential. However, their clinical application is hindered by the poor cytocompatibility and limited transfection efficiency of conventional delivery vectors. In contrast, red blood cell-derived extracellular vesicles (RBCEVs) offer a safer, more efficient, and cost-effective …

sg, au (code pays fourni par la source)

Sustained MicroRNA delivery enhanced remyelination and functional recovery after spinal cord injury

Chongquan Huang, Ruby Singh, Nareekarn Chueakula, Sing Yian Chew

sg (code pays fourni par la source)

Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration

Wenjie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao et autres

Sterile alpha and Toll/interleukin-1 receptor motif containing 1 (SARM1), a nicotinamide adenine dinucleotide (NAD)-utilizing enzyme, mediates axon degeneration (AxD) in various neurodegenerative diseases. It is activated by nicotinamide mononucleotide (NMN) to produce a calcium messenger, cyclic ADP-ribose (cADPR). This activity is blocked …

cn (code pays fourni par la source)

Gap Junction Intercellular Communications Regulates Activation of SARM1 and Protects Against Axonal Degeneration

Yong Juan Zhao, Wenjie Zhu, Jun Liu, Wan Hua Li et autres

hk, cn (code pays fourni par la source)

Nontoxic, Biodegradable Hyperbranched Poly(β-amino ester)s for Efficient siRNA Delivery and Gene Silencing

Ying Jie Ooi, Chongquan Huang, Kieran Lau, Sing Yian Chew et autres

RNA interference (RNAi)-mediated gene silencing is a promising therapeutic approach to treat various diseases, but safe and efficient delivery remains a major challenge to its clinical application. Non-viral gene vectors, such as poly(β-amino esters) (pBAEs), have emerged as a potential candidate due …

sg, ch (code pays fourni par la source)

Neural cell membrane-coated DNA nanogels as a potential target-specific drug delivery tool for the central nervous system

Po Hen Lin, Chongquan Huang, Yuwei Hu, Vaibavi Srirangam Ramanujam et autres

sg (code pays fourni par la source)

Mechanical Stretch Promotes Neurite Outgrowth of Primary Cultured Dorsal Root Ganglion Neurons via Suppression of Semaphorin 3A-Neuropilin-1/Plexin-A1 Signaling

Meili Liu, Zitong An, Yu Zhang, Yuchen Xiao et autres

Significant attempts have been made to promote neuronal extension and migration in nerve development and regeneration. Although mechanical stretch induces persistent elongation of the axon, the underlying molecular mechanisms are not yet clear. Some axonal guidance cues secreted in the growth cone …

cn (code pays fourni par la source)